{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:45:29Z","timestamp":1790390729559,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In recent decades, hormonal contraceptives (HC) has made a difference in the control of female fertility, taking an unequivocal role in improving contraceptive efficacy. Some side effects of hormonal treatments have been carefully studied. However, the influence of these drugs on female sexual functioning is not so clear, although variations in the plasma levels of sexual hormones could be associated with sexual dysfunction. Permanent hormonal modifications, during menopause or caused by some endocrine pathologies, could be directly related to sexual dysfunction in some cases but not in all of them. HC use seems to be responsible for a decrease of circulating androgen, estradiol, and progesterone levels, as well as for the inhibition of oxytocin functioning. Hormonal contraceptive use could alter women\u2019s pair-bonding behavior, reduce neural response to the expectation of erotic stimuli, and increase sexual jealousy. There are contradictory results from different studies regarding the association between sexual dysfunction and hormonal contraceptives, so it could be firmly said that additional research is needed. When contraceptive-related female sexual dysfunction is suspected, the recommended therapy is the discontinuation of contraceptives with consideration of an alternative method, such as levonorgestrel-releasing intrauterine systems, copper intrauterine contraceptives, etonogestrel implants, the permanent sterilization of either partner (when future fertility is not desired), or a contraceptive ring.<\/jats:p>","DOI":"10.3390\/jcm8060908","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T10:52:31Z","timestamp":1561459951000},"page":"908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Hormonal Contraceptives, Female Sexual Dysfunction, and Managing Strategies: A Review"],"prefix":"10.3390","volume":"8","author":[{"given":"Nerea M.","family":"Casado-Espada","sequence":"first","affiliation":[{"name":"Psychiatry Service, Institute of Biomedical Research of Salamanca (IBSAL), University Clinical Hospital of Salamanca, Paseo San Vicente, SN 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"de Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Institute of Biomedical Research of Salamanca (IBSAL), University Clinical Hospital of Salamanca, Paseo San Vicente, SN 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier I.","family":"de la Iglesia-Larrad","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Institute of Biomedical Research of Salamanca (IBSAL), University Clinical Hospital of Salamanca, Paseo San Vicente, SN 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Bote-Bonaechea","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Institute of Biomedical Research of Salamanca (IBSAL), University Clinical Hospital of Salamanca, Paseo San Vicente, SN 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-1333","authenticated-orcid":false,"given":"\u00c1ngel L.","family":"Montejo","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Institute of Biomedical Research of Salamanca (IBSAL), University Clinical Hospital of Salamanca, Paseo San Vicente, SN 37007 Salamanca, Spain"},{"name":"Nursing School E.U.E.F., University of Salamanca, Av. 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J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Egarter, C., Frey Tirri, B., Bitzer, J., Kaminskyy, V., Oddens, B.J., Prilepskaya, V., Yeshaya, A., Marintcheva-Petrova, M., and Weyers, S. (2013). Women\u2019s perceptions and reasons for choosing the pill, patch, or ring in the CHOICE study: A cross-sectional survey of contraceptive method selection after counseling. BMC Womens. Health, 13.","DOI":"10.1186\/1472-6874-13-9"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/humupd\/dmp020","article-title":"Female contraception over 40","volume":"15","author":"Baird","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/AOG.0000000000001286","article-title":"Sexual Desire and Hormonal Contraception","volume":"127","author":"Boozalis","year":"2016","journal-title":"Obstet. Gynecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.3109\/13625187.2010.533002","article-title":"Contraceptive use and behavior in the 21st century: a comprehensive study across five European countries","volume":"15","author":"Skouby","year":"2010","journal-title":"Eur. J. Contracept. Reprod. Heal. Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.3109\/13625187.2011.607690","article-title":"The Reproductive Health Report: The state of sexual and reproductive health within the European Union","volume":"16","author":"Albrecht","year":"2011","journal-title":"Eur. J. Contracept. Reprod. Heal. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.contraception.2012.05.017","article-title":"Types of combined oral contraceptives used by US women","volume":"86","author":"Hall","year":"2012","journal-title":"Contraception"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jogc.2016.10.005","article-title":"No. 329-Canadian Contraception Consensus Part 4 of 4 Chapter 9: Combined Hormonal Contraception","volume":"39","author":"Black","year":"2017","journal-title":"J. Obstet. Gynaecol. Canada"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/1570161115666170609101502","article-title":"Sexual Dysfunction, Cardiovascular Risk and Effects of Pharmacotherapy","volume":"16","author":"Imprialos","year":"2018","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/YCO.0000000000000198","article-title":"Sexual side-effects of antidepressant and antipsychotic drugs","volume":"28","author":"Montejo","year":"2015","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/wps.20509","article-title":"The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management","volume":"17","author":"Montejo","year":"2018","journal-title":"World Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1111\/j.1743-6109.2010.01709.x","article-title":"Frequency of sexual dysfunction in patients with a psychotic disorder receiving antipsychotics","volume":"7","author":"Montejo","year":"2010","journal-title":"J. Sex. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s10508-018-1365-6","article-title":"A Real-World Study on Antidepressant-Associated Sexual Dysfunction in 2144 Outpatients: The SALSEX I Study","volume":"48","author":"Montejo","year":"2019","journal-title":"Arch. Sex. Behav."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40618-016-0542-5","article-title":"Sexual function in young women with type 1 diabetes: the METRO study","volume":"40","author":"Maiorino","year":"2017","journal-title":"J. Endocrinol. Invest."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ijir.3901333","article-title":"Obesity, the metabolic syndrome, and sexual dysfunction","volume":"17","author":"Esposito","year":"2005","journal-title":"Int. J. Impot. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.maturitas.2016.02.009","article-title":"A biopsychosocial approach to women\u2019s sexual function and dysfunction at midlife: A narrative review","volume":"87","author":"Thomas","year":"2016","journal-title":"Maturitas"},{"key":"ref_19","first-page":"123","article-title":"Management of postpartum loss of libido","volume":"18","author":"Hughes","year":"2008","journal-title":"J. Fam. Health Care"},{"key":"ref_20","unstructured":"(2019, January 05). FDA Office of Women\u2019s Health Birth Control Guide, Available online: https:\/\/www.fda.gov\/media\/99605\/download."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jogc.2015.12.003","article-title":"Canadian Contraception Consensus (Part 3 of 4): Chapter 8-Progestin-Only Contraception","volume":"38","author":"Black","year":"2016","journal-title":"J. Obstet. Gynaecol. Canada"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jogc.2015.12.002","article-title":"Canadian Contraception Consensus (Part 3 of 4): Chapter 7-Intrauterine Contraception","volume":"38","author":"Black","year":"2016","journal-title":"J. Obstet. Gynaecol. Canada"},{"key":"ref_23","unstructured":"World Health Organization (2018). Recomendaciones sobre pr\u00e1cticas seleccionadas para el uso de anticonceptivos, World Health Organization."},{"key":"ref_24","unstructured":"S\u00e1nchez Borrego, R., and Mart\u00ednez P\u00e9rez, \u00d3. (2003). Gu\u00eda pr\u00e1ctica de anticoncepci\u00f3n oral basada en la evidencia, Emisa."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.yhbeh.2013.02.013","article-title":"Hormonal predictors of sexual motivation in natural menstrual cycles","volume":"63","author":"Roney","year":"2013","journal-title":"Horm. Behav."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.evolhumbehav.2016.10.006","article-title":"Estrogenic and progestogenic effects of hormonal contraceptives in relation to sexual behavior: insights into extended sexuality","volume":"38","author":"Grebe","year":"2017","journal-title":"Evol. Hum. Behav."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1177\/0956797613485965","article-title":"Women\u2019s luteal-phase sexual proceptivity and the functions of extended sexuality","volume":"24","author":"Grebe","year":"2013","journal-title":"Psychol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2165\/00003495-200363050-00003","article-title":"Progestogens with antiandrogenic properties","volume":"63","author":"Raudrant","year":"2003","journal-title":"Drugs"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2298\/MPNS0310446B","article-title":"Hormones and female sexuality","volume":"56","author":"Bjelica","year":"2003","journal-title":"Med. Pregl."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/humupd\/dmi046","article-title":"New progestagens for contraceptive use","volume":"12","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1016\/j.jsxm.2017.10.017","article-title":"O-08 Alteration of the Sexual Response Cycle in Women Using Combined Oral Contraceptives","volume":"14","year":"2017","journal-title":"J. Sex. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2147\/IJWH.S46811","article-title":"New and emerging contraceptives: a state-of-the-art review","volume":"6","author":"Bahamondes","year":"2014","journal-title":"Int. J. Womens. Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0015-0282(02)03001-7","article-title":"Hormones, mood, sexuality, and the menopausal transition","volume":"77","author":"Dennerstein","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3109\/09513590.2013.830100","article-title":"Counseling on vaginal delivery of contraceptive hormones: Implications for women\u2019s body knowledge and sexual health","volume":"29","author":"Benedetto","year":"2013","journal-title":"Gynecol. Endocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/scan\/nsv157","article-title":"Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner\u2019s face","volume":"11","author":"Scheele","year":"2016","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders: DSM-5, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_37","unstructured":"World Health Organization (2006). Defining Sexual Health: Report of a Technical Consultation on Sexual Health, World Health Organization."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/bmj.327.7412.426","article-title":"Sexual function problems and help seeking behaviour in Britain: national probability sample survey","volume":"327","author":"Mercer","year":"2003","journal-title":"BMJ"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1743-6109.2012.02702.x","article-title":"What we don\u2019t talk about when we don\u2019t talk about sex: results of a national survey of U.S. obstetrician\/gynecologists","volume":"9","author":"Sobecki","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1743-6109.2007.00496.x","article-title":"Women\u2019s Endorsement of Models of Female Sexual Response: The Nurses\u2019 Sexuality Study","volume":"4","author":"Sand","year":"2007","journal-title":"J. Sex. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00926230590475206","article-title":"The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores","volume":"31","author":"Wiegel","year":"2005","journal-title":"J. Sex Marital Ther."},{"key":"ref_42","first-page":"297","article-title":"Oral contraceptives and libido in women","volume":"15","author":"Davis","year":"2004","journal-title":"Annu. Rev. Sex Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/13625187.2012.728643","article-title":"The influence of combined oral contraceptives on female sexual desire: a systematic review","volume":"18","author":"Pastor","year":"2013","journal-title":"Eur. J. Contracept. Reprod. Health Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.psyneuen.2006.12.011","article-title":"Does oral contraceptive-induced reduction in free testosterone adversely affect the sexuality or mood of women?","volume":"32","author":"Graham","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.contraception.2010.02.016","article-title":"Effects of two combined hormonal contraceptives with the same composition and different doses on female sexual function and plasma androgen levels","volume":"82","author":"Strufaldi","year":"2010","journal-title":"Contraception"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/00224499.2014.976780","article-title":"Cycle-Related Changes in Mood, Sexual Desire, and Sexual Activity in Oral Contraception-Using and Nonhormonal-Contraception-Using Couples","volume":"53","author":"Elaut","year":"2016","journal-title":"J. Sex Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1743-6109.2011.02266.x","article-title":"Sexual Functioning in Women Using Levonorgestrel-Releasing Intrauterine Systems as Compared to Copper Intrauterine Devices","volume":"9","author":"Enzlin","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_48","first-page":"115","article-title":"A study on the relationship of sexual satisfaction and common contraceptive methods employed by the couples","volume":"15","author":"Toorzani","year":"2010","journal-title":"Iran. J. Nurs. Midwifery Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/1471-0528.12407","article-title":"Oral contraceptive use and risk of vulvodynia: a population-based longitudinal study","volume":"120","author":"Reed","year":"2013","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.fertnstert.2008.07.002","article-title":"Risk of urinary incontinence symptoms in oral contraceptive users: a national cohort study from the Swedish Twin Register","volume":"92","author":"Iliadou","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/13625187.2015.1077380","article-title":"The shorter, the better: A review of the evidence for a shorter contraceptive hormone-free interval","volume":"21","author":"Graziottin","year":"2016","journal-title":"Eur. J. Contracept. Reprod. Heal. Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00404-014-3323-4","article-title":"Sexual life impact evaluation of different hormonal contraceptives on the basis of their methods of administration","volume":"290","author":"Guida","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_53","first-page":"1059","article-title":"Evaluation of quality of life and sexual functioning of women using levonorgestrel-releasing intrauterine contraceptive system--Mirena","volume":"32","author":"Skrzypulec","year":"2008","journal-title":"Coll. Antropol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/jsm.12409","article-title":"Hormonal contraception and female pain, orgasm and sexual pleasure","volume":"11","author":"Smith","year":"2014","journal-title":"J. Sex. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.contraception.2015.01.002","article-title":"Benchmark pregnancy rates and the assessment of post-coital contraceptives: an update","volume":"91","author":"Li","year":"2015","journal-title":"Contraception"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.fertnstert.2008.09.066","article-title":"Sexual function in first-time contraceptive ring and contraceptive patch users","volume":"93","author":"Gracia","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijgo.2011.03.008","article-title":"Combined contraceptive ring versus combined oral contraceptive (30-\u03bcg ethinylestradiol and 3-mg drospirenone)","volume":"114","author":"Mohamed","year":"2011","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/jsm.12392","article-title":"Clitoral vascularization and sexual behavior in young patients treated with drospirenone-ethinyl estradiol or contraceptive vaginal ring: a prospective, randomized, pilot study","volume":"11","author":"Battaglia","year":"2014","journal-title":"J. Sex. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/humrep\/deh686","article-title":"Effects of two types of hormonal contraception\u2014oral versus intravaginal\u2014on the sexual life of women and their partners","volume":"20","author":"Guida","year":"2005","journal-title":"Hum. Reprod."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1745-7599.2004.tb00444.x","article-title":"Nondaily hormonal contraception: considerations in contraceptive choice and patient counseling","volume":"16","author":"Freeman","year":"2004","journal-title":"J. Am. Acad. Nurse Pract."},{"key":"ref_61","first-page":"41","article-title":"Association of E2v\/DNG as contraceptive choice for a better quality of life of women","volume":"64","author":"Nappi","year":"2012","journal-title":"Minerva Ginecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/jsm.12022","article-title":"Women\u2019s perceptions about lubricant use and vaginal wetness during sexual activities","volume":"10","author":"Jozkowski","year":"2013","journal-title":"J. Sex. Med."},{"key":"ref_63","first-page":"525","article-title":"Transdermal delivery of sex steroids for hormone replacement therapy and contraception. A review of principles and practice","volume":"48","author":"Henzl","year":"2003","journal-title":"J. Reprod. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/6\/908\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:01:02Z","timestamp":1760187662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/6\/908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":63,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["jcm8060908"],"URL":"https:\/\/doi.org\/10.3390\/jcm8060908","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,25]]}}}