{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:19:44Z","timestamp":1787066384240,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL-075675"],"award-info":[{"award-number":["R01 HL-075675"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1 RR024146"],"award-info":[{"award-number":["UL1 RR024146"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HI 2113\/1-1"],"award-info":[{"award-number":["HI 2113\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>ApoCIII and triglyceride (TG)-rich lipoproteins (TRL), particularly, large TG-rich lipoproteins particles, have been described as important mediators of cardiovascular disease (CVD) risk. The effects of sustained consumption of dietary fructose compared with those of sustained glucose consumption on circulating apoCIII and large TRL particles have not been reported. We measured apoCIII concentrations and the TG and cholesterol content of lipoprotein subfractions separated by size in fasting and postprandial plasma collected from men and women (age: 54 \u00b1 8 years) before and after they consumed glucose- or fructose-sweetened beverages for 10 weeks. The subjects consuming fructose exhibited higher fasting and postprandial plasma apoCIII concentrations than the subjects consuming glucose (p &lt; 0.05 for both). They also had higher concentrations of postprandial TG in all TRL subfractions (p &lt; 0.05, effect of sugar), with the highest increases occurring in the largest TRL particles (p &lt; 0.0001 for fructose linear trend). Compared to glucose consumption, fructose consumption increased postprandial TG in low-density lipoprotein (LDL) particles (p &lt; 0.05, effect of sugar), especially in the smaller particles (p &lt; 0.0001 for fructose linear trend). The increases of both postprandial apoCIII and TG in large TRL subfractions were associated with fructose-induced increases of fasting cholesterol in the smaller LDL particles. In conclusion, 10 weeks of fructose consumption increased the circulating apoCIII and postprandial concentrations of large TRL particles compared with glucose consumption.<\/jats:p>","DOI":"10.3390\/jcm8070913","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T07:24:17Z","timestamp":1561533857000},"page":"913","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of Fructose or Glucose on Circulating ApoCIII and Triglyceride and Cholesterol Content of Lipoprotein Subfractions in Humans"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-4707","authenticated-orcid":false,"given":"Bettina","family":"Hieronimus","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Griffen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Keim","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Western Human Nutrition Research Center, Davis, CA 95616, USA"},{"name":"Department of Nutrition, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Bremer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Berglund","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8510, Japan"},{"name":"Hidaka Hospital, Takasaki, Gunma 370-0001, Japan"},{"name":"General Internal Medicine, Kanazawa Medical University, Kanazawa 920-0265, Japan"},{"name":"Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo 350-0288, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Havel","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"},{"name":"Department of Nutrition, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-0914","authenticated-orcid":false,"given":"Kimber L.","family":"Stanhope","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"ref_1","unstructured":"World Heal Organ (WHO) (2014). 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