{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:46:47Z","timestamp":1787867207691,"version":"build-2784847793"},"reference-count":113,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Inpatients are threatened by global malnutrition, but also by specific micronutrient (i.e., trace element and vitamins) deficiencies that frequently are overseen in the differential diagnosis of major organ dysfunctions. Some of them are related to specific geographic risks (iodine, iron, selenium, zinc, vitamin A), while others are pathology related, and finally many are associated with specific feeding patterns, including low dose enteral feeding. Among the pathologies in which laboratory blood investigations should include a micronutrient outwork, anemia is in the front line, followed by obesity with bariatric surgery, chronic liver disease, kidney disease, inflammatory bowel disease, cardiomyopathies and heart failure. The micronutrients at the highest risk are iron, zinc, thiamine, vitamin B12 and vitamin C. Admission to hospital has been linked with an additional risk of malnutrition\u2014feeding below 1500 kcal\/day was frequent and has been associated with a structural additional risk of insufficient micronutrient intake to cover basal needs. Although not evidence based, systematic administration of liberal thiamine doses upon admission, and daily complementation of inpatients\u2019 food and enteral feeding solutions with multi-micronutrient tablets might be considered.<\/jats:p>","DOI":"10.3390\/jcm8070931","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T11:20:26Z","timestamp":1561720826000},"page":"931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Micronutrient Deficiencies in Medical and Surgical Inpatients"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-1648","authenticated-orcid":false,"given":"Mette M","family":"Berger","sequence":"first","affiliation":[{"name":"Service of Adult Intensive Care Medicine and Burns, Lausanne University Hospital (CHUV), BH 08.612, Rue du Bugnon 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-8947","authenticated-orcid":false,"given":"Olivier","family":"Pantet","sequence":"additional","affiliation":[{"name":"Service of Adult Intensive Care Medicine and Burns, Lausanne University Hospital (CHUV), BH 08.612, Rue du Bugnon 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Schneider","sequence":"additional","affiliation":[{"name":"Service of Adult Intensive Care Medicine and Burns, Lausanne University Hospital (CHUV), BH 08.612, Rue du Bugnon 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-5223","authenticated-orcid":false,"given":"Nawfel","family":"Ben-Hamouda","sequence":"additional","affiliation":[{"name":"Service of Adult Intensive Care Medicine and Burns, Lausanne University Hospital (CHUV), BH 08.612, Rue du Bugnon 46, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM criteria for the diagnosis of malnutrition\u2014A consensus report from the global clinical nutrition community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_2","unstructured":"Allen, L., de Benoist, B., Dary, O., and Hurrel, R. (2006). Guidelines on food fortification with micronutrients. World Health Organization (WHO) Food and Agricultural Organization (FAO) of the United Nations, WHO. Available online: http:\/\/www.who.int\/nutrition\/publications\/guide_food_fortification_micronutrients.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-8223(01)00078-5","article-title":"Dietary reference intakes: Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc","volume":"101","author":"Trumbo","year":"2001","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(18)32776-4","article-title":"Individualised nutritional support in medical inpatients at nutritional risk: A randomised clinical trial","volume":"393","author":"Schuetz","year":"2019","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.clnesp.2015.04.003","article-title":"The economic cost of hospital malnutrition in Europe; a narrative review","volume":"10","year":"2015","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clnu.2007.10.007","article-title":"Prognostic impact of disease-related malnutrition","volume":"27","author":"Norman","year":"2008","journal-title":"Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clnu.2007.11.001","article-title":"Prevalence of malnutrition in paediatric hospital patients","volume":"27","author":"Pawellek","year":"2008","journal-title":"Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fnut.2017.00050","article-title":"Malnutrition upon Hospital Admission in Geriatric Patients: Why Assess It?","volume":"4","author":"Orlandoni","year":"2017","journal-title":"Front. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/MCO.0000000000000336","article-title":"Anorexia of aging and its role for frailty","volume":"20","author":"Sanford","year":"2017","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_10","unstructured":"(2000). World Health Organisation. Nutrition for Health and Development: A Global Agenda for Combating Malnutrition, WHO. Docemunt WHO\/NHD\/00.6."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/03670244.2017.1406855","article-title":"Nutrient Intake and Factors Influencing Eating Behaviors in Older Migrant Women Living in the United Kingdom","volume":"57","author":"Redwood","year":"2018","journal-title":"Ecol. Food Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000354932","article-title":"Global distribution and disease burden related to micronutrient deficiencies","volume":"78","author":"Black","year":"2014","journal-title":"Nestle Nutr. Inst. Workshop Ser."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-4290(98)00130-0","article-title":"Mapping soil micronutrients","volume":"60","author":"White","year":"1999","journal-title":"Field Crop. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/156482650702800201","article-title":"The human and economic cost of hidden hunger","volume":"28","author":"Stein","year":"2007","journal-title":"Food Nutr. Bull."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1038\/sj.ejcn.1601820","article-title":"Micronutrient deficiencies in developing and affluent countries","volume":"57","author":"Diaz","year":"2003","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_16","unstructured":"World Health Orgniasation (2019, April 25). Micronutrients. Available online: https:\/\/www.who.int\/nutrition\/topics\/micronutrients\/en\/."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S2213-8587(14)70225-6","article-title":"Iodine deficiency and thyroid disorders","volume":"3","author":"Zimmermann","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"565S","DOI":"10.1093\/jn\/131.2.565S","article-title":"Defining iron-deficiency anemia in public health terms: A time for reflection","volume":"131","author":"Stoltzfus","year":"2001","journal-title":"J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia","volume":"367","author":"Lopez","year":"2016","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2018-05-815944","article-title":"Iron deficiency","volume":"133","author":"Camaschella","year":"2019","journal-title":"Blood"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.59566\/IJBS.2011.7150","article-title":"High prevalence of Iron deficiency among educated hospital employees in Switzerland","volume":"7","author":"Schuepbach","year":"2011","journal-title":"Int. J. Biomed. Sci. IJBS"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/cc9992","article-title":"Iron deficiency in critically ill patients: Highlighting the role of hepcidin","volume":"15","author":"Heming","year":"2011","journal-title":"Crit. Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/CCM.0000000000001420","article-title":"Does IV Iron Induce Plasma Oxidative Stress in Critically Ill Patients? A comparison with healthy volunteers","volume":"44","author":"Lasocki","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3945\/ajcn.111.023812","article-title":"Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements","volume":"95","author":"Duncan","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1182\/blood-2011-02-337907","article-title":"Serum hepcidin: Reference ranges and biochemical correlates in the general population","volume":"117","author":"Galesloot","year":"2011","journal-title":"Blood"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1756283X11398736","article-title":"Diagnosis and management of iron deficiency anemia in the 21st century","volume":"4","author":"Graham","year":"2011","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ueda, N., and Takasawa, K. (2018). Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease. Nutrients, 10.","DOI":"10.3390\/nu10091173"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1136\/heartjnl-2014-305669","article-title":"Iron deficiency: An emerging therapeutic target in heart failure","volume":"100","author":"Leclercq","year":"2014","journal-title":"Heart"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s40572-018-0213-0","article-title":"Environmental Selenium and human health: An update","volume":"5","author":"Vinceti","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1073\/pnas.1611576114","article-title":"Selenium deficiency risk predicted to increase under future climate change","volume":"114","author":"Jones","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/CCM.0b013e31828a24c6","article-title":"The effect of selenium therapy on mortality in patients with sepsis syndrome: A systematic review and meta-analysis of randomized controlled trials","volume":"41","author":"Alhazzani","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1186\/cc6981","article-title":"Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma and subarachnoid hemorrhage patients","volume":"12","author":"Berger","year":"2008","journal-title":"Crit. Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1001\/jamainternmed.2016.2514","article-title":"Effect of sodium selenite administration and procalcitonin-guided therapy on mortality in patients with severe sepsis or septic shock: A randomized clinical trial","volume":"176","author":"Bloos","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/bmj.326.7386.409","article-title":"Zinc deficiency","volume":"326","author":"Prasad","year":"2003","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jtemb.2014.09.002","article-title":"Impact of the discovery of human zinc deficiency on health","volume":"28","author":"Prasad","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/ajcn\/85.3.837","article-title":"Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress","volume":"85","author":"Prasad","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Altarelli, M., Ben-Hamouda, N., Schneider, A., and Berger, M.M. (2019). Copper Deficiency\u2014Causes, Manifestations, and Treatment. Nutr. Clin. Prac.","DOI":"10.1002\/ncp.10328"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.nut.2016.09.012","article-title":"Massive copper and selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement","volume":"34","author":"Voirol","year":"2017","journal-title":"Nutrition"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1054S","DOI":"10.1093\/ajcn\/67.5.1054S","article-title":"Copper absorption and bioavailability","volume":"67","author":"Wapnir","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_42","unstructured":"World Health Organization (2012, August 30). The Global Burden of Disease: 2004 Update. 1. Cost of Illness. 2. World Health\u2014Statistics. 3. Mortality\u2014Trends. Available online: http:\/\/www.who.int\/healthinfo\/global_burden_disease\/GBD_report_2004update_full.pdf."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"R304","DOI":"10.1530\/EC-18-0184","article-title":"Vitamin D and critical illness: What endocrinology can learn from intensive care and vice versa","volume":"7","author":"Amrein","year":"2018","journal-title":"Endocr. Connect."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"116.e111\u2013116.e134","DOI":"10.1016\/j.amjmed.2015.06.034","article-title":"Screening and Treatment of Vitamin D Deficiency on Hospital Admission: Is There a Benefit for Medical Inpatients?","volume":"129","author":"Gradel","year":"2016","journal-title":"Am. J. Med."},{"key":"ref_45","first-page":"39","article-title":"Neither vitamin D levels nor supplementation are associated with the development of persistent critical illness: A retrospective cohort analysis","volume":"21","author":"Viglianti","year":"2019","journal-title":"Crit. Care Resusc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.nutr.20.1.395","article-title":"Alcohol: Its metabolism and interaction with nutrients","volume":"20","author":"Lieber","year":"2000","journal-title":"Annu. Rev. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/ajcn\/69.6.1071","article-title":"Alcohol, vitamin A, and beta-carotene: Adverse interactions, including hepatotoxicity and carcinogenicity","volume":"69","author":"Leo","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1749-6632.1982.tb31206.x","article-title":"Thiamin deficiency and alcoholism","volume":"378","author":"Leevy","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_49","first-page":"112","article-title":"Thiamin treatment and working memory function of alcohol-dependent people: Preliminary findings","volume":"25","author":"Ambrose","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ajem.2007.10.003","article-title":"Vitamin deficiencies in acutely intoxicated patients in the ED","volume":"26","author":"Li","year":"2008","journal-title":"Am. J. Emerg. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.3346\/jkms.2015.30.12.1874","article-title":"Vitamin C deficiency of Korean homeless vatients visiting to Emergency Department with acute alcohol intoxication","volume":"30","author":"Lee","year":"2015","journal-title":"J. Korean Med Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12939-017-0564-4","article-title":"Nutritional deficiencies in homeless persons with problematic drinking: A systematic review","volume":"16","author":"Ijaz","year":"2017","journal-title":"Int. J. Equity Health"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12011-017-1113-0","article-title":"Effect of Disturbances of Zinc and Copper on the Physical and Mental Health Status of Patients with Alcohol Dependence","volume":"183","author":"Ordak","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.drugalcdep.2013.07.035","article-title":"Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence","volume":"133","author":"Manzardo","year":"2013","journal-title":"Drug Alcohol. Depend."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1182\/blood-2016-10-569186","article-title":"Vitamin B12 deficiency from the perspective of a practicing hematologist","volume":"129","author":"Green","year":"2017","journal-title":"Blood"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00277-018-3407-5","article-title":"Copper deficiency anemia: Review article","volume":"97","author":"Myint","year":"2018","journal-title":"Ann. Hematol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0954422418000112","article-title":"A review of select minerals influencing the haematopoietic process","volume":"31","author":"Oliveira","year":"2018","journal-title":"Nutr. Res. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the cardiomyopathies: A position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"29","author":"Elliott","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/pgmj.70.821.235","article-title":"Selenium deficiency, reversible cardiomyopathy and short-term intravenous feeding","volume":"70","author":"Levy","year":"1994","journal-title":"Postgrad. Med. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0016-5085(82)80208-4","article-title":"Selenium deficiency and fatal cardiomyopathy in a patient on home parenteral nutrition","volume":"83","author":"Fleming","year":"1982","journal-title":"Gastroenterology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/002580240204200103","article-title":"Fulminant heart failure due to selenium deficiency cardiomyopathy (Keshan disease)","volume":"42","author":"Burke","year":"2002","journal-title":"Med. Sci. Law"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jtemb.2014.09.011","article-title":"Selenium deficiency associated porcine and human cardiomyopathies","volume":"31","author":"Wisloff","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12937-015-0039-7","article-title":"Shoshin Beriberi in Critically-Ill patients: Case series","volume":"14","author":"Dabar","year":"2015","journal-title":"Nutr. J."},{"key":"ref_65","first-page":"2335","article-title":"Hyperlactatemia and lactic acidosis in the critically ill patient","volume":"9","author":"Haesler","year":"2013","journal-title":"Rev. Med. Suisse"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ajem.2006.05.008","article-title":"Thiamine for the treatment of acute decompensated heart failure","volume":"25","author":"Smithline","year":"2007","journal-title":"Am. J. Emerg. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.ecl.2017.07.009","article-title":"Role of Vitamin D in Cardiovascular Diseases","volume":"46","author":"Rai","year":"2017","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/2277-9175.125812","article-title":"Nutritional status in patients with ulcerative colitis in Isfahan, Iran","volume":"3","author":"Kalantari","year":"2014","journal-title":"Adv. Biomed. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S0029665109001025","article-title":"Symposium on The challenge of translating nutrition research into public health nutrition. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on \u2018Nutrition and autoimmune disease\u2019. Nutrition in Crohn\u2019s disease","volume":"68","year":"2009","journal-title":"Proc. Nutr. Soc."},{"key":"ref_70","first-page":"432","article-title":"Serum vitamins A and E deficiencies in patients with inflammatory bowel disease","volume":"34","author":"Hashemi","year":"2013","journal-title":"Saudi Med. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1007\/s10620-015-3727-4","article-title":"Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases","volume":"60","author":"Torki","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1038\/srep04768","article-title":"Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease","volume":"4","author":"Nowak","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3109\/00365521.2013.836752","article-title":"Should we monitor vitamin B12 and folate levels in Crohn\u2019s disease patients?","volume":"48","author":"Bermejo","year":"2013","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s004150170270","article-title":"Wernicke\u2019s encephalopathy in a patient with Crohn\u2019s disease: A pathological study","volume":"248","author":"Larnaout","year":"2001","journal-title":"J. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.3390\/nu7042687","article-title":"Differential acute effects of selenomethionine and sodium selenite on the severity of colitis","volume":"7","author":"Hiller","year":"2015","journal-title":"Nutrients"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Saod, W.M., Darwish, N.T., Zaidan, T.A., and Alfalujie, A.W.A. (2017, January 20\u201321). Trace Elements in Sera of Patients with Hepatitis B: Determination and Analysis. Proceedings of the Advanced nanotechnology in engineering and medical sciences (ANEMS) \u2013 International conference 2017, Langkawi, Malaysia.","DOI":"10.1063\/1.5030883"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/0148607107031004311","article-title":"Nutrition assessment of patients with inflammatory bowel disease","volume":"31","author":"Vagianos","year":"2007","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Himoto, T., and Masaki, T. (2018). Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease. Nutrients, 10.","DOI":"10.3390\/nu10010088"},{"key":"ref_79","first-page":"OC25","article-title":"Correlation of Trace Elements in Patients of Chronic Liver Disease with Respect to Child- Turcotte- Pugh Scoring System","volume":"11","author":"Agarwal","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3177\/jnsv.53.213","article-title":"Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon alpha-2b and ribavirin","volume":"53","author":"Murakami","year":"2007","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1055\/s-2007-1007349","article-title":"Nutritional therapy in alcoholic liver disease","volume":"13","author":"Schenker","year":"1993","journal-title":"Semin. Liver Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.clinbiochem.2003.08.004","article-title":"Significance of elevated cobalamin (vitamin B12) levels in blood","volume":"36","author":"Ermens","year":"2003","journal-title":"Clin. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1055\/s-2007-1007365","article-title":"Management of osteopenia of liver disease with special emphasis on primary biliary cirrhosis","volume":"13","author":"Lindor","year":"1993","journal-title":"Semin. Liver Dis."},{"key":"ref_84","first-page":"297","article-title":"Vitamin D deficiency in patients with liver cirrhosis","volume":"29","author":"Konstantakis","year":"2016","journal-title":"Ann. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jhep.2012.04.033","article-title":"D-livering the message: The importance of vitamin D status in chronic liver disease","volume":"57","author":"Kitson","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/0884533617712226","article-title":"Micronutrient Deficiencies After Bariatric Surgery: An Emphasis on Vitamins and Trace Minerals [Formula: See text]","volume":"32","author":"Patel","year":"2017","journal-title":"Nutr. Clin. Pract."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/MCO.0000000000000352","article-title":"Nutrient deficiencies prior to bariatric surgery","volume":"20","author":"Roust","year":"2017","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1212\/01.wnl.0000256812.29648.86","article-title":"Wernicke encephalopathy after obesity surgery: A systematic review","volume":"68","author":"Singh","year":"2007","journal-title":"Neurology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/mus.20394","article-title":"Neurologic complications after surgery for obesity","volume":"33","author":"Koffman","year":"2006","journal-title":"Muscle Nerve"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.soard.2016.12.018","article-title":"American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrient","volume":"13","author":"Parrott","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Jankowska, M., Rutkowski, B., and Debska-Slizien, A. (2017). Vitamins and Microelement Bioavailability in Different Stages of Chronic Kidney Disease. Nutrients, 9.","DOI":"10.3390\/nu9030282"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"246","DOI":"10.5414\/CN109474","article-title":"Treatment of iron deficiency in patients with chronic kidney disease: A prospective observational study of iron isomaltoside (NIMO Scandinavia)","volume":"91","author":"Jensen","year":"2019","journal-title":"Clin. Nephrol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1515\/cclm-2013-0769","article-title":"Hepcidin levels in chronic hemodialysis patients: A critical evaluation","volume":"52","author":"Valenti","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/bs.vh.2019.01.012","article-title":"Hepcidin in chronic kidney disease anemia","volume":"110","author":"Ribeiro","year":"2019","journal-title":"Vitam. Horm."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Cozzolino, M., Mangano, M., Galassi, A., Ciceri, P., Messa, P., and Nigwekar, S. (2019). Vitamin K in Chronic Kidney Disease. Nutrients, 11.","DOI":"10.3390\/nu11010168"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Hou, Y.C., Lu, C.L., Zheng, C.M., Chen, R.M., Lin, Y.F., Liu, W.C., Yen, T.H., Chen, R., and Lu, K.C. (2019). Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The aspect of passive calcification. Nutrients, 11.","DOI":"10.3390\/nu11010152"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02783185","article-title":"Reversal of selenium and zinc deficiencies in chronic hemodialysis patients by intravenous sodium selenite and zinc gluconate supplementation\u2014Time-course of glutathione peroxidase repletion and lipid peroxidation decrease","volume":"39","author":"Richard","year":"1993","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2215\/CJN.11451017","article-title":"Concentrations of Trace Elements and Clinical Outcomes in Hemodialysis Patients: A prospective cohort study","volume":"13","author":"Tonelli","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_99","first-page":"81S","article-title":"Trace element balances during continuous venovenous hemodiafiltration (CVVHD)","volume":"6","author":"Berger","year":"2003","journal-title":"Kardiovasc. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3945\/ajcn.116.137125","article-title":"To eat or not to eat? Indicators for reduced food intake in 91,245 patients hospitalized on nutritionDays 2006\u20132014 in 56 countries worldwide: A descriptive analysis","volume":"104","author":"Schindler","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1007\/s00134-009-1567-4","article-title":"The relationship between nutritional intake and clinical outcomes in critically ill patients: Results of an international multicenter observational study","volume":"35","author":"Alberda","year":"2009","journal-title":"Intensive Care Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clnu.2018.08.037","article-title":"ESPEN Guidelines: Nutrition in the ICU","volume":"38","author":"Singer","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jcsm.12260","article-title":"Vitamin B12 deficiency and impaired expression of amnionless during aging","volume":"9","author":"Pannerec","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.clnu.2015.12.010","article-title":"Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial","volume":"35","author":"Deutz","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.nut.2016.05.016","article-title":"Revisiting the refeeding syndrome: Results of a systematic review","volume":"35","author":"Friedli","year":"2017","journal-title":"Nutrition"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Sauer, A., Goates, S., Malone, A., Mogensen, K., Gewirtz, G., Sulz, I., Moick, S., Laviano, A., and Hiesmayr, M. (2019). Prevalence of Malnutrition Risk and the Impact of Nutrition Risk on Hospital Outcomes: Results From nutritionDay in the U.S. JPEN. J. Parenter. Enter. Nutr.","DOI":"10.1016\/j.clnu.2018.06.2016"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000499039","article-title":"Thiamine Substitution in Alcohol Use Disorder: A Narrative Review of Medical Guidelines","volume":"25","author":"Pruckner","year":"2019","journal-title":"Eur. Addict. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.clnu.2016.09.009","article-title":"Costs of hospital malnutrition","volume":"36","author":"Curtis","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1001\/archinte.164.21.2335","article-title":"The SU.VI.MAX Study: A randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals","volume":"164","author":"Hercberg","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.nut.2010.12.009","article-title":"Micronutrient supplementation for critically ill adults: A systematic review and meta-analysis","volume":"27","author":"Visser","year":"2011","journal-title":"Nutrition"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/0379572117720012","article-title":"Societal costs of micronutrient deficiencies in 6- to 59-month-old children in Pakistan","volume":"38","author":"Wieser","year":"2017","journal-title":"Food Nutr. Bull."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.clnu.2018.07.009","article-title":"Monitoring nutrition in the ICU","volume":"38","author":"Berger","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.clnu.2014.04.012","article-title":"Trace element monitoring in the ICU: Quality and economic impact of a change in sampling practice","volume":"34","author":"Gagnon","year":"2014","journal-title":"Clin. Nutr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/7\/931\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:02:04Z","timestamp":1760187724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/7\/931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,28]]},"references-count":113,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["jcm8070931"],"URL":"https:\/\/doi.org\/10.3390\/jcm8070931","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,28]]}}}