{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:42:46Z","timestamp":1760240566871,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["1002627E033001, 1072321B006008","105-2628-B-006-003-MY3 to W.T.C.","101-2314-B\u20146-031, 102-2314-B-006-018, 103-2314-B-006-077","972314B006018MY2, 106-2218-E-006-020"],"award-info":[{"award-number":["1002627E033001, 1072321B006008","105-2628-B-006-003-MY3 to W.T.C.","101-2314-B\u20146-031, 102-2314-B-006-018, 103-2314-B-006-077","972314B006018MY2, 106-2218-E-006-020"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","award":["B106-K028, B107-K048"],"award-info":[{"award-number":["B106-K028, B107-K048"]}],"id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["10703019","10506007 to J.N.W.","10705004 to C.D.K."],"award-info":[{"award-number":["10703019","10506007 to J.N.W.","10705004 to C.D.K."]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center of Applied Nanomedicine, National Cheng Kung University from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan","award":["to T.W.W."],"award-info":[{"award-number":["to T.W.W."]}]},{"name":"Focused Investment Scheme and Li Ka Shing Institute of Health Science of the Chinese University of Hong Kong","award":["to H.C.C."],"award-info":[{"award-number":["to H.C.C."]}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["466710 to X.J."],"award-info":[{"award-number":["466710 to X.J."]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Human cardiac progenitor cells isolated from the same host may have advantages over other sources of stem cells. The aim of this study is to establish a new source of human progenitor cells collected from a waste product, pericardiac effusion fluid, after open-heart surgery in children with congenital heart diseases. The fluid was collected every 24 h for 2 days after surgery in 37 children. Mononuclear cells were isolated and expanded in vitro. These pericardial effusion-derived progenitor cells (PEPCs) exhibiting cardiogenic lineage markers, were highly proliferative and enhanced angiogenesis in vitro. Three weeks after stem cell transplantation into the ischemic heart in mice, cardiac ejection fraction was improved significantly without detectable progenitor cells. Gene expression profiles of the repaired hearts revealed activation of several known repair mechanisms including paracrine effects, cell migration, and angiogenesis. These progenitor cells may have the potential for heart regeneration.<\/jats:p>","DOI":"10.3390\/jcm8071028","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T11:49:38Z","timestamp":1562932178000},"page":"1028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progenitor Cells Derived from Drain Waste Product of Open-Heart Surgery in Children"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-7339","authenticated-orcid":false,"given":"Tak-Wah","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan"},{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan"},{"name":"Center of Applied Nanomedicine, National Cheng Kung University, Tainan 701, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Dann","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Cardiovascular Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0310-0675","authenticated-orcid":false,"given":"Wen-Tai","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin Lam","family":"Fok","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye Chun","family":"Ruan","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong"},{"name":"Key Laboratory for Regenerative Medicine, Ministry of Education of the People\u2019s Republic of China, Shatin, HongKong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong 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