{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:01:19Z","timestamp":1791820879005,"version":"4.3.4"},"reference-count":44,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Based on civil registries, 26,000 people died from alcoholic cardiomyopathy (ACM) in 2015 globally. In the Global Burden of Disease (GBD) 2017 study, garbage coded deaths were redistributed to ACM, resulting in substantially higher ACM mortality estimates (96,669 deaths, 95% confidence interval: 82,812\u201397,507). We aimed to explore the gap between civil registry and GBD mortality data, accounting for alcohol exposure as a cause of ACM. Methods: ACM mortality rates were obtained from civil registries and GBD for n = 77 countries. The relationship between registered and estimated mortality rates was assessed by sex and age groups, using Pearson correlation coefficients, in addition to comparing mortality rates with population alcohol exposure\u2014the underlying cause of ACM. Results: Among people aged 65 years or older, civil registry mortality rates of ACM decreased markedly whereas GBD mortality rates increased. The widening gap of registered and estimated mortality rates in the elderly is reflected in a decrease of correlations. The age distribution of alcohol exposure is more consistent with the distribution of civil registry rather than GBD mortality rates. Conclusions: Among older adults, GBD mortality estimates of ACM seem implausible and are inconsistent with alcohol exposure. The garbage code redistribution algorithm should include alcohol exposure for ACM and other alcohol-attributable diseases.<\/jats:p>","DOI":"10.3390\/jcm8081137","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T11:37:07Z","timestamp":1564573027000},"page":"1137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mortality from Alcoholic Cardiomyopathy: Exploring the Gap between Estimated and Civil Registry Data"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-3760","authenticated-orcid":false,"given":"Jakob","family":"Manthey","sequence":"first","affiliation":[{"name":"Institute of Clinical Psychology and Psychotherapy, TU Dresden, Chemnitzer Str. 46, 01187 Dresden, Germany"},{"name":"Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistra\u00dfe 52, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-0385","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Rehm","sequence":"additional","affiliation":[{"name":"Institute of Clinical Psychology and Psychotherapy, TU Dresden, Chemnitzer Str. 46, 01187 Dresden, Germany"},{"name":"Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistra\u00dfe 52, 20246 Hamburg, Germany"},{"name":"Institute for Mental Health Policy Research, CAMH, 33 Russell Street, Toronto, ON M5S 2S1, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, 155 College Street, 6th Floor, Toronto, ON M5T 3M7, Canada"},{"name":"Campbell Family Mental Health Research Institute, CAMH, 250 College Street, Toronto, ON M5T 1R8, Canada"},{"name":"Institute of Medical Science (IMS), University of Toronto, Medical Sciences Building, 1 King\u2019s College Circle, Room 2374, Toronto, ON M5S 1A8, Canada"},{"name":"Department of Psychiatry, University of Toronto, 250 College Street, 8th Floor, Toronto, ON M5T 1R8, Canada"},{"name":"WHO Collaborating Centre for Mental Health and Addiction, 33 Russell Street, Toronto, ON M5S 2S1, Canada"},{"name":"Department of International Health Projects, Institute for Leadership and Health Management, I.M. Sechenov First Moscow State Medical University, Trubetskaya str., 8, b. 2, Moscow 119992, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.tcm.2017.06.002","article-title":"Cardiovascular effects of alcohol consumption","volume":"27","author":"Rehm","year":"2017","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pcad.2018.02.001","article-title":"Alcohol and CV Health: Jekyll and Hyde J-Curves","volume":"61","author":"DiNicolantonio","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2017.06.014","article-title":"Alcoholic cardiomyopathy: What is known and what is not known","volume":"43","author":"Mirijello","year":"2017","journal-title":"Eur. J. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(16)31713-5","article-title":"Dilated cardiomyopathy","volume":"390","author":"Weintraub","year":"2017","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4330\/wjc.v6.i8.771","article-title":"Alcoholic cardiomyopathy","volume":"6","year":"2014","journal-title":"World J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12012-014-9252-4","article-title":"Alcoholic cardiomyopathy: Pathophysiologic insights","volume":"14","author":"Piano","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.alcohol.2017.01.011","article-title":"Quantifying the contribution of alcohol to cardiomyopathy: A systematic review","volume":"61","author":"Rehm","year":"2017","journal-title":"Alcohol"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Manthey, J., Imtiaz, S., Neufeld, M., Rylett, M., and Rehm, J. (2017). Quantifying the global contribution of alcohol consumption to cardiomyopathy. Popul. Health Metr., 15.","DOI":"10.1186\/s12963-017-0137-1"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0140-6736(15)60171-4","article-title":"A global assessment of civil registration and vital statistics systems: Monitoring data quality and progress","volume":"386","author":"Mikkelsen","year":"2015","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1136\/heartjnl-2017-312384","article-title":"National, regional and global mortality due to alcoholic cardiomyopathy in 2015","volume":"104","author":"Manthey","year":"2018","journal-title":"Heart"},{"key":"ref_11","unstructured":"Institute for Health Metrics and Evaluation (2018). GBD Results Tool, University of Washington."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Roth","year":"2018","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1478-7954-8-9","article-title":"Algorithms for enhancing public health utility of national causes-of-death data","volume":"8","author":"Naghavi","year":"2010","journal-title":"Popul. Health Metr."},{"key":"ref_14","unstructured":"Murray, C.J.L., Lopez, A.D., World Health Organization, World Bank, and Harvard School of Public Health (1996). The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020, Harvard School of Public Health on behalf of the World Health Organization and the World Bank."},{"key":"ref_15","unstructured":"World Health Organization (1993). The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research, World Health Organization."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1478-7954-12-10","article-title":"Redistribution of heart failure as the cause of death: The Atherosclerosis Risk in Communities Study","volume":"12","author":"Snyder","year":"2014","journal-title":"Popul. Health Metr."},{"key":"ref_17","first-page":"204","article-title":"Is the Mortality Trend of Ischemic Heart Disease by the GBD2013 Study in China Real?","volume":"30","author":"Wan","year":"2017","journal-title":"Biomed. Environ. Sci."},{"key":"ref_18","unstructured":"World Health Organisation (2018). WHO Mortality Database, World Health Organisation."},{"key":"ref_19","unstructured":"Institute for Health Metrics and Evaluation (2018). Global Burden of Disease Study 2017 (GBD 2017) Causes of Death and Nonfatal Causes Mapped to ICD Codes, Institute for Health Metrics and Evaluation."},{"key":"ref_20","unstructured":"Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat (2017). World Population Prospects: The 2017 Revision, Key Findings and Advance Tables, Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0140-6736(18)32744-2","article-title":"Alcohol exposure between 1990 and 2017 and forecasts until 2030: A global modeling study","volume":"393","author":"Manthey","year":"2019","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-7954-9-8","article-title":"Improving the public health utility of global cardiovascular mortality data: The rise of ischemic heart disease","volume":"9","author":"Ahern","year":"2011","journal-title":"Popul. Health Metr."},{"key":"ref_24","unstructured":"Team, R.C. (2018). R: A Language and Environment for Statistical Computing, 3.5.1, R Foundation for Statistical Computing."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/clc.23067","article-title":"National trends in hospitalizations and outcomes in patients with alcoholic cardiomyopathy","volume":"41","author":"Ram","year":"2018","journal-title":"Clin. Cardiol."},{"key":"ref_26","unstructured":"World Health Organization (2018). Global Status Report on Alcohol and Health 2018, WHO Press."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/add.13757","article-title":"The relationship between different dimensions of alcohol use and the burden of disease-an update","volume":"112","author":"Rehm","year":"2017","journal-title":"Addiction"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jchf.2014.07.014","article-title":"Natural history and prognostic factors in alcoholic cardiomyopathy","volume":"3","author":"Segovia","year":"2015","journal-title":"JACC Heart Fail"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1053\/euhj.1999.1761","article-title":"Comparison of long-term outcome of alcoholic and idiopathic dilated cardiomyopathy","volume":"21","author":"Fauchier","year":"2000","journal-title":"Eur. Heart J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0735-1097(00)00565-9","article-title":"Early changes in left ventricular function in chronic asymptomatic alcoholics: Relation to the duration of heavy drinking","volume":"35","author":"Nakatani","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/oxfordjournals.eurheartj.a014842","article-title":"Differences of disease progression in congestive heart failure due to alcoholic as compared to idiopathic dilated cardiomyopathy","volume":"17","author":"Prazak","year":"1996","journal-title":"Eur. Heart J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1172\/JCI105997","article-title":"Ventricular function in noncardiacs with alcoholic fatty liver: Role of ethanol in the production of cardiomyopathy","volume":"48","author":"Regan","year":"1969","journal-title":"J. Clin. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0002-9149(91)90442-N","article-title":"Rarity of preclinical alcoholic cardiomyopathy in chronic alcoholics <40 years of age","volume":"67","author":"Cerqueira","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.drugalcdep.2014.11.029","article-title":"Delay to first treatment contact for alcohol use disorder","volume":"147","author":"Chapman","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12963-016-0082-4","article-title":"Improving the usefulness of US mortality data: New methods for reclassification of underlying cause of death","volume":"14","author":"Foreman","year":"2016","journal-title":"Popul. Health Metr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/alcalc\/agq089","article-title":"The stigma of alcohol dependence compared with other mental disorders: A review of population studies","volume":"46","author":"Schomerus","year":"2011","journal-title":"Alcohol Alcohol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/alcalc\/agx032","article-title":"Barriers to Alcohol Screening Among Hypertensive Patients and the Role of Stigma: Lessons for the Implementation of Screening and Brief Interventions in European Primary Care Settings","volume":"52","author":"Hanschmidt","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/S0140-6736(19)30706-8","article-title":"Alcohol and the global burden of disease\u2014Authors\u2019 reply","volume":"393","author":"Griswold","year":"2019","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/S0140-6736(19)30713-5","article-title":"Alcohol and the global burden of disease","volume":"393","author":"Abat","year":"2019","journal-title":"Lancet"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/S0140-6736(19)30726-3","article-title":"Alcohol and the global burden of disease","volume":"393","author":"Shield","year":"2019","journal-title":"Lancet"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1465-3362.2012.00475.x","article-title":"Lack of international consensus in low-risk drinking guidelines","volume":"32","author":"Furtwaengler","year":"2013","journal-title":"Drug Alcohol Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1001\/jama.1987.03400030061032","article-title":"Underreporting of Alcohol-Related Mortality on Death Certificates of Young US Army Veterans","volume":"258","author":"Pollock","year":"1987","journal-title":"JAMA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/009145090403100304","article-title":"Measuring alcohol consumption","volume":"31","author":"Gmel","year":"2004","journal-title":"Contempor. Drug Probl."},{"key":"ref_44","first-page":"244","article-title":"The World Health Organization\u2019s Global Monitoring System on Alcohol and Health","volume":"35","author":"Poznyak","year":"2013","journal-title":"Alcohol Res. Curr. Rev."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/8\/1137\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:11:39Z","timestamp":1760188299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/8\/1137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8]]}},"alternative-id":["jcm8081137"],"URL":"https:\/\/doi.org\/10.3390\/jcm8081137","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,31]]}}}