{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:59:18Z","timestamp":1787839158510,"version":"build-2784847793"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69\u201344.01; p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01\u20130.37; p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02\u20130.59; p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.<\/jats:p>","DOI":"10.3390\/jcm8091315","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T11:13:30Z","timestamp":1566904410000},"page":"1315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland"],"prefix":"10.3390","volume":"8","author":[{"given":"Stefan","family":"Grasl","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1161-4871","authenticated-orcid":false,"given":"Stefan","family":"Janik","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthaeus C.","family":"Grasl","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pammer","sequence":"additional","affiliation":[{"name":"Clinical Institute of Pathology, Medical University of Vienna, A-1097 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Formanek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Phonetics, Hospital of St. John of God, 1020 Vienna, Austria"},{"name":"Sigmund Freud University, Medical School, 1020 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayardo","family":"Perez-Ordonez","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-2863","authenticated-orcid":false,"given":"Andrew","family":"Hope","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hosni","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre\/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Irish","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre\/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre\/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre\/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-1056","authenticated-orcid":false,"given":"Boban M.","family":"Erovic","sequence":"additional","affiliation":[{"name":"Institute of Head and Neck Diseases, Evangelical Hospital Vienna, 1180 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Seifert, G., and Sobin, L.H. 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