{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:23:47Z","timestamp":1792218227346,"version":"4.4.0"},"reference-count":105,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions. In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) deposits and hypercellularity lesions (mesangial and\/or endocapillary) in the glomeruli. However, there is compelling evidence to suggest that glomerular epithelial cells, and podocytes in particular, are also involved in glomerular injury in patients with SLE. Podocytes now appear to be not only subject to collateral damage due to glomerular capillary lesions secondary to IC and inflammatory processes, but they are also a potential direct target in lupus nephritis. Improvements in our understanding of podocyte injury could improve the classification of lupus glomerulonephritis. Indeed, podocyte injury may be prominent in two major presentations: lupus podocytopathy and glomerular crescent formation, in which glomerular parietal epithelial cells play also a key role. We review here the contribution of podocyte impairment to different presentations of lupus nephritis, focusing on the podocyte signaling pathways involved in these lesions.<\/jats:p>","DOI":"10.3390\/jcm8091340","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T11:26:22Z","timestamp":1567077982000},"page":"1340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Podocyte Injury in Lupus Nephritis"],"prefix":"10.3390","volume":"8","author":[{"given":"Hamza","family":"Sakhi","sequence":"first","affiliation":[{"name":"AP-HP (Assistance Publique des H\u00f4pitaux de Paris), Department of Nephrology and Renal Transplantation, Groupe Hospitalier Henri-Mondor, 94010 Cr\u00e9teil, France"},{"name":"UPEC (Universit\u00e9 Paris Est Cr\u00e9teil), UMR-S955, 94010 Cr\u00e9teil, France"},{"name":"INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), \u00c9quipe 21, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-3979","authenticated-orcid":false,"given":"Anissa","family":"Moktefi","sequence":"additional","affiliation":[{"name":"UPEC (Universit\u00e9 Paris Est Cr\u00e9teil), UMR-S955, 94010 Cr\u00e9teil, France"},{"name":"INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), \u00c9quipe 21, 94010 Cr\u00e9teil, France"},{"name":"AP-HP (Assistance Publique des H\u00f4pitaux de Paris), Department of Pathology, Groupe Hospitalier Henri-Mondor, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khedidja","family":"Bouachi","sequence":"additional","affiliation":[{"name":"AP-HP (Assistance Publique des H\u00f4pitaux de Paris), Department of Nephrology and Renal Transplantation, Groupe Hospitalier Henri-Mondor, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-2550","authenticated-orcid":false,"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"AP-HP (Assistance Publique des H\u00f4pitaux de Paris), Department of Nephrology and Renal Transplantation, Groupe Hospitalier Henri-Mondor, 94010 Cr\u00e9teil, France"},{"name":"UPEC (Universit\u00e9 Paris Est Cr\u00e9teil), UMR-S955, 94010 Cr\u00e9teil, France"},{"name":"INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), \u00c9quipe 21, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-8662","authenticated-orcid":false,"given":"Carole","family":"H\u00e9nique","sequence":"additional","affiliation":[{"name":"UPEC (Universit\u00e9 Paris Est Cr\u00e9teil), UMR-S955, 94010 Cr\u00e9teil, France"},{"name":"INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), \u00c9quipe 21, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Remy","sequence":"additional","affiliation":[{"name":"AP-HP (Assistance Publique des H\u00f4pitaux de Paris), Department of Nephrology and Renal Transplantation, Groupe Hospitalier Henri-Mondor, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-706X","authenticated-orcid":false,"given":"Mario","family":"Ollero","sequence":"additional","affiliation":[{"name":"UPEC (Universit\u00e9 Paris Est Cr\u00e9teil), UMR-S955, 94010 Cr\u00e9teil, France"},{"name":"INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), \u00c9quipe 21, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"El Karoui","sequence":"additional","affiliation":[{"name":"AP-HP (Assistance Publique des H\u00f4pitaux de Paris), Department of Nephrology and Renal Transplantation, Groupe Hospitalier Henri-Mondor, 94010 Cr\u00e9teil, France"},{"name":"UPEC (Universit\u00e9 Paris Est Cr\u00e9teil), UMR-S955, 94010 Cr\u00e9teil, France"},{"name":"INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), \u00c9quipe 21, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2215\/CJN.05780616","article-title":"Update on Lupus Nephritis","volume":"12","author":"Almaani","year":"2017","journal-title":"Clin. 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