{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:53:50Z","timestamp":1788368030899,"version":"build-2803163510"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Retinitis Pigmentosa (RP) represents a retinal dystrophy with an extremely complex pathogenesis further worsened by the impairment of the retinal vascular supply. The main goal of this study was to identify different vascular patterns in RP, by means of optical coherence tomography angiography (OCTA). Methods: A total of 32 RP patients (16 males, 50%; mean age 45.93 \u00b1 11.4) and 32 healthy age-matched controls (16 males, 50%; age 42.8 \u00b1 11.2). High resolution OCT and OCTA images were obtained from all participants. Several quantitative parameters were extracted both from structural OCT and OCTA images. A post-hoc analysis assessed the relationship between the quantitative OCTA parameters adopted and the following measures: best corrected visual acuity (BCVA), central macular thickness (CMT) and retinal nerve fiber layer (RNFL). Results: Mean LogMAR BCVA was 0.24 \u00b1 0.32 for RP patients and 0.0 \u00b1 0.0 for controls (p &lt; 0.01). CMT, choroidal thickness and RNFL were statistically different between RP and controls (p &lt; 0.01). OCTA parameters showed strong alterations of the retinal vascular network in RP (all p &lt; 0.01). Several statistically significant correlations were also found. Furthermore, a vessel tortuosity cut-off of 4.80 and a vessel rarefaction cut-off of 0.62 enabled the RP cohort to be divided into two significantly different sub-groups in terms of BCVA, RNFL and CMT. Conclusions: Quantitative OCTA parameters help identify vascular abnormalities in RP, separating two different vascular patterns.<\/jats:p>","DOI":"10.3390\/jcm8091425","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T10:52:26Z","timestamp":1568112746000},"page":"1425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Vascular Patterns in Retinitis Pigmentosa on Swept-Source Optical Coherence Tomography Angiography"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-8414","authenticated-orcid":false,"given":"Alessandro","family":"Arrigo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Romano","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Biomedical and Clinical Science, Luigi Sacco University Hospital, 20157 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Albertini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Aragona","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-9682","authenticated-orcid":false,"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Battaglia Parodi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Dyonne","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4161\/cc.6.6.4029","article-title":"Programmed cell death in retinal degeneration: Targeting apoptosis in photoreceptors as potential therapy for retinal degeneration","volume":"6","author":"Marigo","year":"2007","journal-title":"Cell Cycle"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.preteyeres.2017.08.004","article-title":"The mechanism of cone cell death in Retinitis Pigmentosa","volume":"62","author":"Campochiaro","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_4","first-page":"1064","article-title":"Subfoveal choroidal blood flow and central retinal function in retinitis pigmentosa","volume":"5","author":"Falsini","year":"2011","journal-title":"IOVS"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/IAE.0000000000001301","article-title":"Dynamic and static vessel analysis in patients with retinitis pigmentosa: A pilot study of vascular diameters and functionality","volume":"37","author":"Iacono","year":"2017","journal-title":"Retina"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3249064","DOI":"10.1155\/2018\/3249064","article-title":"A Brief Review on the Pathological Role of Decreased Blood Flow Affected in Retinitis Pigmentosa","volume":"2018","author":"Yang","year":"2018","journal-title":"J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/bjophthalmol-2016-308925","article-title":"Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography","volume":"101","author":"Cicinelli","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1167\/iovs.16-20544","article-title":"Macular Features in Retinitis Pigmentosa: Correlations Among Ganglion Cell Complex Thickness, Capillary Density, and Macular Function","volume":"57","author":"Toto","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3389\/fneur.2017.00572","article-title":"Radial Peripapillary Capillary Network in Patients with Retinitis Pigmentosa: An Optical Coherence Tomography Angiography Study","volume":"8","author":"Mastropasqua","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Al-Sheikh, M., Ghasemi Falavarjani, K., Akil, H., and Sadda, S.R. (2017). Impact of image quality on OCT angiography based quantitative measurements. Int. J. Retina Vitreous, 13.","DOI":"10.1186\/s40942-017-0068-9"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ajo.2007.09.038","article-title":"A visual field index for calculation of glaucoma rate of progression","volume":"145","author":"Bengtsson","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/jemt.20829","article-title":"3D reconstruction of histological sections: Application to mammary gland tissue","volume":"73","year":"2010","journal-title":"Microsc. Res. Tech."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1109\/TMI.2007.904657","article-title":"A novel method for the automatic grading of retinal vessel tortuosity","volume":"27","author":"Grisan","year":"2008","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4103\/0976-500X.85931","article-title":"Measures of dispersion","volume":"2","author":"Manikandan","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1364\/AO.30.001369","article-title":"Scale space approach to directional analysis of images","volume":"30","author":"Liu","year":"1991","journal-title":"Appl. Opt."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biomaterials.2015.05.015","article-title":"DiameterJ: A validated open source nanofiber diameter measurement tool","volume":"61","author":"Hotaling","year":"2015","journal-title":"Biomaterials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1016\/j.biomaterials.2010.03.052","article-title":"Characterization of the complete fiber network topology of planar fibrous tissues and scaffolds","volume":"31","author":"Stella","year":"2010","journal-title":"Biomaterials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1021\/ie901179m","article-title":"Artificial Vision System for the Automatic Measurement of Interfiber Pore Characteristics and Fiber Diameter Distribution in Nanofiber Assemblies","volume":"49","author":"Tomba","year":"2010","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_20","unstructured":"Arrigo, A., Bandello, F., and Battaglia Parodi, M. (2019). Reproducibility and repeatability optical coherence tomography angiography coefficients, Unpublished work."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00417-015-3185-x","article-title":"Correlation of SD-OCT findings and visual function in patients with retinitis pigmentosa","volume":"254","author":"Triolo","year":"2016","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ajo.2018.08.001","article-title":"Advanced Optical Coherence Tomography Angiography Analysis of Age-related Macular Degeneration Complicated by Onset of Unilateral Choroidal Neovascularization","volume":"195","author":"Arrigo","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF02173368","article-title":"The relationship between retinal vessel tortuosity, diameter, and transmural pressure","volume":"224","author":"Kylstra","year":"1986","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.ophtha.2008.05.029","article-title":"The retinal vasculature as a fractal: Methodology, reliability, and relationship to blood pressure","volume":"115","author":"Liew","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_25","first-page":"29","article-title":"A two-Stage Hypothesis for the Natural Course of Retinitis Pigmentosa","volume":"Volume 62","author":"Zrenner","year":"1987","journal-title":"Research in Retinitis Pigmentosa"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1097\/IAE.0000000000000765","article-title":"Image artifacts in optical coherence tomography angiography","volume":"35","author":"Spaide","year":"2015","journal-title":"Retina"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/9\/1425\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:18:25Z","timestamp":1760188705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/9\/1425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["jcm8091425"],"URL":"https:\/\/doi.org\/10.3390\/jcm8091425","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]}}}