{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:10:37Z","timestamp":1790017837351,"version":"4.0.1"},"reference-count":154,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T00:00:00Z","timestamp":1568419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine, Medical University of Warsaw","award":["1M15\/N\/19"],"award-info":[{"award-number":["1M15\/N\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded.<\/jats:p>","DOI":"10.3390\/jcm8091468","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T03:17:57Z","timestamp":1568603877000},"page":"1468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["NK Cells as Potential Targets for Immunotherapy in Endometriosis"],"prefix":"10.3390","volume":"8","author":[{"given":"Aneta","family":"\u015acie\u017cy\u0144ska","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, Cha\u0142ubi\u0144skiego 5, 02-004 Warsaw, Poland"},{"name":"Laboratory for Experimental Immunology, Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-9992","authenticated-orcid":false,"given":"Micha\u0142","family":"Komorowski","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Immunology, Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Soszy\u0144ska","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Immunology, Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-8476","authenticated-orcid":false,"given":"Jacek","family":"Malejczyk","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Warsaw, Cha\u0142ubi\u0144skiego 5, 02-004 Warsaw, Poland"},{"name":"Laboratory for Experimental Immunology, Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0015-0282(97)00191-X","article-title":"Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities","volume":"68","author":"Nisolle","year":"1997","journal-title":"Fertil. Steril."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/er.2018-00242","article-title":"Endometriosis","volume":"40","author":"Bulun","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.fertnstert.2007.03.069","article-title":"Differences in characteristics among 1,000 women with endometriosis based on extent of disease","volume":"89","author":"Sinaii","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Broi, M.G.D., Ferriani, R.A., and Navarro, P.A. (2019). Ethiopathogenic mechanisms of endometriosis-related infertility. JBRA Assist. Reprod.","DOI":"10.5935\/1518-0557.20190029"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bpobgyn.2018.06.002","article-title":"Endometriosis and infertility: Insights into the causal link and management strategies","volume":"51","author":"Tomassetti","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s13669-017-0187-1","article-title":"Endometriosis: Epidemiology, Diagnosis and Clinical Management","volume":"6","author":"Parasar","year":"2017","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.fertnstert.2018.10.013","article-title":"Pathogenesis of endometriosis: The genetic\/epigenetic theory","volume":"111","author":"Koninckx","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Baranov, V., Malysheva, O., and Yarmolinskaya, M. (2018). Pathogenomics of Endometriosis Development. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071852"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/1573404813666170306163448","article-title":"Molecular and Cellular Pathogenesis of Endometriosis","volume":"14","author":"Klemmt","year":"2018","journal-title":"Curr. Womens Health Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: Pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-9378(15)30003-X","article-title":"Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity","volume":"14","author":"Sampson","year":"1927","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_14","first-page":"745","article-title":"Ueber den stand der frage der adenomyositis und adenomyome im allgemeinem und insbesondere ueber adenomyositis serosoepithelialis und adenomyometritis sarcomatosa","volume":"43","author":"Meyer","year":"1919","journal-title":"Zentralbibliothek Gynaecologie"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0002-9378(91)90255-P","article-title":"Secondary mullerian system and endometriosis","volume":"165","author":"Fujii","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1530\/rep.0.1230217","article-title":"Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis","volume":"123","author":"Gazvani","year":"2002","journal-title":"Reproduction"},{"key":"ref_17","first-page":"237","article-title":"Immunology of endometriosis","volume":"57","author":"Ulukus","year":"2005","journal-title":"Minerva Ginecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.molmed.2018.07.004","article-title":"The Immunopathophysiology of Endometriosis","volume":"24","author":"Symons","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1471-4914(03)00051-0","article-title":"Pathogenesis of endometriosis: Natural immunity dysfunction or autoimmune disease?","volume":"9","author":"Matarese","year":"2003","journal-title":"Trends Mol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.autrev.2012.01.005","article-title":"Is there an association between autoimmunity and endometriosis?","volume":"11","author":"Eisenberg","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.autrev.2018.03.017","article-title":"The link between immunity, autoimmunity and endometriosis: A literature update","volume":"17","author":"Zhang","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-2003-41323","article-title":"Apoptosis and the pathogenesis of endometriosis","volume":"21","author":"Arici","year":"2003","journal-title":"Semin. Reprod. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/humupd\/dmt010","article-title":"Endometriosis: Hormone regulation and clinical consequences of chemotaxis and apoptosis","volume":"19","author":"Reis","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00404-016-4195-6","article-title":"Regulation of apoptotic pathways during endometriosis: From the molecular basis to the future perspectives","volume":"294","author":"Vetvicka","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-2003-41324","article-title":"Cell adhesion molecules and endometriosis","volume":"21","author":"Witz","year":"2003","journal-title":"Semin. Reprod. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-2003-41322","article-title":"Matrix metalloproteinases and endometriosis","volume":"21","author":"Osteen","year":"2003","journal-title":"Semin. Reprod. Med."},{"key":"ref_27","first-page":"3123","article-title":"The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review)","volume":"18","author":"Balkowiec","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bpobgyn.2018.01.011","article-title":"Endometrial stem\/progenitor cells and their role in the pathogenesis of endometriosis","volume":"50","author":"Cousins","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"41679","DOI":"10.18632\/oncotarget.16472","article-title":"Epithelial-to-mesenchymal transition in the development of endometriosis","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/092986711794088416","article-title":"Role of natural killer cell activity in the pathogenesis of endometriosis","volume":"18","author":"Sikora","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/aji.12408","article-title":"Natural Killer Cells: Key Players in Endometriosis","volume":"74","author":"Thiruchelvam","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2916070","DOI":"10.1155\/2016\/2916070","article-title":"Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis","volume":"2016","author":"Jeung","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Chen, Z., Yang, Y., Liu, L.L., and Lundqvist, A. (2019). Strategies to Augment Natural Killer (NK) Cell Activity against Solid Tumors. Cancers, 11.","DOI":"10.3390\/cancers11071040"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Beldi-Ferchiou, A., and Caillat-Zucman, S. (2017). Control of NK Cell Activation by Immune Checkpoint Molecules. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102129"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41423-019-0206-4","article-title":"Human NK cells: Surface receptors, inhibitory checkpoints, and translational applications","volume":"16","author":"Sivori","year":"2019","journal-title":"Cell Mol. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.coi.2004.11.001","article-title":"NK cells in innate immunity","volume":"17","author":"Hamerman","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.immuni.2017.10.008","article-title":"The Broad Spectrum of Human Natural Killer Cell Diversity","volume":"47","author":"Freud","year":"2017","journal-title":"Immunity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood-2005-03-1154","article-title":"Natural-killer cells and dendritic cells: \u201cl\u2019union fait la force\u201d","volume":"106","author":"Walzer","year":"2005","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"18360","DOI":"10.1073\/pnas.1110584108","article-title":"Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells","volume":"108","author":"Nakayama","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fimmu.2014.00027","article-title":"NK cell autoreactivity and autoimmune diseases","volume":"5","author":"Poggi","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/MOT.0b013e32834254cf","article-title":"Natural killer cells in rejection and tolerance of solid organ allografts","volume":"16","author":"Benichou","year":"2011","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_43","first-page":"301","article-title":"Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration","volume":"8","author":"Surette","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fimmu.2017.00467","article-title":"Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice","volume":"8","author":"Gaynor","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.4049\/jimmunol.1502570","article-title":"Human CD56bright NK Cells: An Update","volume":"196","author":"Michel","year":"2016","journal-title":"J. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12026-013-8477-9","article-title":"Organ-specific phenotypic and functional features of NK cells in humans","volume":"58","author":"Sharma","year":"2014","journal-title":"Immunol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3389\/fimmu.2019.01812","article-title":"On the Way to Become a Natural Killer Cell","volume":"10","author":"Mikulak","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Bulmer, J.N., and Lash, G.E. (2019). Uterine natural killer cells: Time for a re-appraisal?. F1000Res., 8.","DOI":"10.12688\/f1000research.19132.1"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2017.03.001","article-title":"Uterine NK cells and macrophages in pregnancy","volume":"56","author":"Faas","year":"2017","journal-title":"Placenta."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/JLB.MR0718-269R","article-title":"Mechanisms of natural killer cell-mediated cellular cytotoxicity","volume":"105","author":"Prager","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ejcb.2010.10.006","article-title":"Insights into the molecular regulation of FasL (CD178) biology","volume":"90","author":"Lettau","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Soboloff, J., and Kappes, D.J. (2018). Natural Killer T (NKT) Cells in Mice and Men. Signaling Mechanisms Regulating T. Cell Diversity and Function, CRC Press\/Taylor & Francis.","DOI":"10.1201\/9781315371689"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/imm.12921","article-title":"Natural killer cell cytotoxicity and its regulation by inhibitory receptors","volume":"154","author":"Kumar","year":"2018","journal-title":"Immunology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.4049\/jimmunol.1601004","article-title":"LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation","volume":"198","author":"Urlaub","year":"2017","journal-title":"J. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3389\/fimmu.2019.01179","article-title":"Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation","volume":"10","author":"Pende","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cll.2018.08.001","article-title":"Diversity of Killer Cell Immunoglobulin-Like Receptors and Disease","volume":"38","author":"Rajalingam","year":"2018","journal-title":"Clin. Lab. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri3370","article-title":"Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution","volume":"13","author":"Parham","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00262-017-2023-x","article-title":"LILRB receptor-mediated regulation of myeloid cell maturation and function","volume":"66","author":"Chen","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fimmu.2016.00281","article-title":"Leukocyte Ig-Like Receptors - A Model for MHC Class I Disease Associations","volume":"7","author":"Hudson","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.it.2013.01.003","article-title":"Activating natural cytotoxicity receptors of natural killer cells in cancer and infection","volume":"34","author":"Koch","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fimmu.2013.00069","article-title":"Natural cytotoxicity receptors: Broader expression patterns and functions in innate and adaptive immune cells","volume":"4","author":"Hudspeth","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2018.00827","article-title":"The NKG2D\/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease","volume":"9","author":"Stojanovic","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fimmu.2018.00476","article-title":"NKG2D and Its Ligands: \u201cOne for All, All for One\u201d","volume":"9","author":"Zingoni","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fimmu.2013.00362","article-title":"Modulation of NK cell function by genetically coupled C-type lectin-like receptor\/ligand pairs encoded in the human natural killer gene complex","volume":"4","author":"Bartel","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fimmu.2014.00214","article-title":"Complexity and Diversity of the NKR-P1: Clr (Klrb1:Clec2) Recognition Systems","volume":"5","author":"Kirkham","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1615\/CritRevImmunol.2019029559","article-title":"Biological and Clinical Significance of Human NKRP1A\/LLT1 Receptor\/Ligand Interactions","volume":"38","author":"Bialoszewska","year":"2018","journal-title":"Crit. Rev. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.molimm.2004.07.030","article-title":"Coordination of activating and inhibitory signals in natural killer cells","volume":"42","author":"Chiesa","year":"2005","journal-title":"Mol. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0015-0282(16)55224-8","article-title":"The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis","volume":"58","author":"Oosterlynck","year":"1992","journal-title":"Fertil. Steril."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0015-0282(16)54414-8","article-title":"Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium","volume":"56","author":"Oosterlynck","year":"1991","journal-title":"Fertil. Steril."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/09513599509160201","article-title":"Natural killer activity in stage III and IV endometriosis: Impaired cytotoxicity and retained lymphokine responsiveness of natural killer cells","volume":"9","author":"Garzetti","year":"1995","journal-title":"Gynecol. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S0015-0282(16)57082-4","article-title":"Decreased natural killer cell activity in endometriosis patients: Relationship to disease pathogenesis","volume":"62","author":"Wilson","year":"1994","journal-title":"Fertil. Steril."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajog.2003.08.032","article-title":"In vitro effect of gonadotropin-releasing hormone agonist on natural killer cell cytolysis in women with and without endometriosis","volume":"190","author":"Wong","year":"2004","journal-title":"Am J Obstet. Gynecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.lfs.2006.01.026","article-title":"Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE","volume":"79","author":"Quaranta","year":"2006","journal-title":"Life Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000292556","article-title":"Lymphokine-activated killer activity in women with endometriosis","volume":"37","author":"Oosterlynck","year":"1994","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1093\/oxfordjournals.humrep.a135765","article-title":"Peritoneal natural killer cytotoxicity and CD25+ CD3+ lymphocyte subpopulation are decreased in women with stage III-IV endometriosis","volume":"10","author":"Ho","year":"1995","journal-title":"Hum. Reprod."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0015-0282(00)01592-2","article-title":"Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis","volume":"74","author":"Wu","year":"2000","journal-title":"Fertil. Steril."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"42","DOI":"10.7150\/ijms.10076","article-title":"Effect of helixor A on natural killer cell activity in endometriosis","volume":"12","author":"Jeung","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000292720","article-title":"Decreased natural killer cell activity in women with endometriosis","volume":"34","author":"Tanaka","year":"1992","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1600-0897.2004.00170.x","article-title":"Killer inhibitory receptor CD158a overexpression among natural killer cells in women with endometriosis is undiminished by laparoscopic surgery and gonadotropin releasing hormone agonist treatment","volume":"51","author":"Maeda","year":"2004","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S0015-0282(16)54661-5","article-title":"Deficient antiendometrium lymphocyte-mediated cytotoxicity in patients with endometriosis","volume":"56","author":"Vigano","year":"1991","journal-title":"Fertil. Steril."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/ijc.2910180405","article-title":"Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia","volume":"18","author":"Klein","year":"1976","journal-title":"Int. J. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1189\/jlb.4AB1014-499R","article-title":"Functional analysis of NK cell subsets activated by 721.221 and K562 HLA-null cells","volume":"97","author":"Lisovsky","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1600-0897.1993.tb00623.x","article-title":"Recombinant interleukin-2 corrects in vitro the immunological defect of endometriosis","volume":"30","author":"Melioli","year":"1993","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0015-0282(01)03249-6","article-title":"Aberrant expression of intercellular adhesion molecule-1 and killer inhibitory receptors induces immune tolerance in women with pelvic endometriosis","volume":"77","author":"Maeda","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0015-0282(03)00552-1","article-title":"Blood leukocyte subsets are modulated in patients with endometriosis","volume":"80","author":"Gagne","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1600-0897.2005.00271.x","article-title":"Expression of inhibitory-motif killer immunoglobulin-like receptor, KIR2DL1, is increased in natural killer cells from women with pelvic endometriosis","volume":"53","author":"Matsuoka","year":"2005","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-0897.2005.00332.x","article-title":"Killer immunoglobulin-like receptor and human leukocyte antigen expression as immunodiagnostic parameters for pelvic endometriosis","volume":"55","author":"Zhang","year":"2006","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.fertnstert.2007.05.018","article-title":"Increased frequency of human leukocyte antigen-E inhibitory receptor CD94\/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis","volume":"89","author":"Galandrini","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/00016349309013364","article-title":"Changes of peripheral blood lymphocyte subsets before and after operation of patients with endometriosis","volume":"72","author":"Kikuchi","year":"1993","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/0962935031000134842","article-title":"The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis","volume":"12","author":"Szyllo","year":"2003","journal-title":"Mediators Inflamm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jmig.2011.12.021","article-title":"Patients with endometriosis of the rectosigmoid have a higher percentage of natural killer cells in peripheral blood","volume":"19","author":"Dias","year":"2012","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0897.1994.tb00843.x","article-title":"Flow cytometry analysis of lymphocyte subpopulations in peritoneal fluid of women with endometriosis","volume":"31","author":"Oosterlynck","year":"1994","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2008.12.005","article-title":"Intraperitoneal immune cell status in infertile women with and without endometriosis","volume":"80","author":"Tariverdian","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/humrep\/deu172","article-title":"An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression","volume":"29","author":"Kang","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0301-2115(95)02222-S","article-title":"Endometrial leukocyte subpopulations in women with endometriosis","volume":"63","author":"Klentzeris","year":"1995","journal-title":"Eur J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/aji.12259","article-title":"Characterization of uterine NK cells in women with infertility or recurrent pregnancy loss and associated endometriosis","volume":"72","author":"Giuliani","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1600-0897.1994.tb01110.x","article-title":"Characterization of lymphocyte subpopulations and T cell activation in endometriosis","volume":"32","author":"Witz","year":"1994","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12958-018-0385-3","article-title":"The dynamic changes in the number of uterine natural killer cells are specific to the eutopic but not to the ectopic endometrium in women and in a baboon model of endometriosis","volume":"16","author":"Drury","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0015-0282(01)02964-8","article-title":"Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis","volume":"77","author":"Maeda","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.fertnstert.2007.12.005","article-title":"Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase","volume":"91","author":"Kawashima","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1111\/j.1600-0854.2010.01112.x","article-title":"Endosomal signaling and a novel pathway defined by the natural killer receptor KIR2DL4 (CD158d)","volume":"11","author":"Rajagopalan","year":"2010","journal-title":"Traffic"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fertnstert.2005.06.057","article-title":"The endometria of patients with endometriosis show higher expression of class I human leukocyte antigen than the endometria of healthy women","volume":"85","author":"Verdu","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1093\/humrep\/13.11.3206","article-title":"Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: Relationship with stage and non-pigmented peritoneal lesions","volume":"13","author":"Alviggi","year":"1998","journal-title":"Hum. Reprod."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/09629350120054545","article-title":"The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with endometriosis after treatment with danazol and leuprorelin acetate depot","volume":"10","author":"Matalliotakis","year":"2001","journal-title":"Mediators Inflamm."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/eji.200737515","article-title":"Immune modulation of HLA-G dimer in maternal-fetal interface","volume":"37","author":"Kuroki","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/imr.12323","article-title":"Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction","volume":"267","author":"Moffett","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/humrep\/deq120","article-title":"Soluble HLA-G is an independent factor for the prediction of pregnancy outcome after ART: A German multi-centre study","volume":"25","author":"Rebmann","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0015-0282(00)01791-X","article-title":"Histocompatibility leukocyte antigen-G is not expressed by endometriosis or endometrial tissue","volume":"75","author":"Hornung","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/humrep\/dei408","article-title":"HLA-G is expressed by the glandular epithelium of peritoneal endometriosis but not in eutopic endometrium","volume":"21","author":"Barrier","year":"2006","journal-title":"Hum. Reprod."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.fertnstert.2007.06.073","article-title":"Human leukocyte antigen-G is expressed by the eutopic and ectopic endometrium of adenomyosis","volume":"90","author":"Wang","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejogrb.2019.01.030","article-title":"HLA-G is upregulated in advanced endometriosis","volume":"235","author":"Rached","year":"2019","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.fertnstert.2007.02.036","article-title":"Soluble HLA-G in the peritoneal fluid of women with endometriosis","volume":"89","author":"Eidukaite","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/smim.2000.0213","article-title":"NK cell recognition of non-classical HLA class I molecules","volume":"12","author":"Llano","year":"2000","journal-title":"Semin. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/humrep\/dew057","article-title":"Platelet-derived TGF-beta1 mediates the down-modulation of NKG2D expression and may be responsible for impaired natural killer (NK) cytotoxicity in women with endometriosis","volume":"31","author":"Guo","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1158\/2326-6066.CIR-15-0098","article-title":"NKG2D Receptor and Its Ligands in Host Defense","volume":"3","author":"Lanier","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Gonzalez-Foruria, I., Santulli, P., Chouzenoux, S., Carmona, F., Batteux, F., and Chapron, C. (2015). Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119961"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4049\/jimmunol.1700387","article-title":"A Role of NKR-P1A (CD161) and Lectin-like Transcript 1 in Natural Cytotoxicity against Human Articular Chondrocytes","volume":"200","author":"Bialoszewska","year":"2018","journal-title":"J. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7041342","DOI":"10.1155\/2018\/7041342","article-title":"The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters","volume":"2018","author":"Walankiewicz","year":"2018","journal-title":"Mediators Inflamm."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/09513590.2018.1519787","article-title":"Expression of programmed death-1 (PD-1) and its ligand PD-L1 is upregulated in endometriosis and promoted by 17beta-estradiol","volume":"35","author":"Wu","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1034\/j.1600-0897.2001.d01-22.x","article-title":"Suppression of natural killer cell function and production of soluble ICAM-1: Endometrial stroma versus melanoma","volume":"46","author":"Vigano","year":"2001","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/oxfordjournals.humrep.a019353","article-title":"Human endometrial stromal cells as a source of soluble intercellular adhesion molecule (ICAM)-1 molecules","volume":"11","author":"Somigliana","year":"1996","journal-title":"Hum. Reprod."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000052854","article-title":"Intercellular adhesion molecule-1 and hepatocyte growth factor in human endometriosis: Original investigation and a review of literature","volume":"47","author":"Fukaya","year":"1999","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s00018-019-03056-x","article-title":"Anti-inflammatory cytokines in endometriosis","volume":"76","author":"Zhou","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"ref_124","first-page":"206","article-title":"Immunosuppressive activity of peritoneal fluid in women with endometriosis","volume":"82","author":"Oosterlynck","year":"1993","journal-title":"Obstet. Gynecol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1600-0897.1996.tb00179.x","article-title":"Modulation of NK cell lytic function by endometrial secretory factors: Potential role in endometriosis","volume":"36","author":"Somigliana","year":"1996","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0002-9378(11)91670-6","article-title":"Suppression of natural killer cell activity by sera from patients with endometriosis","volume":"167","author":"Kanzaki","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000292519","article-title":"Endometriotic tissues produce immunosuppressive factors","volume":"37","author":"Hirata","year":"1994","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.imlet.2018.10.011","article-title":"The involvement of multifunctional TGF-beta and related cytokines in pathogenesis of endometriosis","volume":"201","author":"Sikora","year":"2018","journal-title":"Immunol. Lett."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Bellelis, P., Frediani Barbeiro, D., Gueuvoghlanian-Silva, B.Y., Kalil, J., Abrao, M.S., and Podgaec, S. (2019). Interleukin-15 and Interleukin-7 are the Major Cytokines to Maintain Endometriosis. Gynecol. Obstet. Investig., 1\u201310.","DOI":"10.1159\/000496607"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1530\/REP-16-0089","article-title":"IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis","volume":"152","author":"Yu","year":"2016","journal-title":"Reproduction"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.4049\/jimmunol.143.4.1206","article-title":"IFN-beta 2\/IL-6 augments the activity of human natural killer cells","volume":"143","author":"Luger","year":"1989","journal-title":"J. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0008-8749(91)90390-W","article-title":"Constitutive release of IL6 by human papillomavirus type 16 (HPV16)-harboring keratinocytes: A mechanism augmenting the NK-cell-mediated lysis of HPV-bearing neoplastic cells","volume":"136","author":"Malejczyk","year":"1991","journal-title":"Cell Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1172\/JCI90387","article-title":"CD56bright NK cells exhibit potent antitumor responses following IL-15 priming","volume":"127","author":"Wagner","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.imlet.2017.08.010","article-title":"The potential and promise of IL-15 in immuno-oncogenic therapies","volume":"190","author":"Robinson","year":"2017","journal-title":"Immunol. Lett."},{"key":"ref_135","first-page":"911","article-title":"Interleukin-12 and its free p40 subunit regulate immune recognition of endometrial cells: Potential role in endometriosis","volume":"83","author":"Mazzeo","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cyto.2019.02.001","article-title":"The role of cytokines in the regulation of NK cells in the tumor environment","volume":"117","author":"Konjevic","year":"2019","journal-title":"Cytokine"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.smim.2008.06.003","article-title":"The Yin and Yang of HLA and KIR in human disease","volume":"20","author":"Kulkarni","year":"2008","journal-title":"Semin. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/imr.12316","article-title":"Human KIR repertoires: Shaped by genetic diversity and evolution","volume":"267","author":"Manser","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1600-0897.2007.00533.x","article-title":"Association of killer cell immunoglobulin-like receptor genotypes with susceptibility to endometriosis","volume":"58","author":"Kitawaki","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Nowak, I., Majorczyk, E., Wisniewski, A., Pawlik, A., Magott-Procelewska, M., Passowicz-Muszynska, E., Malejczyk, J., Ploski, R., Giebel, S., and Barcz, E. (2010). Does the KIR2DS5 gene protect from some human diseases?. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012381"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00251-015-0828-3","article-title":"KIR2DS5 in the presence of HLA-C C2 protects against endometriosis","volume":"67","author":"Nowak","year":"2015","journal-title":"Immunogenetics"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00438-017-1404-3","article-title":"The impact of HLA-G, LILRB1 and LILRB2 gene polymorphisms on susceptibility to and severity of endometriosis","volume":"293","author":"Bylinska","year":"2018","journal-title":"Mol. Genet. Genom."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0198-8859(02)00438-X","article-title":"Association of HLA class I and class II alleles with susceptibility to endometriosis","volume":"63","author":"Kitawaki","year":"2002","journal-title":"Hum. Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/00016348409156977","article-title":"Distribution of HLA-antigens among patients with endometriosis","volume":"123","author":"Moen","year":"1984","journal-title":"Acta. Obstet. Gynecol. Scand. Suppl."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0002-9378(84)90714-2","article-title":"HLA associations in endometriosis","volume":"148","author":"Simpson","year":"1984","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Memon, H., and Patel, B.M. (2019). Immune checkpoint inhibitors in non-small cell lung cancer: A bird\u2019s eye view. Life Sci., 116713.","DOI":"10.1016\/j.lfs.2019.116713"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Giannopoulos, K. (2019). Targeting Immune Signaling Checkpoints in Acute Myeloid Leukemia. J. Clin. Med., 8.","DOI":"10.3390\/jcm8020236"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0171-2985(86)80122-X","article-title":"Results of clinical trials with the administration of interleukin 2 and adoptive immunotherapy with activated cells in patients with cancer","volume":"172","author":"Lotze","year":"1986","journal-title":"Immunobiology"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jri.2006.12.001","article-title":"Intraperitoneal recombinant interleukin-2 activates leukocytes in rat endometriosis","volume":"74","author":"Velasco","year":"2007","journal-title":"J. Reprod. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Afolabi, L.O., Adeshakin, A.O., Sani, M.M., Bi, J., and Wan, X. (2019). Genetic Reprogramming For NK cell Cancer Immunotherapy with CRISPR\/Cas9. Immunology.","DOI":"10.1111\/imm.13094"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"105695","DOI":"10.1016\/j.intimp.2019.105695","article-title":"Chimeric antigen receptor (CAR)-modified NK cells against cancer: Opportunities and challenges","volume":"74","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000495771","article-title":"CAR-Expressing Natural Killer Cells for Cancer Retargeting","volume":"46","author":"Kloess","year":"2019","journal-title":"Transfus. Med. Hemother."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejca.2016.02.025","article-title":"Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy","volume":"60","author":"Hofmann","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1758835918764628","DOI":"10.1177\/1758835918764628","article-title":"Clinical assessment of immune-related adverse events","volume":"10","author":"Sosa","year":"2018","journal-title":"Ther. Adv. Med. Oncol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/9\/1468\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:15Z","timestamp":1760188815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/9\/1468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,14]]},"references-count":154,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["jcm8091468"],"URL":"https:\/\/doi.org\/10.3390\/jcm8091468","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,14]]}}}