{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:15:57Z","timestamp":1790504157742,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The improvements in dialysis have not eliminated long-term problems, including dialysis-related amyloidosis (DRA), caused by Beta-2 microglobulin deposition. Several types of scintigraphy have been tested to detect DRA, none entered the clinical practice. Aim of the study was to assess the potential of PET-FDG scan in the diagnosis of DRA. Methods: Forty-six dialysis patients with at least one PET scan (72 scans) were selected out 162 patients treated in 2016\u20132018. Subjective global assessment (SGA), malnutrition inflammation score (A), Charlson Comorbidity Index (CCI), were assessed at time of scan; 218 age-matched cases with normal kidney function were selected as controls. PET scans were read in duplicate. Carpal tunnel syndrome was considered a proxy for DRA. A composite \u201camyloid score\u201d score considered each dialysis year = 1 point; carpal tunnel-DRA = 5 points per site. Logistic regression, ROC curves and a prediction model were built. Results: The prevalence of positive PET was 43.5% in dialysis, 5% in controls (p &lt; 0.0001). PET was positive in 14\/15 (93.3%) scans in patients with carpal tunnel. PET sensitivity for detecting DRA was 95% (specificity 64%). Carpal tunnel was related to dialysis vintage and MIS. A positive PET scan was significantly associated with dialysis vintage, MIS and amyloid score. A prediction model to explain PET positivity combined clinical score and MIS, allowing for an AUC of 0.906 (CI: 0.813\u20130.962; p &lt; 0.001). Conclusions: PET-FDG may identify DRA, and may be useful in detecting cases in which inflammation favours B2M deposition. This finding, needing large-scale confirmation, could open new perspectives in the study of DRA.<\/jats:p>","DOI":"10.3390\/jcm8091494","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T10:55:21Z","timestamp":1568890521000},"page":"1494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Positron Emission Tomography Can Support the Diagnosis of Dialysis-Related Amyloidosis"],"prefix":"10.3390","volume":"8","author":[{"given":"Giulia","family":"Santagati","sequence":"first","affiliation":[{"name":"N\u00e9phrologie, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Cataldo","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Columbano","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-180X","authenticated-orcid":false,"given":"Antoine","family":"Chatrenet","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-1838","authenticated-orcid":false,"given":"Daniele","family":"Penna","sequence":"additional","affiliation":[{"name":"Affidea IRMET, PET CENTER, Torino via Onorato Vigliani 89, 10135 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-4047","authenticated-orcid":false,"given":"Ettore","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Affidea IRMET, PET CENTER, Torino via Onorato Vigliani 89, 10135 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mammar","family":"Hachemi","sequence":"additional","affiliation":[{"name":"Medecine Nucleaire, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lurlinys","family":"Gendrot","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Nielsen","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cinquantini","sequence":"additional","affiliation":[{"name":"Radiology, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Saulnier","sequence":"additional","affiliation":[{"name":"MINT Universit\u00e9 d\u2019Angers, 49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Arena","sequence":"additional","affiliation":[{"name":"Affidea IRMET, PET CENTER, Torino via Onorato Vigliani 89, 10135 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Boursot","sequence":"additional","affiliation":[{"name":"Medecine Nucleaire, Centre Hospitalier du Mans, 72037 Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2632-4009","authenticated-orcid":false,"given":"Giorgina Barbara","family":"Piccoli","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie, Centre Hospitalier du Mans, 72037 Le Mans, France"},{"name":"Dipartimento di Scienze Cliniche e Biologiche, Universit\u00e0 di Torino, 10100 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0272-6386(96)90397-2","article-title":"An observational study of cardiovascular characteristics of long-term end-stage renal disease survivors","volume":"28","author":"Owen","year":"1996","journal-title":"Am. 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