{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:10Z","timestamp":1787028670596,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Oral health issues are commonly reported in systemic sclerosis (SSc), comprising a broad spectrum of manifestations, e.g., reduced mouth opening, periodontal disease, increased periodontal ligament (PDL) space width, and mandibular resorption. We aimed to assess oral radiographic abnormalities, particularly PDL space widening and erosions, and to identify potential relations with disease measures. Methods: cross-sectional study in 43 SSc and matching controls receiving systematic oral assessments (full mouth dental\/periodontal) and imaging (radiographs and cone beam computed tomography (CBCT)). Associations between disease variables and radiologic findings were investigated by univariate and multivariate analysis (SPSS-v.20, p &lt; 0.05). Results: CBCT demonstrated generalized PDL space widening in up to half SSc, with at least one tooth involved, essentially in the posterior region (p &lt; 0.05). Significant correlations between number of teeth with PDL space widening and disease severity, skin score, disease subset, topoisomerase I specificity, age, and disease duration were reported (p &lt; 0.05). Additionally, mandibular erosions were described in one out of four patients, commonly condylar erosions. Conclusions: Tridimensional CBCT approach confirmed widening of PDL and mandibular erosions as common dental findings in scleroderma. Furthermore, widened PDL spaces correlated with several disease characteristics including severity, skin extent, and antibody profile.<\/jats:p>","DOI":"10.3390\/jcm8101620","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T10:54:58Z","timestamp":1570186498000},"page":"1620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Volumetric Cone Beam Computed Tomography for the Assessment of Oral Manifestations in Systemic Sclerosis: Data from an EUSTAR Cohort"],"prefix":"10.3390","volume":"8","author":[{"given":"Cristina","family":"Iordache","sequence":"first","affiliation":[{"name":"Department of Implantology, Removable Dentures, Technology, Ergonomics Discipline, School of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Ia\u0219i, Iasi 700115, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda-Ecaterina","family":"Antohe","sequence":"additional","affiliation":[{"name":"Department of Implantology, Removable Dentures, Technology, Removable Denture Discipline, School of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Ia\u0219i, Iasi 700115, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodica","family":"Chirieac","sequence":"additional","affiliation":[{"name":"Sancare Medical and Research Center, Iasi 700503, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Ancu\u021ba","sequence":"additional","affiliation":[{"name":"Elena Doamna Clinical Hospital, Research Department, Iasi 700398, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"\u021a\u0103nculescu","sequence":"additional","affiliation":[{"name":"Department of Odontology-Periodontology, Fixed Prosthodontics, School of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codrina","family":"Ancu\u021ba","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, School of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.mayocp.2013.01.018","article-title":"My approach to the treatment of scleroderma","volume":"88","author":"Shah","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"ref_2","first-page":"4569826","article-title":"Systemic Sclerosis Pathogenesis and Emerging Therapies, beyond the Fibroblast","volume":"2019","year":"2019","journal-title":"BioMed Res. 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