{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:43:37Z","timestamp":1771659817257,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA &lt;2000 IU\/mL and ALT &lt;40 U\/L); grey zone group 1 (GZ-1; HBV DNA &lt;2000 IU\/mL and ALT &gt;40 U\/L); grey zone group 2 (GZ-2; HBV-DNA &gt;2000 IU\/mL and ALT &lt;40 U\/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p &lt; 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.<\/jats:p>","DOI":"10.3390\/jcm8122101","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:50:45Z","timestamp":1575283845000},"page":"2101","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection"],"prefix":"10.3390","volume":"8","author":[{"given":"Christiana","family":"Graf","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Mondorf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viola","family":"Knop","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Henrik","family":"Peiffer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Dietz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Friess","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany"},{"name":"Department of Gastroenterology and Hepatology, University Hospital Essen, 45147 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Buggisch","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Medicine IFI, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Mauss","sequence":"additional","affiliation":[{"name":"Center for HIV and Hepatogastroenterology, 40237 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-6241","authenticated-orcid":false,"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, University Hospital Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rausch","sequence":"additional","affiliation":[{"name":"Practice of Internal Medicine, 10777 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sprinzl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-6786","authenticated-orcid":false,"given":"Hartwig","family":"Klinker","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Division of Hepatology, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hinrichsen","sequence":"additional","affiliation":[{"name":"Gastroenterology-Hepatology Center, 24105 Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Bronowicki","sequence":"additional","affiliation":[{"name":"Hepato-Gastroenterology, Hopital Brabois- CHU Nancy, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Haag","sequence":"additional","affiliation":[{"name":"Practice of Gastroenterology, 65189 Wiesbaden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"H\u00fcppe","sequence":"additional","affiliation":[{"name":"Practice of Hepatology, 44623 Herne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lutz","sequence":"additional","affiliation":[{"name":"Infektiologikum, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Poynard","sequence":"additional","affiliation":[{"name":"BioPredictive, 75007 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireen","family":"Friedrich-Rust","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Sarrazin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"},{"name":"Department of Gastroenterology, St. Josefs-Hospital, 65189 Wiesbaden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Vermehren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1056\/NEJMra0801644","article-title":"Hepatitis B Virus Infection","volume":"359","author":"Dienstag","year":"2008","journal-title":"N. 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