{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:09:19Z","timestamp":1769270959629,"version":"3.49.0"},"reference-count":28,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: A lesion within the dentato-rubro-olivary pathway (DROP) in the posterior fossa can cause secondary neurodegeneration of the inferior olivary nucleus: so-called hypertrophic olivary degeneration (HOD). The clinical syndrome of HOD occurs slowly over months and may be overlooked in progressive neuro-oncological diseases. Posterior fossa tumors are often located near these strategic structures. The goal of this study was to analyze the systematics of HOD occurrence in neuro-oncological patients. (2) Methods: The neuroradiological database of the university healthcare center was scanned for HOD-related terms from 2010 to 2019. After excluding patients with other causes of HOD, 12 datasets from neuro-oncological patients were analyzed under predetermined criteria. (3) Results: Patients received multimodal tumor treatments including neurosurgery, radiotherapy, and chemotherapy. HOD occurred both unilaterally (left n = 4; right n = 5) and bilaterally (n = 3). Though the mass effect of posterior fossa tumors had already affected strategic structures of the DROP, none of the patients showed signs of HOD on MRI until therapeutic measures including neurosurgery affecting the DROP were applied. HOD was visible on MRI within a median of 6 months after the neurosurgical intervention. In 67%, the presumed underlying surgical lesion in the DROP lay in the contralateral dentate nucleus. (4) Conclusion: In a selected cohort of neuro-oncological patients, therapeutic lesions within the DROP were associated with HOD occurrence.<\/jats:p>","DOI":"10.3390\/jcm8122222","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T02:59:01Z","timestamp":1576551541000},"page":"2222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-9908","authenticated-orcid":false,"given":"Martin A.","family":"Schaller-Paule","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Foerch","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Kluge","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2563-2691","authenticated-orcid":false,"given":"Peter","family":"Baumgarten","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Konczalla","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim P.","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"},{"name":"University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, 60528 Frankfurt am Main, Germany"},{"name":"Frankfurt Cancer Institute (FCI), University Hospital Frankfurt, Goethe-University, 60596 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-3694","authenticated-orcid":false,"given":"Anna-Luisa","family":"Luger","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"},{"name":"University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe-University, 60528 Frankfurt am Main, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, 60528 Frankfurt am Main, Germany"},{"name":"Frankfurt Cancer Institute (FCI), University Hospital Frankfurt, Goethe-University, 60596 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00697000","article-title":"Olivary enlargement: Chronological and morphometric analyses","volume":"54","author":"Goto","year":"1981","journal-title":"Acta Neuropathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00314146","article-title":"Rhythmic palatal myoclonus and the dentato-olivary pathway","volume":"220","author":"Lapresle","year":"1979","journal-title":"J. Neurol."},{"key":"ref_3","first-page":"48","article-title":"Sur la d\u00e9g\u00e9n\u00e9ration pseudo-hypertrophique de l\u2019olive bulbaire","volume":"26","author":"Marie","year":"1913","journal-title":"Rev. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2019.04.024","article-title":"Hypertrophic olivary degeneration: A comprehensive review focusing on etiology","volume":"1718","author":"Wang","year":"2019","journal-title":"Brain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e763","DOI":"10.1016\/j.wneu.2018.01.150","article-title":"Hypertrophic Olivary Degeneration: Neurosurgical Perspective and Literature Review","volume":"112","author":"Onen","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1148\/radiology.192.2.8029428","article-title":"Hypertrophic olivary degeneration: MR imaging and pathologic findings","volume":"192","author":"Kitajima","year":"1994","journal-title":"Radiology"},{"key":"ref_7","first-page":"1073","article-title":"Hypertrophic olivary degeneration: Metaanalysis of the temporal evolution of MR findings","volume":"21","author":"Goyal","year":"2000","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/brain\/84.3.341","article-title":"Enlargement of the inferior olivary nucleus in association with lesions of the central tegmental tract or dentate nucleus","volume":"84","author":"Gautier","year":"1961","journal-title":"Brain"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/practneurol-2015-001142","article-title":"The Guillain-Mollaret triangle in action","volume":"16","author":"Murdoch","year":"2016","journal-title":"Pract. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fneur.2017.00302","article-title":"Hypertrophic Olivary Degeneration and Palatal or Oculopalatal Tremor","volume":"8","author":"Tilikete","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/jon.12118","article-title":"Frequency of bilateral hypertrophic olivary degeneration in a large retrospective cohort","volume":"25","author":"Carr","year":"2015","journal-title":"J. Neuroimaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00415-011-6170-2","article-title":"Vertical pendular nystagmus and hypertrophic inferior olivary nuclei degeneration: An \u201codd couple\u201d","volume":"259","author":"Carota","year":"2012","journal-title":"J. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1055\/s-0038-1628538","article-title":"Hypertrophe Degeneration des Nucleus olivaris","volume":"32","author":"Graf","year":"2013","journal-title":"Nervenheilkunde"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00115-018-0646-6","article-title":"Hypertrophe Degeneration der Olive: Ursache neuerlicher neurologischer Symptome nach Schlaganfall","volume":"90","author":"Foerch","year":"2019","journal-title":"Nervenarzt"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.clinimag.2015.05.015","article-title":"Hypertrophic olivary degeneration resulting from posterior fossa masses and their treatments","volume":"39","author":"Hirano","year":"2015","journal-title":"Clin. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00314408","article-title":"MRI findings of inferior olives in palatal myoclonus","volume":"236","author":"Yokota","year":"1989","journal-title":"J. Neurol."},{"key":"ref_17","first-page":"401","article-title":"MRI and MR tractography in bilateral hypertrophic olivary degeneration. Indian","volume":"24","author":"Sen","year":"2014","journal-title":"J. Radiol. Imaging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/2156-7514.150454","article-title":"Hypertrophic olivary degeneration\u2014A report of two cases","volume":"5","author":"Sarawagi","year":"2015","journal-title":"J. Clin. Imaging Sci."},{"key":"ref_19","first-page":"545","article-title":"Deux cas de myoclonies synchrones et rythm\u00e9es v\u00e9lo-pharyngo-laryngo-oculo-diaphragmatiques: Le probl\u00e8me anatomique et physiologique","volume":"2","author":"Guillain","year":"1931","journal-title":"Rev. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1001\/archneur.65.9.1248","article-title":"Progressive ataxia and palatal tremor","volume":"65","author":"Brinar","year":"2008","journal-title":"Arch. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/brain\/awh137","article-title":"Progressive ataxia and palatal tremor (PAPT): Clinical and MRI assessment with review of palatal tremors","volume":"127","author":"Samuel","year":"2004","journal-title":"Brain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00701-012-1567-y","article-title":"Hypertrophic olivary degeneration following surgical resection or gamma knife radiosurgery of brainstem cavernous malformations: An 11-case series and a review of literature","volume":"155","author":"Yun","year":"2013","journal-title":"Acta Neurochir."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2463\/mrms.11.299","article-title":"Hypertrophic olivary degeneration after gamma-knife radiosurgery for pontine metastasis","volume":"11","author":"Shinohara","year":"2012","journal-title":"Magn. Reson. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/mds.10224","article-title":"Levodopa-responsive rubral (Holmes\u2019) tremor","volume":"17","author":"Cosentino","year":"2002","journal-title":"Mov. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/mds.870020202","article-title":"Effectiveness of trihexyphenidyl against pendular nystagmus and palatal myoclonus: Evidence of cholinergic dysfunction","volume":"2","author":"Jabbari","year":"1987","journal-title":"Mov. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1212\/WNL.0000000000002440","article-title":"Holmes tremor: Clinical description, lesion localization, and treatment in a series of 29 cases","volume":"86","author":"Raina","year":"2016","journal-title":"Neurology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1474-4422(10)70322-7","article-title":"Treatment of patients with essential tremor","volume":"10","author":"Deuschl","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.parkreldis.2008.01.020","article-title":"Failed DBS for palliation of visual problems in a case of oculopalatal tremor","volume":"15","author":"Wang","year":"2009","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/12\/2222\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:42:41Z","timestamp":1760190161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/12\/2222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["jcm8122222"],"URL":"https:\/\/doi.org\/10.3390\/jcm8122222","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,16]]}}}