{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:21:23Z","timestamp":1777580483471,"version":"3.51.4"},"reference-count":103,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility.<\/jats:p>","DOI":"10.3390\/jcm9010113","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T07:40:55Z","timestamp":1577778055000},"page":"113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tachykinins and Kisspeptins in the Regulation of Human Male Fertility"],"prefix":"10.3390","volume":"9","author":[{"given":"V\u00edctor","family":"Blasco","sequence":"first","affiliation":[{"name":"IVI-RMA Seville, Avda. Rep\u00fablica Argentina 58, ES-41011 Seville, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe), ES-46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco M.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmicas, CSIC, Avenida Americo Vespucio 49, ES-41092 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gonz\u00e1lez-Ravina","sequence":"additional","affiliation":[{"name":"IVI-RMA Seville, Avda. Rep\u00fablica Argentina 58, ES-41011 Seville, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe), ES-46026 Valencia, Spain"},{"name":"Departamento de Biolog\u00eda Molecular e Ingenier\u00eda Bioqu\u00edmica, Universidad Pablo de Olavide, ES-41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-9116","authenticated-orcid":false,"given":"Esther","family":"Santamar\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"IVI-RMA Seville, Avda. Rep\u00fablica Argentina 58, ES-41011 Seville, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe), ES-46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Candenas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Qu\u00edmicas, CSIC, Avenida Americo Vespucio 49, ES-41092 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-2984","authenticated-orcid":false,"given":"Manuel","family":"Fern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"IVI-RMA Seville, Avda. Rep\u00fablica Argentina 58, ES-41011 Seville, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe), ES-46026 Valencia, Spain"},{"name":"Departamento de Biolog\u00eda Molecular e Ingenier\u00eda Bioqu\u00edmica, Universidad Pablo de Olavide, ES-41013 Seville, Spain"},{"name":"Departamento de Cirug\u00eda, Universidad de Sevilla, Avda. S\u00e1nchez Pizjuan S\/N, ES-41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Majzoub, A., Parekh, N., and Henkel, R. (2019). A Schematic Overview of the Current Status of Male Infertility Practice. World J. 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