{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:20Z","timestamp":1792789520512,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Rd16\/0025\/0019; PT17\/15\/42; PI16\/01863; CIBER-BBN"],"award-info":[{"award-number":["Rd16\/0025\/0019; PT17\/15\/42; PI16\/01863; CIBER-BBN"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PENTA FOUNDATION","award":["EPIICAL PROJECT"],"award-info":[{"award-number":["EPIICAL PROJECT"]}]},{"DOI":"10.13039\/501100005643","name":"Uniwersytet \u0141\u00f3dzki","doi-asserted-by":"publisher","award":["NAWA International Academic Partnership Programme"],"award-info":[{"award-number":["NAWA International Academic Partnership Programme"]}],"id":[{"id":"10.13039\/501100005643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["COST Action CA 17140 \"Cancer Nanomedicine from the Bench to the Bedside\""],"award-info":[{"award-number":["COST Action CA 17140 \"Cancer Nanomedicine from the Bench to the Bedside\""]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Infections caused by HSV-1 and their typical outbreaks invading the nervous system have been related to neurodegenerative diseases. HSV-1 infection may deregulate the balance between the amyloidogenic and non-amyloidogenic pathways, raising the accumulation of amyloid-\u03b2 peptides, one of the hallmarks in the neurodegenerative diseases. An effective treatment against both, HSV-1 infections and neurodegeneration, is a major therapeutic target. Therefore, gold nanoparticles (NPAus) have been previously studied in immunotherapy, cancer and cellular disruptions with very promising results. Our study demonstrates that a new NPAus family inhibits the HSV-1 infection in a neural-derived SK-N-MC cell line model and that this new NPAus reduces the HSV-1-induced \u03b2-secretase activity, as well as amyloid-\u03b2 accumulation in SK-APP-D1 modifies cell line. We demonstrated that NPAuG3-S8 crosses the blood-brain barrier (BBB) and does not generate cerebral damage to in vivo CD1 mice model. The NPAuG3-S8 could be a promising treatment against neuronal HSV-1 infections and neuronal disorders related to the A\u03b2 peptides.<\/jats:p>","DOI":"10.3390\/jcm9010155","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T03:59:57Z","timestamp":1578455997000},"page":"155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Gold Nanoparticles Crossing Blood-Brain Barrier Prevent HSV-1 Infection and Reduce Herpes Associated Amyloid-\u03b2secretion"],"prefix":"10.3390","volume":"9","author":[{"given":"Rodriguez-Izquierdo","family":"I","sequence":"first","affiliation":[{"name":"Head Immunology Section. Laboratorio InmunoBiolog\u00eda Molecular, Hospital General Universitario Gregorio Mara\u00f1\u00f3n (HGUGM), 28007 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), 28007 Madrid, Spain"},{"name":"Spanish HIV-HGM BioBank, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serramia","family":"MJ","sequence":"additional","affiliation":[{"name":"Head Immunology Section. Laboratorio InmunoBiolog\u00eda Molecular, Hospital General Universitario Gregorio Mara\u00f1\u00f3n (HGUGM), 28007 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), 28007 Madrid, Spain"},{"name":"Spanish HIV-HGM BioBank, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gomez","family":"R","sequence":"additional","affiliation":[{"name":"Departamento Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, Instituto de Investigaci\u00f3n Qu\u00edmica \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR), Universidad de Alcal\u00e1 (UAH), 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De La Mata","family":"FJ","sequence":"additional","affiliation":[{"name":"Departamento Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, Instituto de Investigaci\u00f3n Qu\u00edmica \u201cAndr\u00e9s M. del R\u00edo\u201d (IQAR), Universidad de Alcal\u00e1 (UAH), 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-1117","authenticated-orcid":false,"given":"Bullido","family":"MJ","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa (CSIC-UAM), Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0813-4500","authenticated-orcid":false,"given":"Mu\u00f1oz-Fern\u00e1ndez","family":"MA","sequence":"additional","affiliation":[{"name":"Head Immunology Section. Laboratorio InmunoBiolog\u00eda Molecular, Hospital General Universitario Gregorio Mara\u00f1\u00f3n (HGUGM), 28007 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), 28007 Madrid, Spain"},{"name":"Spanish HIV-HGM BioBank, 28007 Madrid, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1099\/vir.0.000128","article-title":"A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation","volume":"96","author":"Kennedy","year":"2015","journal-title":"J. Gen. 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