{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:04:05Z","timestamp":1783775045962,"version":"3.55.0"},"reference-count":15,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: We performed this prospective double-blind randomized controlled trial to identify the effect of a preoperative prophylactic transdermal scopolamine (TDS) patch on postoperative nausea and vomiting (PONV) after retromastoid craniectomy with microvascular decompression (RMC-MVD). Methods: We recruited 38 patients undergoing RMC-MVD and randomized them into two groups: the TDS group (n = 19, application of the TDS patch) and placebo group (n = 19, application of a sham patch). Nausea (as a self-reported 100-mm visual analog scale (VAS) score; range, 0 (no nausea) to 10 (worst nausea)), vomiting, and the use of antiemetics were the primary endpoints. Results: There was no significant difference in terms of the incidence of PONV (73.7% in the TDS group and 78.9% in the placebo group; p = 1.00) between the groups. However, the mean nausea VAS score was significantly different at arrival to the general ward (0.93 \u00b1 1.71 in the TDS group vs. 2.52 \u00b1 2.85 in the placebo group; p = 0.046), and throughout the study period (0.03 \u00b1 0.07 in the TDS group vs. 0.44 \u00b1 0.71 in the placebo group; p = 0.029). Rescue antiemetics were more frequently used in the placebo group than in the TDS group (9 (47.4%) vs. 2 (10.5%), respectively; p = 0.029). The mean number of antiemetics used throughout the study period was significantly higher in the placebo group than in the TDS group (1.37 \u00b1 2.19 vs. 0.16 \u00b1 0.50, respectively; p = 0.029). Conclusions: The preoperative prophylactic use of a TDS patch was safe and effective in the management of PONV after RMC-MVD in terms of the severity of PONV and the use of rescue antiemetics.<\/jats:p>","DOI":"10.3390\/jcm9010156","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T03:59:57Z","timestamp":1578455997000},"page":"156","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Effect of a Transdermal Scopolamine Patch on Postoperative Nausea and Vomiting after Retromastoid Craniectomy with Microvascular Decompression: A Preliminary Single Center, Double-Blind, Randomized Controlled Trial"],"prefix":"10.3390","volume":"9","author":[{"given":"Hyun Hee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Nursing, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nursing, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Tae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sheikh Khalifa Specialty Hospital, Ras al-Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-729X","authenticated-orcid":false,"given":"Kihwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Korea"},{"name":"Department of Neurosurgery, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Korea"},{"name":"Department of Neurosurgery, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fmed.2015.00040","article-title":"Triple Therapy with Scopolamine, Ondansetron, and Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Moderate to High-Risk Patients Undergoing Craniotomy Under General Anesthesia: A Pilot Study","volume":"2","author":"Bergese","year":"2015","journal-title":"Front. 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