{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:33:13Z","timestamp":1764174793861,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008359","name":"Maag Lever Darm Stichting","doi-asserted-by":"publisher","award":["FP 14-04"],"award-info":[{"award-number":["FP 14-04"]}],"id":[{"id":"10.13039\/501100008359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Hodgkin lymphoma (HL) survivors have an increased colorectal cancer (CRC) risk. Diagnostic accuracy of quantitative fecal immunochemical testing (FIT, OC Sensor) and\/or a multi-target stool DNA test (mt-sDNA, Cologuard\u00ae) for advanced neoplasia (AN) was evaluated. Methods: 101 HL survivors underwent a surveillance colonoscopy and were asked to perform two stool tests (FIT and mt-sDNA). Advanced adenoma (AA), advanced serrated lesion (ASL), and AN (AA, ASL, CRC) were evaluated. Sensitivity, specificity, and area under the curve (AUC) for AN were calculated for different FIT cut-offs and mt-sDNA with colonoscopy as reference. Results: FIT and mt-sDNA were analyzed in 73 (72%) and 82 (81%) participants, respectively. AN was detected in 19 (26%) and 22 (27%), respectively. AN sensitivities for FIT cut-off of 10 ug Hb\/g feces (FIT10) and mt-sDNA were 37% (95% confidence interval (CI): 16\u201362) and 68% (95% CI: 45\u201386), with corresponding specificities of 91% (95% CI: 80\u201397) and 70% (95% CI: 57\u201386), respectively. AUC for FIT was 0.68 (95% CI: 0.54\u20130.82) and for mt-sDNA 0.76 (95% CI: 0.63\u20130.89). Conclusions: In HL survivors, mt-sDNA showed highest sensitivity but with relatively low specificity for AN. Cost-effectiveness analyses is necessary to determine the optimal surveillance strategy.<\/jats:p>","DOI":"10.3390\/jcm9010190","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T10:20:29Z","timestamp":1578651629000},"page":"190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Accuracy of Stool Tests for Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors"],"prefix":"10.3390","volume":"9","author":[{"given":"Berbel","family":"Ykema","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisanne","family":"Rigter","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Spaander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Moons","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Bisseling","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthe","family":"Aleman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-6128","authenticated-orcid":false,"given":"Jan Paul","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieternella","family":"Lugtenburg","sequence":"additional","affiliation":[{"name":"Department of Hematology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Janus","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eefke","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Roesink","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Raemaekers","sequence":"additional","affiliation":[{"name":"Department of Hematology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"van der Maazen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Lansdorp-Vogelaar","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC, 3015 GD Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gini","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC, 3015 GD Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wieke","family":"Verbeek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margriet","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petur","family":"Snaebjornsson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"van Leerdam","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1200\/JCO.2006.09.0936","article-title":"Long-Term Solid Cancer Risk Among 5-Year Survivors of Hodgkin\u2019s Lymphoma","volume":"25","author":"Hodgson","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1505949","article-title":"Second Cancer Risk Up to 40 Years after Treatment for Hodgkin\u2019s Lymphoma","volume":"373","author":"Schaapveld","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1200\/JCO.2011.34.8268","article-title":"Second Cancer Risk After Chemotherapy for Hodgkin\u2019s Lymphoma: A Collaborative British Cohort Study","volume":"29","author":"Swerdlow","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1200\/JCO.2011.37.8760","article-title":"Secondary Colorectal Carcinoma After Childhood Cancer","volume":"30","author":"Nottage","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/bjc.2017.177","article-title":"Infradiaphragmatic irradiation and high procarbazine doses increase colorectal cancer risk in Hodgkin lymphoma survivors","volume":"117","author":"Schaapveld","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.7326\/0003-4819-156-11-201206050-00002","article-title":"Secondary gastrointestinal cancer in childhood cancer survivors: A cohort study","volume":"156","author":"Henderson","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/cncr.31903","article-title":"High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors","volume":"125","author":"Rigter","year":"2019","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1016\/j.cgh.2019.09.007","article-title":"Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis","volume":"17","author":"Roos","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/S0140-6736(12)62186-2","article-title":"Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): A multicentre randomised trial","volume":"381","author":"Atkin","year":"2013","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1148\/radiol.12111523","article-title":"Patient Acceptability and Psychologic Consequences of CT Colonography Compared with Those of Colonoscopy: Results from a Multicenter Randomized Controlled Trial of Symptomatic Patients","volume":"263","author":"Ghanouni","year":"2012","journal-title":"Radiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3748\/wjg.v25.i2.190","article-title":"Adverse events related to colonoscopy: Global trends and future challenges","volume":"25","author":"Kim","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa1100370","article-title":"Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths","volume":"366","author":"Zauber","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1301969","article-title":"Long-term colorectal-cancer incidence and mortality after lower endoscopy","volume":"369","author":"Nishihara","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/gut.48.6.812","article-title":"Efficacy in standard clinical practice of colonoscopic polypectomy in reducing colorectal cancer incidence","volume":"48","author":"Citarda","year":"2001","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJM199312303292701","article-title":"Prevention of Colorectal Cancer by Colonoscopic Polypectomy","volume":"329","author":"Winawer","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1053\/j.gastro.2012.06.001","article-title":"Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer","volume":"143","author":"Lieberman","year":"2012","journal-title":"Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJMoa1108895","article-title":"Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening","volume":"366","author":"Quintero","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/ajg.2014.168","article-title":"Attendance and Yield Over Three Rounds of Population-Based Fecal Immunochemical Test Screening","volume":"109","author":"Kapidzic","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.canep.2015.03.012","article-title":"Participation, yield, and interval carcinomas in three rounds of biennial FIT-based colorectal cancer screening","volume":"39","author":"Stegeman","year":"2015","journal-title":"Cancer Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/gutjnl-2011-301583","article-title":"Random comparison of repeated faecal immunochemical testing at different intervals for population-based colorectal cancer screening","volume":"62","author":"Goede","year":"2013","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Carethers, J.M. (2019). Fecal DNA Testing for Colorectal Cancer Screening. Annu. Rev. Med., 71.","DOI":"10.1146\/annurev-med-103018-123125"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2129","DOI":"10.1097\/MD.0000000000002129","article-title":"The Diagnostic Performance of Stool DNA Testing for Colorectal Cancer: A Systematic Review and Meta-Analysis","volume":"95","author":"Zhai","year":"2016","journal-title":"Medicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3816\/CCC.2011.n.002","article-title":"Molecular Tests for Colorectal Cancer Screening","volume":"10","author":"Bosch","year":"2011","journal-title":"Clin. Color. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1311194","article-title":"Multitarget stool DNA testing for colorectal-cancer screening","volume":"370","author":"Imperiale","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1034\/j.1399-0039.2002.590413.x","article-title":"Novel HLA-A locus alleles including A*01012, A*0306, A*0308, A*2616, A*2617, A*3009, A*3206, A*3403, A*3602 and A*6604","volume":"59","author":"Bradshaw","year":"2002","journal-title":"Tissue Antigens"},{"key":"ref_26","unstructured":"CBO (2019, November 04). Hereditary Colorectal Cancer, National Guideline. Available online: https:\/\/www.mdl.nl\/sites\/www.mdl.nl\/files\/richlijnen\/Erfelijke_darmkanker_-_december_2015_def.pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1001\/jamainternmed.2017.2309","article-title":"Diagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk for Colorectal Cancer: A Meta-analysis","volume":"177","author":"Katsoula","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1055\/a-0965-0605","article-title":"Endoscopic management of polyposis syndromes: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"51","author":"Roos","year":"2019","journal-title":"Endoscopy"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Rigter, L.S., Spaander, M.C.W., Moons, L.M., Bisseling, T.M., Aleman, B.M.P., De Boer, J.P., Lugtenburg, P.J., Janus, C.P.M., Petersen, E.J., and Roesink, J.M. (2017). Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: Study design. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3089-8"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"012799","DOI":"10.1136\/bmjopen-2016-012799","article-title":"STARD 2015 guidelines for reporting diagnostic accuracy studies: Explanation and elaboration","volume":"6","author":"Cohen","year":"2016","journal-title":"BMJ Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ijc.31233","article-title":"Quantitative fecal immunochemical tests for colorectal cancer screening","volume":"143","author":"Gies","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1053\/j.gastro.2016.11.022","article-title":"Real-Time Monitoring of Results During First Year of Dutch Colorectal Cancer Screening Program and Optimization by Altering Fecal Immunochemical Test Cut-Off Levels","volume":"152","author":"Dekker","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1053\/j.gastro.2011.07.020","article-title":"Cost-effectiveness Analysis of a Quantitative Immunochemical Test for Colorectal Cancer Screening","volume":"141","author":"Wilschut","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cgh.2016.07.029","article-title":"Fecal Immunochemical Test Detects Sessile Serrated Adenomas and Polyps With a Low Level of Sensitivity","volume":"15","author":"Chang","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/gutjnl-2015-310587","article-title":"Detection rate and predictive factors of sessile serrated polyps in an organised colorectal cancer screening programme with immunochemical faecal occult blood test: The EQuIPE study (Evaluating Quality Indicators of the Performance of Endoscopy)","volume":"66","author":"Zorzi","year":"2016","journal-title":"Gut"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1007\/s10620-019-05569-8","article-title":"Low Sensitivity of Fecal Immunochemical Tests and Blood-Based Markers of DNA Hypermethylation for Detection of Sessile Serrated Adenomas\/Polyps","volume":"64","author":"Cock","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Van Lanschot, M.C.J., Carvalho, B., Coup\u00e9, V.M.H., Van Engeland, M., Dekker, E., and Meijer, G.A. (2017). Molecular stool testing as an alternative for surveillance colonoscopy: A cross-sectional cohort study. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3078-y"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Naber, S.K., Knudsen, A.B., Zauber, A.G., Rutter, C.M., Fischer, S.E., Pabiniak, C.J., Soto, B., Kuntz, K.M., and Lansdorp-Vogelaar, I. (2019). Cost-effectiveness of a multitarget stool DNA test for colorectal cancer screening of Medicare beneficiaries. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220234"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Heigh, R.I., Yab, T.C., Taylor, W.R., Hussain, F.T.N., Smyrk, T.C., Mahoney, U.W., Domanico, M.J., Berger, B.M., Lidgard, G.P., and Ahlquist, D.A. (2014). Detection of Colorectal Serrated Polyps by Stool DNA Testing: Comparison with Fecal Immunochemical Testing for Occult Blood (FIT). PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085659"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/ajg.2012.249","article-title":"Immunochemical Fecal Occult Blood Testing Is Equally Sensitive for Proximal and Distal Advanced Neoplasia","volume":"107","author":"Stoop","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/hon.2402","article-title":"Late sequelae in Hodgkin lymphoma survivors","volume":"35","author":"Ng","year":"2017","journal-title":"Hematol. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"g2467","DOI":"10.1136\/bmj.g2467","article-title":"Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: Systematic review and meta-analysis of randomised controlled trials and observational studies","volume":"348","author":"Brenner","year":"2014","journal-title":"BMJ"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0016-5085(00)70168-5","article-title":"Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer","volume":"118","author":"Aarnio","year":"2000","journal-title":"Gastroenterology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/gutjnl-2018-317297","article-title":"Faecal immunochemical tests (FIT) versus colonoscopy for surveillance after screening and polypectomy: A diagnostic accuracy and cost-effectiveness study","volume":"68","author":"Cross","year":"2019","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/gutjnl-2011-300535","article-title":"Interval cancers in a FOBT-based colorectal cancer population screening programme: Implications for stage, gender and tumour site","volume":"61","author":"Steele","year":"2012","journal-title":"Gut"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1572-0241.2006.00390.x","article-title":"Polyp Miss Rate Determined by Tandem Colonoscopy: A Systematic Review","volume":"101","author":"Reitsma","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cgh.2017.07.011","article-title":"Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Noninvasive Colorectal Cancer Screening","volume":"16","author":"Goede","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/jnci\/djz060","article-title":"Cost-Effectiveness of Colonoscopy-Based Colorectal Cancer Screening in Childhood Cancer Survivors","volume":"111","author":"Gini","year":"2019","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/1\/190\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:42:39Z","timestamp":1760362959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/1\/190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["jcm9010190"],"URL":"https:\/\/doi.org\/10.3390\/jcm9010190","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2020,1,10]]}}}