{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:11:03Z","timestamp":1781277063198,"version":"3.54.1"},"reference-count":62,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00383"],"award-info":[{"award-number":["PI15\/00383"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD16\/00147"],"award-info":[{"award-number":["CD16\/00147"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII16\/00048"],"award-info":[{"award-number":["CPII16\/00048"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII19\/00003"],"award-info":[{"award-number":["CPII19\/00003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI17\/00294"],"award-info":[{"award-number":["FI17\/00294"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["FI_B00754"],"award-info":[{"award-number":["FI_B00754"]}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","award":["FI_B00783"],"award-info":[{"award-number":["FI_B00783"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study explored the brain structural correlates of psychological flexibility (PF) as measured with the Psychological Inflexibility in Pain Scale (PIPS) in patients with fibromyalgia (FM). Structural magnetic resonance imaging data from 47 FM patients were used to identify Gray Matter Volume (GMV) alterations related to PIPS scores. Brain GMV clusters related to PIPS were then correlated with clinical and cognitive variables to further explore how emerged brain clusters were intertwined with FM symptomatology. Longitudinal changes in PIPS-related brain clusters values were assessed by studying pre\u2013post data from 30 patients (15 allocated to a mindfulness-based stress reduction (MBSR) program and 15 to treatment-as-usual). Changes in PIPS-related brain clusters were also explored in participants showing greater\/lower longitudinal changes in PIPS scores. PIPS scores were positively associated with GMV in a bilateral cluster in the ventral part of the bed nucleus of the stria terminalis (BNST). Significant associations between BNST cluster with functional impairment, depressive symptomatology, perceived stress and the nonjudging mindfulness facet were observed. Participants reporting greater pre\u2013post increases in PIPS scores showed greater increases in BNST cluster values. These findings contribute to the understanding on the neurobiological bases of PF in FM and encourage further explorations of the role of the BNST in chronic pain.<\/jats:p>","DOI":"10.3390\/jcm9020374","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T11:55:56Z","timestamp":1580471756000},"page":"374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2810-7670","authenticated-orcid":false,"given":"Albert","family":"Feliu-Soler","sequence":"first","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"},{"name":"Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u, 08830 St. Boi de Llobregat, Spain"},{"name":"Faculty of Psychology, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4036-0284","authenticated-orcid":false,"given":"Ignacio","family":"Mart\u00ednez-Zalaca\u00edn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain"},{"name":"Department of Clinical Sciences, School of Medicine, University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"P\u00e9rez-Aranda","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"},{"name":"Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u, 08830 St. Boi de Llobregat, Spain"},{"name":"Faculty of Psychology, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-1385","authenticated-orcid":false,"given":"Xavier","family":"Borr\u00e0s","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Andr\u00e9s-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"},{"name":"Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u, 08830 St. Boi de Llobregat, Spain"},{"name":"Faculty of Psychology, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-435X","authenticated-orcid":false,"given":"Juan P.","family":"Sanabria-Mazo","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Fayed","sequence":"additional","affiliation":[{"name":"Department of Radiology, Quir\u00f3nsalud Hospital, 50012 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stephan-Otto","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"},{"name":"Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u, 08830 St. Boi de Llobregat, Spain"},{"name":"Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"},{"name":"Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u, 08830 St. Boi de Llobregat, Spain"},{"name":"Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-6597","authenticated-orcid":false,"given":"Carles","family":"Soriano-Mas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain"},{"name":"Department of Psychobiology and Methodology of Health Sciences, Universitat Aut\u00f2noma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0750-1599","authenticated-orcid":false,"given":"Juan V.","family":"Luciano","sequence":"additional","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u, 08950 Esplugues de Llobregat, Spain"},{"name":"Teaching, Research &amp; Innovation Unit, Parc Sanitari Sant Joan de D\u00e9u, 08830 St. Boi de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cpr.2012.10.006","article-title":"Mindfulness: Top-down or bottom-up emotion regulation strategy?","volume":"33","author":"Chiesa","year":"2013","journal-title":"Clin. Psychol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/1745691611419671","article-title":"How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective","volume":"6","author":"Lazar","year":"2011","journal-title":"Perspect. Psychol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4329\/wjr.v6.i7.471","article-title":"Neural mechanisms of mindfulness and meditation: Evidence from neuroimaging studies","volume":"6","author":"Marchand","year":"2014","journal-title":"World J. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrn3916","article-title":"The neuroscience of mindfulness meditation","volume":"16","author":"Tang","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/scan\/nss004","article-title":"Dispositional mindfulness and the attenuation of neural responses to emotional stimuli","volume":"8","author":"Brown","year":"2013","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/PSY.0b013e3180f6171f","article-title":"Neural correlates of dispositional mindfulness during affect labeling","volume":"69","author":"Creswell","year":"2007","journal-title":"Psychosom. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/scan\/nss030","article-title":"Neural correlates of focused attention during a brief mindfulness induction","volume":"8","author":"Dickenson","year":"2013","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroscience.2014.04.051","article-title":"The brain structure correlates of individual differences in trait mindfulness: A voxel-based morphometry study","volume":"272","author":"Lu","year":"2014","journal-title":"Neuroscience"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Murakami, H., Nakao, T., Matsunaga, M., Kasuya, Y., Shinoda, J., Yamada, J., and Ohira, H. (2012). The structure of mindful brain. PLoS One, 7.","DOI":"10.1371\/journal.pone.0046377"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Taren, A.A., Creswell, J.D., and Gianaros, P.J. (2013). Dispositional mindfulness co-varies with smaller amygdala and caudate volumes in community adults. PLoS One, 8.","DOI":"10.1371\/journal.pone.0064574"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1038\/s41598-017-06599-w","article-title":"A distinction between two instruments measuring dispositional mindfulness and the correlations between those measurements and the neuroanatomical structure","volume":"7","author":"Zhuang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bandc.2016.07.001","article-title":"8-week Mindfulness Based Stress Reduction induces brain changes similar to traditional long-term meditation practice\u2014A systematic review","volume":"108","author":"Gotink","year":"2016","journal-title":"Brain Cogn."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pscychresns.2010.08.006","article-title":"Mindfulness practice leads to increases in regional brain gray matter density","volume":"191","author":"Carmody","year":"2011","journal-title":"Psychiatry Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.neubiorev.2017.08.003","article-title":"The impact of mindfulness-based interventions on brain activity: A systematic review of functional magnetic resonance imaging studies","volume":"84","author":"Young","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_15","unstructured":"Hayes, S.C., Strosahl, K.D., Wilson, K.G., and Landau, L. (1999). Acceptance and Commitment Therapy: An Experiential Approach to Behavior Change, Guilford Press."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jpain.2013.10.014","article-title":"The psychological flexibility model: A basis for integration and progress in psychological approaches to chronic pain management","volume":"15","author":"McCracken","year":"2014","journal-title":"J. Pain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1477-7525-11-62","article-title":"Validation of a Spanish version of the psychological inflexibility in pain scale (PIPS) and an evaluation of its relation with acceptance of pain and mindfulness in sample of persons with fibromyalgia","volume":"11","author":"Rodero","year":"2013","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1027\/1015-5759\/a000191","article-title":"The Psychological Inflexibility in Pain Scale (PIPS) exploration of psychometric properties in a heterogeneous chronic pain sample","volume":"30","author":"Trompetter","year":"2014","journal-title":"Eur. J. Psychol. Assess."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cpr.2010.03.001","article-title":"Psychological flexibility as a fundamental aspect of health","volume":"30","author":"Kashdan","year":"2010","journal-title":"Clin. Psychol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.pain.2013.12.029","article-title":"Effectiveness of group acceptance and commitment therapy for fibromyalgia: A 6-month randomized controlled trial (EFFIGACT study)","volume":"155","author":"Luciano","year":"2014","journal-title":"Pain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pain.2009.10.034","article-title":"Psychological flexibility in adults with chronic pain: A study of acceptance, mindfulness, and values-based action in primary care","volume":"148","author":"McCracken","year":"2010","journal-title":"Pain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/AJP.0b013e31829ea187","article-title":"Psychological flexibility in coping with chronic pain: Further examination of the brief pain coping inventory-2","volume":"30","author":"Vowles","year":"2014","journal-title":"Clin. J. Pain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"771.e1","DOI":"10.1016\/j.ejpain.2009.11.015","article-title":"The Psychological Inflexibility in Pain Scale (PIPS) \u2014Statistical properties and model fit of an instrument to assess change processes in pain related disability","volume":"14","author":"Wicksell","year":"2010","journal-title":"Eur. J. Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ejpain.2007.08.003","article-title":"Avoidance and cognitive fusion\u2014Central components in pain related disability? Development and preliminary validation of the Psychological Inflexibility in Pain Scale (PIPS)","volume":"12","author":"Wicksell","year":"2008","journal-title":"Eur. J. Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.2147\/JPR.S144631","article-title":"Current status of acceptance and commitment therapy for chronic pain: A narrative review","volume":"11","author":"Montesinos","year":"2018","journal-title":"J. Pain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fpsyt.2017.00307","article-title":"Efficacy of \u201cattachment-based compassion therapy\u201d in the treatment of fibromyalgia: A randomized controlled trial","volume":"8","author":"Luciano","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/j.pain.0000000000001655","article-title":"A randomized controlled efficacy trial of mindfulness-based stress reduction compared with an active control group and usual care for fibromyalgia: The EUDAIMON study","volume":"160","author":"McCracken","year":"2019","journal-title":"Pain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/j.1532-2149.2012.00224.x","article-title":"Acceptance and commitment therapy for fibromyalgia: A randomized controlled trial","volume":"17","author":"Wicksell","year":"2013","journal-title":"Eur. J. Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1006\/nimg.2001.0961","article-title":"Why Voxel-based morphometry should be used","volume":"14","author":"Ashburner","year":"2001","journal-title":"Neuroimage"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Feliu-Soler, A., Borr\u00e0s, X., Pe\u00f1arrubia-Mar\u00eda, M.T., Rozadilla-Sacanell, A., D\u2019Amico, F., Moss-Morris, R., Howard, M.A., Fayed, N., Soriano-Mas, C., and Puebla-Guedea, M. (2016). Cost-utility and biological underpinnings of Mindfulness-Based Stress Reduction (MBSR) versus a psychoeducational programme (FibroQoL) for fibromyalgia: A 12-month randomised controlled trial (EUDAIMON study). BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1068-2"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/ar2783","article-title":"The revised fibromyalgia impact questionnaire (FIQR): Validation and psychometric properties","volume":"11","author":"Bennett","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/acr.22034","article-title":"Dimensionality, reliability, and validity of the revised fibromyalgia impact questionnaire in two spanish samples","volume":"65","author":"Luciano","year":"2013","journal-title":"Arthritis Care Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_34","unstructured":"Spacapan, S., and Oskamp, S. (1988). Perceived stress in a probability sample of the United States. The Social Psychology of Health: The Claremont Symposium on Applied Social Psychology, SAGE Publications."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1017\/S1138741600006004","article-title":"Psychometric properties of a European Spanish version of the Perceived Stress Scale (PSS)","volume":"9","author":"Remor","year":"2006","journal-title":"Span. J. Psychol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","article-title":"The pain catastrophizing scale: Development and validation","volume":"7","author":"Sullivan","year":"1995","journal-title":"Psychol. Assess."},{"key":"ref_37","first-page":"487","article-title":"Validation of the Spanish version of the Pain Catastrophizing Scale in fibromyalgia","volume":"131","author":"Rodero","year":"2008","journal-title":"Med. Clin."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1073191105283504","article-title":"Using self-report assessment methods to explore facets of mindfulness","volume":"13","author":"Baer","year":"2006","journal-title":"Assessment"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fpsyg.2015.00404","article-title":"Bifactor analysis and construct validity of the five facet mindfulness questionnaire (FFMQ) in non-clinical Spanish samples","volume":"6","author":"Aguado","year":"2015","journal-title":"Front. Psychol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/cpp.702","article-title":"Construction and factorial validation of a short form of the Self-Compassion Scale","volume":"18","author":"Raes","year":"2011","journal-title":"Clin. Psychol. Psychother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1477-7525-12-4","article-title":"Validation of the Spanish versions of the long (26 items) and short (12 items) forms of the Self-Compassion Scale (SCS)","volume":"12","author":"Demarzo","year":"2014","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_42","unstructured":"Ashburner, J., Barnes, G., Chen, C., Daunizeau, J., Flandin, G., Friston, K., and Penny, W. (2014). SPSM12 Manual, Wellcome Trust Centre for Neuroimaging."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"ref_44","unstructured":"IBM Corp (2016). IBM SPSS Statistics for Windows, Version 24.0, IBM Corp."},{"key":"ref_45","unstructured":"Mai, J.K., Paxinos, G., and Voss, T. (2008). Atlas of the Human Brain, Academic Press. [3rd ed.]."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neuroimage.2016.11.047","article-title":"Manual segmentation of the human bed nucleus of the stria terminalis using 3 T MRI","volume":"146","author":"Theiss","year":"2017","journal-title":"Neuroimage"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cortex.2014.11.013","article-title":"Ventromedial prefrontal cortex damage alters resting blood flow to the bed nucleus of stria terminalis","volume":"64","author":"Motzkin","year":"2015","journal-title":"Cortex"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: The bed nucleus of the stria terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3389\/fpsyt.2019.00510","article-title":"New frontiers in anxiety research: The translational potential of the bed nucleus of the stria terminalis","volume":"10","author":"Knight","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainresrev.2004.07.011","article-title":"Role of Noradrenergic Projections to the bed nucleus of the stria terminalis in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis","volume":"47","author":"Forray","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1523\/JNEUROSCI.0856-16.2016","article-title":"Functional heterogeneity in the bed nucleus of the stria terminalis","volume":"36","author":"Gungor","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neuropharm.2011.02.024","article-title":"Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders","volume":"62","author":"Hammack","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2519\/jospt.2016.0601","article-title":"Fear-avoidance beliefs and chronic pain","volume":"46","author":"Gatchel","year":"2016","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fnhum.2016.00386","article-title":"Neural correlates of fear of movement in patients with chronic low back pain vs. Pain-free individuals","volume":"10","author":"Meier","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fpsyt.2018.00029","article-title":"Threat response system: Parallel brain processes in pain vis-\u00e0-vis fear and anxiety","volume":"9","author":"Elman","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_56","first-page":"70","article-title":"Pain catastrophizing: What clinicians need to know","volume":"15","author":"Gatchel","year":"2017","journal-title":"Pract. Pain Manag."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1586\/ern.09.34","article-title":"Pain catastrophizing a critical review","volume":"9","author":"Quartana","year":"2009","journal-title":"Expert Rev. Neurother."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0304-3959(99)00242-0","article-title":"Fear-avoidance and its consequences in chronic musculoskeletal pain: A state of the art","volume":"85","author":"Vlaeyen","year":"2000","journal-title":"Pain"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/ejp.1003","article-title":"Brain changes associated with cognitive and emotional factors in chronic pain: A systematic review","volume":"21","author":"Malfliet","year":"2017","journal-title":"Eur. J. Pain"},{"key":"ref_60","first-page":"304","article-title":"Fibromyalgia impact and mindfulness characteristics in 4986 people with fibromyalgia","volume":"11","author":"Jones","year":"2015","journal-title":"Explor. J. Sci. Heal."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12671-012-0110-9","article-title":"The assessment of mindfulness with self-report measures: Existing scales and open issues","volume":"4","author":"Bergomi","year":"2013","journal-title":"Mindfulness"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrn3000","article-title":"The structural basis of inter-individual differences in human behaviour and cognition","volume":"12","author":"Kanai","year":"2011","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/2\/374\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:53:06Z","timestamp":1760172786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/2\/374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,30]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["jcm9020374"],"URL":"https:\/\/doi.org\/10.3390\/jcm9020374","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,30]]}}}