{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:56:46Z","timestamp":1773791806390,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In mouse models of squamous cell carcinoma, pre-treatment with calcitriol prior to photodynamic therapy with aminolevulinic acid (ALA) enhances tumor cell death. We have evaluated the association between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate. Twenty-five patients with actinic keratoses on the head received one session of photodynamic therapy with methylaminolevulinate. Biopsies were taken at baseline and six weeks after treatment. Immuno-histochemical staining was performed for VDR, P53, Ki67 and \u03b2-catenin. Basal serum 25(OH)D levels were determined. Cases with a positive histological response to treatment had significantly higher serum 25(OH)D levels (26.96 (SD 7.49) ngr\/mL) than those without response (18.60 (SE 7.49) ngr\/mL) (p = 0.05). Patients with a complete clinical response displayed lower basal VDR expression (35.71% (SD 19.88)) than partial responders (62.78% (SD 16.735)), (p = 0.002). Our results support a relationship between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate.<\/jats:p>","DOI":"10.3390\/jcm9020398","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T01:25:51Z","timestamp":1580693151000},"page":"398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-8364","authenticated-orcid":false,"given":"Ricardo","family":"Moreno","sequence":"first","affiliation":[{"name":"Dermatology Service, Hospital Univ. del Henares, Coslada, 28822 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"N\u00e1jera","sequence":"additional","affiliation":[{"name":"Pathology Service, Hospital Puerta de Hierro, Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Mascaraque","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-2887","authenticated-orcid":false,"given":"\u00c1ngeles","family":"Juarranz","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-4784","authenticated-orcid":false,"given":"Salvador","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Medicine and Medical Specialties Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Universidad de Alcal\u00e1, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-3617","authenticated-orcid":false,"given":"Yolanda","family":"Gilaberte","sequence":"additional","affiliation":[{"name":"Dermatology Service, Hospital Univ. Miguel Servet, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10552-004-1661-4","article-title":"The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)","volume":"16","author":"Giovannucci","year":"2005","journal-title":"Cancer Causes Control."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-3-642-55580-0_19","article-title":"Analysis of the Vitamin D system in Cutaneous Malignancies","volume":"164","author":"Kamradt","year":"2003","journal-title":"Recent Results Cancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jsbmb.2013.11.002","article-title":"Reciprocal role of vitamin D receptor on \u03b2-catenin regulated keratinocyte proliferation and differentiation","volume":"144","author":"Hu","year":"2014","journal-title":"J. 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