{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:26:23Z","timestamp":1760955983615,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:00Z","timestamp":1580774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>P2Y12 inhibitor discontinuation is essential before most surgical interventions to limit bleeding complications. Based on pharmacodynamic data, fixed discontinuation durations have been recommended. However, as platelet function recovery is highly variable among patients, a more individualized approach based on platelet function testing (PFT) has been proposed. The aim of this retrospective single-centre study was to determine whether PFT using whole blood adenosine diphosphate\u2013multiple electrode aggregometry (ADP\u2013MEA) was associated with a safe reduction of preoperative waiting time. Preoperative ADP\u2013MEA was performed for 29 patients on P2Y12 inhibitors. Among those, 17 patients underwent a coronary artery bypass graft. Twenty one were operated with an ADP\u2013MEA \u2265 19 U (quantification of the area under the aggregation curve), and the waiting time was shorter by 1.6 days (median 1.8 days, IQR 0.5\u20132.9), by comparison with the current recommendations (five days for clopidogrel and ticagrelor, seven days for prasugrel). Platelet function recovery was indeed highly variable among individuals. With the 19 U threshold, high residual platelet inhibition was associated with perioperative platelet transfusion. These results suggest that preoperative PFT with ADP\u2013MEA could help reduce waiting time before urgent surgery for patients on P2Y12 inhibitors.<\/jats:p>","DOI":"10.3390\/jcm9020424","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T02:59:18Z","timestamp":1580957958000},"page":"424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduction of Preoperative Waiting Time Before Urgent Surgery for Patients on P2Y12 Inhibitors Using Multiple Electrode Aggregometry: A Retrospective Study"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-9417","authenticated-orcid":false,"given":"Micha\u00ebl","family":"Hardy","sequence":"first","affiliation":[{"name":"Haematology Laboratory, NAmur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"},{"name":"Department of Anesthesiology, NAmur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camie","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, NAmur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-5601","authenticated-orcid":false,"given":"Anne-Sophie","family":"Dincq","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, NAmur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues","family":"Jacqmin","sequence":"additional","affiliation":[{"name":"Haematology Laboratory, NAmur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lecompte","sequence":"additional","affiliation":[{"name":"Departments of Medicine, University Hospitals of Geneva, and GpG-Faculty of Medicine Geneva University, 14 CH-1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Mullier","sequence":"additional","affiliation":[{"name":"Haematology Laboratory, NAmur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6689-6100","authenticated-orcid":false,"given":"Sarah","family":"Lessire","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, NAmur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Universit\u00e9 catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1161\/CIRCULATIONAHA.117.031164","article-title":"International Expert Consensus on Switching Platelet P2Y12 Receptor-Inhibiting Therapies","volume":"136","author":"Angiolillo","year":"2017","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0735-1097(02)01954-X","article-title":"The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting","volume":"40","author":"Hongo","year":"2002","journal-title":"J. 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