{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:12:16Z","timestamp":1779916336871,"version":"3.53.1"},"reference-count":50,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Intra-abdominal hypertension (IAH) causes severe organ dysfunction. Our aim is to evaluate the effect of increased intra-abdominal pressure (IAP) on renal function, hypothesizing that venous congestion may increase proteinuria and fluid retention without endothelial dysfunction. Three urine samples were collected from 32 non-pregnant women undergoing laparoscopic-assisted vaginal hysterectomy (LAVH) and from 10 controls placed in Trendelenburg position for 60 min. Urine sampling was done before (PRE), during or immediately after (PER), and two hours after (POST) the procedure. Urinary albumin, protein and creatinine concentrations were measured in each sample, and ratios were calculated and compared within and between groups. During LAVH, the albumin\/creatinine ratio (ACR) increased and persisted POST-procedure, which was not observed in controls. A positive correlation existed between the LAVH duration and the relative change in both ACR and protein\/creatinine ratio (PCR) PER- and POST-procedure. Iatrogenic IAH increases urinary ACR and PCR in non-pregnant women via a process of venous congestion. This mechanism might explain the presentation of one specific subtype of late-onset preeclampsia, where no drop of maternal cardiac output is observed.<\/jats:p>","DOI":"10.3390\/jcm9020487","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T11:45:30Z","timestamp":1581421530000},"page":"487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Increased Intra-Abdominal Pressure During Laparoscopic Pneumoperitoneum Enhances Albuminuria via Renal Venous Congestion, Illustrating Pathophysiological Aspects of High Output Preeclampsia"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4165-6121","authenticated-orcid":false,"given":"Pauline","family":"Dreesen","sequence":"first","affiliation":[{"name":"UHasselt\u2014Hasselt University, Faculty of Medicine and Life Sciences, Department of Physiology, Limburg Clinical Research Center, 3590 Diepenbeek, Belgium"},{"name":"Future Health, Ziekenhuis Oost-Limburg, 3600 Genk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie K.","family":"Schoutteten","sequence":"additional","affiliation":[{"name":"UHasselt\u2014Hasselt University, Faculty of Medicine and Life Sciences, Department of Physiology, Limburg Clinical Research Center, 3590 Diepenbeek, Belgium"},{"name":"Future Health, Ziekenhuis Oost-Limburg, 3600 Genk, Belgium"},{"name":"Department of Nephrology, Catharina Ziekenhuis, 5623 EJ Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Vande Velde","sequence":"additional","affiliation":[{"name":"UHasselt\u2014Hasselt University, Faculty of Medicine and Life Sciences, Department of Physiology, Limburg Clinical Research Center, 3590 Diepenbeek, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kaminski","sequence":"additional","affiliation":[{"name":"UHasselt\u2014Hasselt University, Faculty of Medicine and Life Sciences, Department of Physiology, Limburg Clinical Research Center, 3590 Diepenbeek, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Heylen","sequence":"additional","affiliation":[{"name":"UHasselt\u2014Hasselt University, Faculty of Medicine and Life Sciences, Department of Physiology, Limburg Clinical Research Center, 3590 Diepenbeek, Belgium"},{"name":"Department of Nephrology, Ziekenhuis Oost-Limburg, 3600 Genk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-2037","authenticated-orcid":false,"given":"Bart","family":"De Moor","sequence":"additional","affiliation":[{"name":"UHasselt\u2014Hasselt University, Faculty of Medicine and Life Sciences, Department of Physiology, Limburg Clinical Research Center, 3590 Diepenbeek, Belgium"},{"name":"Department of Nephrology, Jessa Ziekenhuis, 3500 Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-5255","authenticated-orcid":false,"given":"Manu L.N.G.","family":"Malbrain","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Universitair Ziekenhuis Brussel, 1090 Jette, Belgium"},{"name":"Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, 1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Gyselaers","sequence":"additional","affiliation":[{"name":"UHasselt\u2014Hasselt University, Faculty of Medicine and Life Sciences, Department of Physiology, Limburg Clinical Research Center, 3590 Diepenbeek, Belgium"},{"name":"Department of Obstetrics &amp; Gynecology, Ziekenhuis Oost-Limburg, 3600 Genk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.iccn.2018.06.001","article-title":"The gastro-renal effects of intra-abdominal hypertension: Implications for critical care nurses","volume":"48","author":"Gray","year":"2018","journal-title":"Intensive Crit. 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