{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:20:52Z","timestamp":1790785252136,"version":"4.1.0"},"reference-count":149,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Sudden cardiac death (SCD), most often induced by ventricular arrhythmias, is one of the main reasons for cardiovascular-related mortality. While coronary artery disease remains the leading cause of SCD, other pathologies like cardiomyopathies and, especially in the younger population, genetic disorders, are linked to arrhythmia-related mortality. Despite many efforts to enhance the efficiency of risk-stratification strategies, effective tools for risk assessment are still missing. Biomarkers have a major impact on clinical practice in various cardiac pathologies. While classic biomarkers like brain natriuretic peptide (BNP) and troponins are integrated into daily clinical practice, inflammatory biomarkers may also be helpful for risk assessment. Indeed, several trials investigated their application for the prediction of arrhythmic events indicating promising results. Furthermore, in recent years, active research efforts have brought forward an increasingly large number of \u201cnovel and alternative\u201d candidate markers of various pathophysiological origins. Investigations of these promising biological compounds have revealed encouraging results when evaluating the prediction of arrhythmic events. To elucidate this issue, we review current literature dealing with this topic. We highlight the potential of \u201cclassic\u201d but also \u201cnovel\u201d biomarkers as promising tools for arrhythmia prediction, which in the future might be integrated into clinical practice.<\/jats:p>","DOI":"10.3390\/jcm9020578","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T08:12:22Z","timestamp":1582618342000},"page":"578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Classic and Novel Biomarkers as Potential Predictors of Ventricular Arrhythmias and Sudden Cardiac Death"],"prefix":"10.3390","volume":"9","author":[{"given":"Zornitsa","family":"Shomanova","sequence":"first","affiliation":[{"name":"Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ohnewein","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-2880","authenticated-orcid":false,"given":"Christiane","family":"Schernthaner","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Killian","family":"H\u00f6fer","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Pogoda","sequence":"additional","affiliation":[{"name":"Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-9886","authenticated-orcid":false,"given":"Gerrit","family":"Frommeyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology II, Electrophysiology, University Hospital Muenster, Albert-Schweitzer-Campus 1, A1, D-48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-0220","authenticated-orcid":false,"given":"Bernhard","family":"Wernly","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias C.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Dieplinger","sequence":"additional","affiliation":[{"name":"Institute for Nursing and Practice, Paracelsus Medical University, Muellner Strubergasse 21, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta C.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Strohmer","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudin","family":"Pistulli","sequence":"additional","affiliation":[{"name":"Department of Cardiology I, Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas J.","family":"Motloch","sequence":"additional","affiliation":[{"name":"Clinic II for Internal Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"ref_1","unstructured":"(2020, January 28). 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