{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:18:32Z","timestamp":1773598712219,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T00:00:00Z","timestamp":1582329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Pigmented villonodular synovitis (PVNS) of the ankle is a very rare, locally aggressive, proliferative disorder. Although surgical excision represents the standard curative treatment, the PVNS relapse rate is high. We present our study of five young athletes (range 20\u201336 years) with a histopathological diagnosis of PVNS of the ankle, who were treated by surgery and adjuvant radiosynoviorthesis (RSO). The operation involved either arthroscopic (four patients) or open (one patient) debridement, followed by intraarticular RSO with the radiopharmaceutical erbium-169 (169Er). They were evaluated with the Foot Function Index (FFI) and a visual analog scale (VAS) for pain. At a median follow up period of 47 months (range 36\u201354 months), all five patients reported marked pain relief with improvements in their daily activities. In particular, the median FFI decreased from 77% (range 71.0%\u201384.5%) pre-treatment, to 0.5% (range 0%\u20136%) after treatment. The median VAS score decreased from 4 (range 3\u20137) to 0 (range 0\u20131), respectively. Throughout the follow-up period, there were no major complications regarding either therapeutic intervention (arthroscopic or open debridement, RSO). Based on these results, it can be concluded that adjuvant RSO with 169Er following surgical excision is effective and safe in the treatment of PVNS of the ankle.<\/jats:p>","DOI":"10.3390\/jcm9020597","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T08:12:22Z","timestamp":1582618342000},"page":"597","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series"],"prefix":"10.3390","volume":"9","author":[{"given":"Ioannis","family":"Iakovou","sequence":"first","affiliation":[{"name":"Academic Department of Nuclear Medicine, School of Medicine, University Hospital AHEPA, 54621 Thessaloniki, Greece"},{"name":"Department of Nuclear Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, 57006 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Symeonidis","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, St. Luke\u2019s Hospital, 55236 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kotrotsios","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, 57006 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evanthia","family":"Giannoula","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Aristotle University of Thessaloniki, Papageorgiou Hospital, 57006 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-8741","authenticated-orcid":false,"given":"Christos","family":"Sachpekidis","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Inselspital, Bern University Hospital, 3010 Bern, Switzerland"},{"name":"Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,22]]},"reference":[{"key":"ref_1","first-page":"335","article-title":"The pathogenesis and long-term end results of pigmented villonodular synovitis","volume":"114","author":"Granowitz","year":"1976","journal-title":"Clin. 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