{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:48:39Z","timestamp":1788281319545,"version":"build-2803163510"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Secondary hyperparathyroidism (SHPTH) is a major complication in patients on maintenance hemodialysis burdened with high cardiovascular risk. Hypertension is also a high prevalence complication contributing to an increase in the mortality rate in hemodialysis patients. A possible association between SHPTH and hypertension has been widely reported in the literature and several pathogenetic mechanisms have been described. There is evidence that the decrease of plasma iPTH levels are correlated with hypertension correction in hemodialysis patients undergoing parathyroidectomy and oral calcimimetics administration. We have observed a similar behaviour also in a patient on chronic hemodialysis treated with Etelcalcetide. Even if this is an isolated observation, it could stimulate future investigation, possibly in dedicated clinical trials.<\/jats:p>","DOI":"10.3390\/jcm9030629","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T07:50:53Z","timestamp":1583135453000},"page":"629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Secondary Hyperparathyroidism and Hypertension: An Intriguing Couple"],"prefix":"10.3390","volume":"9","author":[{"given":"Mariadelina","family":"Simeoni","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-9392","authenticated-orcid":false,"given":"Alessandra F.","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Fuiano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgery Sciences, \u2018Magna Graecia University\u2019, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/ckj\/sfz021","article-title":"Factors associated with parathyroid hormone control in haemodialysis patients with secondary hyperparathyroidism treated with cinacalcet in real-world clinical practice: Mimosa study","volume":"12","author":"Rottembourg","year":"2019","journal-title":"Clin. Kidney J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"van der Plas, W.Y., Noltes, M.E., van Ginhoven, T.M., and Kruijff, S. (2019). Secondary and Tertiary Hyperparathyroidism: A Narrative Review. Scand J. Surg.","DOI":"10.1177\/1457496919866015"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/0886022X.2016.1244077","article-title":"Quality of life, clinical outcome, personality and coping in chronic hemodialysis patients","volume":"39","author":"Simeoni","year":"2017","journal-title":"Ren. Fail."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/JIM.0000000000000140","article-title":"Serum \u03b2-Crosslaps as Predictor of Long-term Parathyroid Hormone Levels in Hemodialysis Patients","volume":"63","author":"Coppolino","year":"2015","journal-title":"J. Investig. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.ki.5002009","article-title":"Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease","volume":"71","author":"Levin","year":"2007","journal-title":"Kidney Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000380970","article-title":"Klotho\/FGF23 Axis in CKD","volume":"185","author":"Tsuchiya","year":"2015","journal-title":"Contrib. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1053\/j.jrn.2017.05.007","article-title":"ADAM17, a New Player in the Pathogenesis of Chronic Kidney Disease-Mineral and Bone Disorder","volume":"27","author":"Perna","year":"2017","journal-title":"J. Ren. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2215\/CJN.06040710","article-title":"Secondary hyperparathyroidism: Pathogenesis, disease progression, and therapeutic options","volume":"6","author":"Cunningham","year":"2011","journal-title":"Clin J. Am. Soc. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"RA1-11","DOI":"10.12659\/MSM.882181","article-title":"The mechanism of vascular calcification\u2014A systematic review","volume":"18","author":"Karwowski","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"ref_10","first-page":"473","article-title":"Prevalence of cardiovascular risk factors in hemodialysis patients\u2014The CORDIAL study","volume":"102","author":"Burmeister","year":"2014","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/sdi.12195","article-title":"Hypertension in hemodialysis patients: An opinion-based update","volume":"27","author":"Shafi","year":"2014","journal-title":"Semin. Dial."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2188\/jea.15.96","article-title":"Cardiovascular risk factors in hemodialysis patients: Results from baseline data of kaleidoscopic approaches to patients with end-stage renal disease study","volume":"15","author":"Ohsawa","year":"2005","journal-title":"J. Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0002-9343(03)00366-8","article-title":"Prevalence, treatment, and control of hypertension in chronic hemodialysis patients in the United States","volume":"115","author":"Agarwal","year":"2003","journal-title":"Am. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1097\/01.ASN.0000019641.41496.1E","article-title":"Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: The CHOICE Study","volume":"13","author":"Longenecker","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_15","first-page":"ME01-4","article-title":"High blood pressure in dialysis patients: Cause, pathophysiology, influence on morbidity, mortality and management","volume":"8","author":"Stern","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0272-6386(96)90519-3","article-title":"Blood pressure reduction after parathyroidectomy for secondary hyperparathyroidism: Further evidence implicating calcium homeostasis in blood pressure regulation","volume":"27","author":"Goldsmith","year":"1996","journal-title":"Am. J. Kidney Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sofronie, A.C., Kooij, I., Bursot, C., Santagati, G., Coindre, J.P., and Piccoli, G.B. (2018). Full normalization of severe hypertension after parathryoidectomy\u2014A case report and systematic review. BMC Nephrol., 19.","DOI":"10.1186\/s12882-018-0900-y"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000167211","article-title":"Serum Calcium, Parathyroid Hormone, and Blood Pressure","volume":"6","author":"Massry","year":"1986","journal-title":"Am. J. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2482-13-S2-S4","article-title":"Impact of parathyroidectomy on cardiovascular outcomes and survival in chronic hemodialysis patients with secondary hyperparathyroidism. A retrospective study of 50 cases prior to the calcimimetics era","volume":"13","author":"Conzo","year":"2013","journal-title":"BMC Surg."},{"key":"ref_20","first-page":"45","article-title":"Long-term effects of parathyroidectomy on cardiac and autonomic nervous system functions in haemodialysis patients","volume":"3","author":"Zucchelli","year":"1988","journal-title":"Nephrol Dial. Transpl."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"F1215","DOI":"10.1152\/ajprenal.00406.2006","article-title":"Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways","volume":"292","author":"Rashid","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.ehj.2003.09.010","article-title":"Parathyroid hormone and left ventricular hypertrophy","volume":"24","author":"Saleh","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14797\/mdcj-13-2-49","article-title":"The Parathyroid Gland and Heart Disease","volume":"13","author":"Brown","year":"2017","journal-title":"Methodist Debakey Cardiovasc. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2016.11.012","article-title":"Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho","volume":"100","author":"Yamada","year":"2017","journal-title":"Bone"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/emmm.201303716","article-title":"FGF23 regulates renal sodium handling and blood pressure","volume":"6","author":"Andrukhova","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"A69","DOI":"10.1046\/j.1440-1797.2002.00007-1-69.x","article-title":"Parathyroid hormone has a prosclerotic effect on vascular smooth muscle cells","volume":"7","author":"Perkovic","year":"2002","journal-title":"Nephrology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/SLA.0b013e3181f66720","article-title":"The Effects of Serum Calcium and Parathyroid Hormone Changes on Psychological and Cognitive Function in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism","volume":"253","author":"Roman","year":"2011","journal-title":"Ann. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000350160","article-title":"Parathyroidectomy Reduces Intradialytic Hypotension in Hemodialysis Patients with Secondary Hyperparathyroidism","volume":"37","author":"Shih","year":"2013","journal-title":"Kidney Blood Press. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/jhh.2012.49","article-title":"Severe and long-lasting hypotension occuring immediately after parathyroidectomy in hypertensive hemodialysis patients: A case series","volume":"27","author":"Leiba","year":"2013","journal-title":"J. Hum. Hypertens."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1053\/j.jrn.2010.06.004","article-title":"The High Prevalence of Alexithymia in Hemodialyzed Patients With Secondary Hyperparathyroidism Unsuppressed by Medical Therapy Is Cured by Parathyroidectomy","volume":"20","author":"Livrea","year":"2010","journal-title":"J. Ren. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000063291","article-title":"Effect of Parathyroidectomy on Blood Pressure in Dialysis Patients","volume":"92","author":"Almirall","year":"2002","journal-title":"Nephron"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0041-1345(02)02845-2","article-title":"Effects of secondary hyperparathyroidism treatments on blood pressure and lipid levels in chronic renal failure patients","volume":"34","author":"Saatci","year":"2002","journal-title":"Transpl. Proc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000045976","article-title":"Parathyroidectomy in Chronic Renal Failure: Short- and Long-Term Results on Parathyroid Function, Blood Pressure and Anemia","volume":"88","author":"Coen","year":"2001","journal-title":"Nephron"},{"key":"ref_34","first-page":"878","article-title":"Improved health-related quality of life and left ventricular hypertrophy among dialysis patients treated with parathyroidectomy","volume":"16","author":"Chow","year":"2003","journal-title":"J. Nephrol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/ckj\/sfx125","article-title":"Old and new calcimimetics for treatment of secondary hyperparathyroidism: Impact on biochemical and relevant clinical outcomes","volume":"11","author":"Pereira","year":"2018","journal-title":"Clin. Kidney J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"The EVOLVE Trial Investigators (2012). Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis. N. Engl. J. Med., 367, 2482\u20132494.","DOI":"10.1056\/NEJMoa1205624"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/jhh.2015.56","article-title":"The effects of cinacalcet on blood pressure, mortality and cardiovascular endpoints in the EVOLVE trial","volume":"30","author":"Chang","year":"2016","journal-title":"J. Hum. Hypertens."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/jama.2016.19456","article-title":"Effect of Etelcalcetide vs Placebo on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: Two Randomized Clinical Trials","volume":"317","author":"Block","year":"2017","journal-title":"JAMA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2016.19468","article-title":"Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial","volume":"317","author":"Block","year":"2017","journal-title":"JAMA"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Block, G.A., Chertow, G.M., Sullivan, J.T., Deng, H., Mather, O., Tomlin, H., and Serenko, M. (2019). An integrated analysis of safety and tolerability of etelcalcetide in patients receiving hemodialysis with secondary hyperparathyroidism. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0213774"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bushinsky, D.A., Chertow, G.M., Cheng, S., Deng, H., Kopyt, N., Martin, K.J., Rastogi, A., Ure\u00f1a-Torres, P., Vervloet, M., and Block, G.A. (2019). One-year safety and efficacy of intravenous etelcalcetide in patients on hemodialysis with secondary hyperparathyroidism. Nephrol. Dial. Transplant.","DOI":"10.1093\/ndt\/gfz111"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11255-015-1128-4","article-title":"Direct inhibition of plasmatic renin activity with aliskiren: A promising but under-investigated therapeutic option for non-diabetic glomerulonephritis","volume":"48","author":"Simeoni","year":"2016","journal-title":"Int. Urol. Nephrol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40620-015-0256-3","article-title":"How to improve duration and efficiency of the antiproteinuric response to Ramipril: RamiPROT\u2014A prospective cohort study","volume":"30","author":"Cianfrone","year":"2017","journal-title":"J. Nephrol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/3\/629\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:02:08Z","timestamp":1760173328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/3\/629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["jcm9030629"],"URL":"https:\/\/doi.org\/10.3390\/jcm9030629","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,27]]}}}