{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:37:23Z","timestamp":1793299043466,"version":"4.5.0"},"reference-count":15,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim of this study was to perform quantitative optical coherence tomography angiography (OCTA) assessment of arteritic and non-arteritic anterior ischemic optic neuropathies (AION; NAION). The study was designed as an observational, cross-sectional case series. All patients underwent complete ophthalmologic evaluation including LogMAR best-corrected visual acuity (BCVA), structural optical coherence tomography (OCT) and OCTA images, and dye-based angiography. Retinal nerve fiber layer (RNFL) thickness was obtained from structural OCT, and vessel density (VD) and vessel tortuosity (VT) were measured for each optic nerve head vascular plexus. After selecting the quadrants showing visual field defects, measured by Humphrey 30.2 perimetry (Zeiss Meditec, Dublin, CA, USA), we assessed the correlation between the localization of visual field defects and the quadrants showing impairments of RNFL, VD, and VT. Thirty na\u00efve AION patients (15 arteritic AION (AAION) and 15 non-arteritic AION (NAION)) were included. LogMAR BCVA was 0.6 \u00b1 0.2 for AAION and 0.3 \u00b1 0.3 for NAION (p &lt; 0.01). AAION and NAION eyes showed significant differences in terms of visual field involvement as well as VD and VT values, with remarkably worse alterations affecting AAION eyes. VD values perfectly matched with the quadrants showing RNFL and visual field defects. On the contrary, VT resulted remarkably decreased in all the quadrants, with even worse values in the quadrants showing RNFL and visual field alterations. The present study showed that AAION eyes are more injured than NAION ones. VD represents a good parameter for the detection of the main site on vascular impairment. Remarkably, VT resulted in a more sensitive parameter for the quantitative detection of blood flow impairment in AION disease.<\/jats:p>","DOI":"10.3390\/jcm9041094","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T03:10:01Z","timestamp":1586833801000},"page":"1094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Vessel Density and Vessel Tortuosity Quantitative Analysis of Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathies: An Optical Coherence Tomography Angiography Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Luisa","family":"Pierro","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-8414","authenticated-orcid":false,"given":"Alessandro","family":"Arrigo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Aragona","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-1201","authenticated-orcid":false,"given":"Michele","family":"Cavalleri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1007\/s00417-013-2399-z","article-title":"Ischemic optic neuropathies\u2014Where are we now?","volume":"251","author":"Hayreh","year":"2013","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1056\/NEJMra1413352","article-title":"Ischemic Optic Neuropathies","volume":"372","author":"Biousse","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/WNO.0000000000000493","article-title":"Optical Coherence Tomography Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy","volume":"37","author":"Cole","year":"2017","journal-title":"J. Neuroophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00417-017-3774-y","article-title":"Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy","volume":"255","author":"Balducci","year":"2017","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"071412","DOI":"10.1117\/1.JBO.19.7.071412","article-title":"Optical coherence tomography today: Speed, contrast, and multimodality","volume":"19","author":"Drexler","year":"2014","journal-title":"J. Biomed. Opt."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13365","DOI":"10.1364\/OE.24.013365","article-title":"MEMS-based handheld scanning probe with pre-shaped input signals for distortion-free images in Gabor-Domain Optical Coherence Microscopy","volume":"24","author":"Cogliati","year":"2016","journal-title":"Opt. Express."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40942-017-0068-9","article-title":"Impact of image quality on OCT angiography based quantitative measurements","volume":"3","author":"Akil","year":"2017","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/jemt.20829","article-title":"3D reconstruction of histological sections: Application to mammary gland tissue","volume":"73","year":"2010","journal-title":"Microsc. Res. Tech."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1080\/02713683.2018.1438630","article-title":"Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy","volume":"43","author":"Mastropasqua","year":"2018","journal-title":"Curr. Eye Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1167\/iovs.17-22996","article-title":"Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study","volume":"59","author":"Augstburger","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000489226","article-title":"Reduction of Peripapillary Vessel Density by Optical Coherence Tomography Angiography from the Acute to the Atrophic Stage in Non-Arteritic Anterior Ischaemic Optic Neuropathy","volume":"240","author":"Rebolleda","year":"2018","journal-title":"Ophthalmologica"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gaier, E.D., Wang, M., Gilbert, A.L., Rizzo, J.F., Cestari, D.M., and Miller, J.B. (2018). Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199793"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ajo.2018.08.001","article-title":"Advanced Optical Coherence Tomography Angiography Analysis of Age-related Macular Degeneration Complicated by Onset of Unilateral Choroidal Neovascularization","volume":"195","author":"Arrigo","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Arrigo, A., Romano, F., Aragona, E., Di Nunzio, C., Battista, M., Bandello, F., and Battaglia Parodi, M. (2020). Optical coherence tomography angiography can categorize different subgroups of choroidal neovascularization secondary to age-related macular degeneration. 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