{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:03:04Z","timestamp":1791925384540,"version":"4.3.4"},"reference-count":103,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Placental lactogen (PL) is a peptide hormone secreted throughout pregnancy by both animal and human specialized endocrine cells. PL plays an important role in the regulation of insulin secretion in pancreatic \u03b2-cells, stimulating their proliferation and promoting the expression of anti-apoptotic proteins. Cases of pregnancy affected by metabolic conditions, including obesity and diabetes, are related to alterations in the PL secretion pattern. Whereas obesity is most often associated with lower PL serum concentrations, diabetes results in increased PL blood levels. Disruptions in PL secretion are thought to be associated with an increased prevalence of gestational complications, such as placental dysfunction, diabetic retinopathy, and abnormalities in fetal growth. PL is believed to be positively correlated with birth weight. The impaired regulation of PL secretion could contribute to an increased incidence of both growth retardation and fetal macrosomia. Moreover, the dysregulation of PL production during the intrauterine period could affect the metabolic status in adulthood. PL concentration measurement could be useful in the prediction of fetal macrosomia in women with normal oral glucose tolerance test (OGTT) results or in evaluating the risk of fetal growth restriction, but its application in standard clinical practice seems to be limited in the era of ultrasonography.<\/jats:p>","DOI":"10.3390\/jcm9041142","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:01:39Z","timestamp":1587042099000},"page":"1142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8346-0085","authenticated-orcid":false,"given":"Rafa\u0142","family":"Sibiak","sequence":"first","affiliation":[{"name":"Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Pozna\u0144 University of Medical Sciences, 33 Polna St, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-0235","authenticated-orcid":false,"given":"Maurycy","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pozna\u0144 University of Medical Sciences, 6 \u015awi\u0119cickiego St, 60-781 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Gutaj","sequence":"additional","affiliation":[{"name":"Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Pozna\u0144 University of Medical Sciences, 33 Polna St, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-3123","authenticated-orcid":false,"given":"Paul","family":"Mozdziak","sequence":"additional","affiliation":[{"name":"Physiology Graduate Program, North Carolina State University, Campus Box 7608, Raleigh, NC 27695-7608, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Kempisty","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pozna\u0144 University of Medical Sciences, 6 \u015awi\u0119cickiego St, 60-781 Poznan, Poland"},{"name":"Department of Histology and Embryology, Pozna\u0144 University of Medical Sciences, 6 \u015awi\u0119cickiego St, 60-781 Poznan, Poland"},{"name":"Department of Obstetrics and Gynecology, University Hospital and Masaryk University, 20 Jihlavsk\u00e1 St., 625 00 Brno, Czech Republic"},{"name":"Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Toru\u0144, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wender-O\u017cegowska","sequence":"additional","affiliation":[{"name":"Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Pozna\u0144 University of Medical Sciences, 33 Polna St, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Prevalence of Obesity Among Adults and Youth: United States, 2015-2016","volume":"288","author":"Hales","year":"2017","journal-title":"NCHS Data Brief"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam","year":"2005","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Guh, D.P., Zhang, W., Bansback, N., Amarsi, Z., Birmingham, C.L., and Anis, A.H. 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