{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:30:16Z","timestamp":1792251016194,"version":"4.4.0"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: To elucidate the clinical features of ocular motility and the risk factors for recurrence in idiopathic orbital myositis. Methods: The medical records of 31 patients diagnosed with idiopathic orbital inflammation between 2003 and 2019 were retrospectively reviewed. All patients were initially treated with corticosteroids. Treatment outcome and ocular motility were noted. Results: Twenty-six patients (84%) had unilateral involvement and five patients (16%) were bilateral. Of the 31 patients, 22 patients (71%) showed ocular motility limitation. The mean grading scale of extraocular muscle (EOM) limitation was \u22121.65 \u00b1 1.80. EOM limitation was found in the same direction of the most affected muscle in 14 patients (64%), while 8 patients (36%) showed duction limitation in the opposite direction. Nine patients (35%) suffered from recurrence. Recurrence was more likely to occur in patients with multiple muscle involvement (p &lt; 0.001). The interval to relapse of symptoms after discontinuation of steroids was significantly shorter in patients with multiple recurrences compared to those with a single recurrence (1.8 \u00b1 0.8 weeks versus 6.0 \u00b1 1.4 weeks, p = 0.020). Conclusions: Idiopathic orbital myositis showed variable degrees of ocular motility limitation, and limitation in the same direction of the action of the affected muscle was more frequent. Recurrent myositis was more likely to have multiple muscle involvement. Rapid relapse of symptoms after discontinuation of steroids was a significant indicator of multiple recurrences.<\/jats:p>","DOI":"10.3390\/jcm9041165","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T05:48:52Z","timestamp":1587448132000},"page":"1165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Clinical Features of Ocular Motility in Idiopathic Orbital Myositis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-3706","authenticated-orcid":false,"given":"Min Seok","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kim\u2019s Eye Hospital, Seoul 07301, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-6036","authenticated-orcid":false,"given":"Hee Kyung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-2864","authenticated-orcid":false,"given":"Jeong-Min","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/archopht.121.4.491","article-title":"Idiopathic orbital inflammation: Distribution, clinical features, and treatment outcome","volume":"121","author":"Yuen","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"ref_2","first-page":"471","article-title":"Idiopathic myositis involving the intraocular muscles","volume":"12","author":"Gleason","year":"1903","journal-title":"Ophthalmol. Rec."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0002-9394(66)91488-7","article-title":"Chronic orbital myositis. Its diagnostic difficulties and pathology","volume":"62","author":"Wolter","year":"1966","journal-title":"Am. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0039-6257(84)90166-8","article-title":"The nonspecific orbital inflammatory syndromes","volume":"29","author":"Kennerdell","year":"1984","journal-title":"Surv. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0161-6420(97)30300-5","article-title":"Outcome of orbital myositis. Clinical features associated with recurrence","volume":"104","author":"Mannor","year":"1997","journal-title":"Ophthalmology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1136\/bjo.2007.124156","article-title":"Idiopathic orbital inflammatory syndrome: Clinical features and treatment outcomes","volume":"91","author":"Swamy","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0140-6736(14)60720-0","article-title":"IgG4-related disease","volume":"385","author":"Kamisawa","year":"2015","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/art.39205","article-title":"IgG4-related disease: Clinical and laboratory features in one hundred twenty-five patients","volume":"67","author":"Wallace","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMra1104650","article-title":"IgG4-related disease","volume":"366","author":"Stone","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1755-3768.2012.02526.x","article-title":"IgG4-related orbital disease: A meta-analysis and review","volume":"91","author":"Andrew","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00417-013-2548-4","article-title":"Location and frequency of lesions in patients with IgG4-related ophthalmic diseases","volume":"252","author":"Sogabe","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.semarthrit.2013.11.008","article-title":"Ophthalmic manifestations of IgG4-related disease: Single-center experience and literature review","volume":"43","author":"Wallace","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"635473","DOI":"10.1155\/2012\/635473","article-title":"Clinical aspects of IgG4-related orbital inflammation in a case series of ocular adnexal lymphoproliferative disorders","volume":"2012","author":"Takahira","year":"2012","journal-title":"Int. J. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10384-014-0353-1","article-title":"Ocular adnexal IgG4-related disease: Clinical features, outcome, and factors associated with response to systemic steroids","volume":"59","author":"Yu","year":"2015","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"412896","DOI":"10.5402\/2012\/412896","article-title":"Orbital IgG4-related disease: Clinical features and diagnosis","volume":"2012","author":"Kubota","year":"2012","journal-title":"ISRN Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ophtha.2013.12.028","article-title":"Enlargement of the infraorbital nerve: An important sign associated with orbital reactive lymphoid hyperplasia or immunoglobulin G4-related disease","volume":"121","author":"Hardy","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10384-011-0014-6","article-title":"A case of extraocular muscle swelling due to IgG4-related sclerosing disease","volume":"55","author":"Higashiyama","year":"2011","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.clinimag.2011.12.012","article-title":"Case report of systemic IgG-related disease affecting the pancreas and orbit","volume":"36","author":"Arfenoni","year":"2012","journal-title":"Clin. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000444164","article-title":"Acute painful ptosis secondary to IgG4 dacryoadenitis","volume":"7","author":"Hussain","year":"2016","journal-title":"Case Rep. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00417-013-2541-y","article-title":"Clinical features of IgG4-related dacryoadenitis","volume":"252","author":"Koizumi","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1136\/bjo.2010.191866","article-title":"Relapsing migratory idiopathic orbital inflammation: Six new cases and review of the literature","volume":"96","author":"Tripathy","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10384-014-0352-2","article-title":"Japanese study group for IgG4-related ophthalmic disease. Diagnostic criteria for IgG4-related ophthalmic disease","volume":"59","author":"Goto","year":"2015","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.semarthrit.2007.06.003","article-title":"Orbital inflammatory disease","volume":"37","author":"Lutt","year":"2008","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/meajo.MEAJO_44_18","article-title":"Idiopathic orbital inflammation: Review of literature and new advances","volume":"25","author":"Ahmet","year":"2018","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/bjo.52.2.79","article-title":"Inflammatory pseudotumor of the orbit","volume":"52","author":"Blodi","year":"1968","journal-title":"Br. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/eye.1995.15","article-title":"Acute orbital myositis","volume":"9","author":"Moorman","year":"1995","journal-title":"Eye"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0039-6257(99)00101-0","article-title":"Nonthyroid causes of extraocular muscle disease","volume":"44","author":"Lacey","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00004397-199603610-00017","article-title":"Pediatric orbital pseudotumor: Case report and review of the literature","volume":"36","author":"Berger","year":"1996","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_29","first-page":"112","article-title":"Bilateral idiopathic orbital myositis in an infant","volume":"2","author":"Benmiloud","year":"2013","journal-title":"Int. J. Res. Med."},{"key":"ref_30","first-page":"37","article-title":"Ocular myositis: Diagnostic assessment, differential diagnoses, and therapy of a rare muscle disease\u2014Five new cases and review","volume":"1","author":"Schoser","year":"2007","journal-title":"Clin. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0161-6420(80)35223-8","article-title":"Submillimeter resolution CT scanning of orbital diseases","volume":"87","author":"Trokel","year":"1980","journal-title":"Ophthalmology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0002-9394(79)90239-3","article-title":"Recognition and differential diagnosis of enlarged extraocular muscles in computed tomography","volume":"87","author":"Trokel","year":"1979","journal-title":"Am. J. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3174\/ajnr.A1751","article-title":"Recurrent orbital myositis mimicking sixth nerve palsy: Diagnosis with MR imaging","volume":"31","author":"Fischer","year":"2010","journal-title":"Am. J. Neuroradiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5152\/npa.2015.10214","article-title":"Orbital myositis: Evaluating five new cases regarding clinical and radiological features","volume":"53","year":"2016","journal-title":"Arch. Neuropsychiatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3928\/01913913-20160506-02","article-title":"Extraocular muscle fibrosis in idiopathic orbital inflammation","volume":"53","author":"Kinori","year":"2016","journal-title":"J. Pediatr. Ophthalmol. Strabismus"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0161-6420(97)30301-7","article-title":"Current status in the treatment of orbital myositis","volume":"104","author":"Mombaerts","year":"1997","journal-title":"Ophthalmology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0161-6420(85)33854-X","article-title":"Treatment protocol for orbital inflammatory disease","volume":"92","author":"Leone","year":"1985","journal-title":"Ophthalmology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/sj.eye.6702383","article-title":"Orbital inflammatory disease: A diagnostic and therapeutic challenge","volume":"20","author":"Gordon","year":"2006","journal-title":"Eye"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/4\/1165\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:45:06Z","timestamp":1760363106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/4\/1165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,18]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["jcm9041165"],"URL":"https:\/\/doi.org\/10.3390\/jcm9041165","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,18]]}}}