{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:14:45Z","timestamp":1790874885339,"version":"4.1.0"},"reference-count":65,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In patients with interstitial lung disease (ILD) next to dyspnea, fatigue is expected to be the most prevalent symptom. Surprisingly, the prevalence of severe fatigue has been scarcely studied in ILD patients and limited information on its associated factors is available. This study aimed to determine the prevalence of severe fatigue in patients with idiopathic pulmonary fibrosis (IPF) or pulmonary sarcoidosis and to identify the relationship between fatigue, patient characteristics, and clinical parameters. In this cross-sectional study, fatigue (checklist individual strength-fatigue (CIS-Fat)), demographics, lung function, dyspnea (modified-Medical Research Council (mMRC)), sleepiness (Epworth Sleepiness Scale), anxiety\/depression (hospital anxiety and depression scale (HADS-A\/HADS-D)), catastrophizing (fatigue catastrophizing scale (FCS)), functional activity impairment (respiratory illness quality-of-life (QoL-RIQ-Activity)), and health status (EuroQol five-dimensional descriptive system (EQ-5D-5L)) were assessed in outpatients with ILD. Mean CIS-Fat scores were 34.1 (SD \u00b1 11.2) in 59 IPF patients and 40.0 (12.3) in 58 sarcoidosis patients. Severe fatigue (SD \u00b1 \u226536 points) was present in IPF patients (47.5%) and sarcoidosis (69%). In IPF, CIS-Fat correlated strongly (\u03c1 &gt; 0.5; p &lt; 0.01) with FCS, QoL-RIQ-Activity, and EQ-5D-5L-Health and moderately (0.3 &lt; \u03c1 &lt; 0.5; p &lt; 0.01) with EQ-5D-5L-Index, mMRC, and HADS-D. In sarcoidosis, CIS-Fat correlated strongly with EQ-5D-5L-Health, QoL-RIQ-Activity, EQ-5D-5L-Index, HADS-D, and mMRC and moderately with FCS and hospitalization &lt;12 months. Severe fatigue is highly prevalent in ILD patients and is associated with dyspnea, depression, catastrophizing, functional activity impairments, and QoL.<\/jats:p>","DOI":"10.3390\/jcm9041178","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T05:48:52Z","timestamp":1587448132000},"page":"1178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Severe Fatigue is Highly Prevalent in Patients with IPF or Sarcoidosis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-4697","authenticated-orcid":false,"given":"Ada E. M.","family":"Bloem","sequence":"first","affiliation":[{"name":"Institute of Movement Studies, Faculty of Health Care, University of Applied Sciences Utrecht, 3584 CS Utrecht, The Netherlands"},{"name":"ILD Centre of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my L. M.","family":"Mostard","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Zuyderland Medical Center Heerlen, 6419 PC Heerlen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Stoot","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Zuyderland Medical Center Heerlen, 6419 PC Heerlen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Vercoulen","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Radboud University Medical Center, Radboud Institute for Health Sciences, 6525 EZ Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4592-7275","authenticated-orcid":false,"given":"Jeannette B.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Radboud University Medical Center, Radboud Institute for Health Sciences, 6525 EZ Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1827-9869","authenticated-orcid":false,"given":"Daisy J. A.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Research and Development, CIRO, 6085 NM Horn, The Netherlands"},{"name":"Department of Health Services Research, Care and Public Health Research Institute, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-1567","authenticated-orcid":false,"given":"Jan W. H.","family":"Custers","sequence":"additional","affiliation":[{"name":"Institute of Movement Studies, Faculty of Health Care, University of Applied Sciences Utrecht, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-7430","authenticated-orcid":false,"given":"Martijn A.","family":"Spruit","sequence":"additional","affiliation":[{"name":"Department of Research and Development, CIRO, 6085 NM Horn, The Netherlands"},{"name":"Department of Respiratory Medicine, Maastricht University Medical Center, NUTRIM School of Nutrition and Translational Research in Metabolism, 6229 ER Maastricht, The Netherlands"},{"name":"REVAL\u2014Rehabilitation Research Center, BIOMED\u2014Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, BE 3500 Diepenbeek, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1136\/thx.2008.101691","article-title":"Interstitial lung disease guideline: The British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society","volume":"63","author":"Bradley","year":"2008","journal-title":"Thorax"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis","year":"2013","journal-title":"Am. 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