{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:12:22Z","timestamp":1760364742405,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Bicuspid aortic valve (BAV) is a common congenital heart diagnosis and is associated with aortopathy. Current guidelines for aortic resection have been validated but are based on aortic diameter, which is insufficient to predict acute aortic events. Clinical and translational collaboration is necessary to identify biomarkers that can individualize the timing of prophylactic surgery for BAV aortopathy. We describe our multidisciplinary BAV program, including research protocols aimed at biomarker discovery and results from our longitudinal clinical registry. From 2012\u20132018, 887 patients enrolled in our clinical BAV registry with the option to undergo four dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR) and donate serum plasma or tissue samples. Of 887 patients, 388 (44%) had an elective BAV-related procedure after initial presentation, while 499 (56%) continued with medical management. Of medical patients, 44 (9%) had elective surgery after 2.3 \u00b1 1.4 years. Surgery patients\u2019 biobank donations include 198 (46%) aorta, 374 (86%) aortic valve, and 314 (73%) plasma samples. The 4D flow CMR was completed for 215 (50%) surgery patients and 243 (49%) medical patients. Patients with BAV aortopathy can be safely followed by a multidisciplinary team to detect indications for surgery. Paired tissue and hemodynamic analysis holds opportunity for biomarker development in BAV aortopathy.<\/jats:p>","DOI":"10.3390\/jcm9051354","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T04:46:07Z","timestamp":1588826767000},"page":"1354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Applications of a Specialty Bicuspid Aortic Valve Program: Clinical Continuity and Translational Collaboration"],"prefix":"10.3390","volume":"9","author":[{"given":"Erin E.","family":"Crawford","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Northwestern Medicine, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Northwestern Medicine, Chicago, IL 60611, USA"},{"name":"Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-0334","authenticated-orcid":false,"given":"S. Chris","family":"Malaisrie","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Northwestern Medicine, Chicago, IL 60611, USA"},{"name":"Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyothy J.","family":"Puthumana","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Northwestern Medicine, Chicago, IL 60611, USA"},{"name":"Department of Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ann &amp; Robert H Lurie Children\u2019s Hospital of Chicago, Chicago, IL 60611, USA"},{"name":"Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"},{"name":"Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"},{"name":"McCormick School of Engineering, Evanston, IL 60208, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Northwestern Medicine, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adin-Cristian","family":"Andrei","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Guzzardi","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Libin Cardiovascular Institute, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Kruse","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Northwestern Medicine, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-9381","authenticated-orcid":false,"given":"Paul W. M.","family":"Fedak","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Northwestern Medicine, Chicago, IL 60611, USA"},{"name":"Section of Cardiac Surgery, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Libin Cardiovascular Institute, Calgary, AB T2N 4N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jtcvs.2015.12.019","article-title":"Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves","volume":"151","author":"Masri","year":"2016","journal-title":"J. Thorac. Cardiovasc. 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