{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:14Z","timestamp":1787028674717,"version":"build-2736575974"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 \u00d7 8 posterior pole algorithm (8 \u00d7 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Thinning of superior and inferior hemisphere mean thickness in mRNFL, GCL and IPL and thickening of superior and inferior hemisphere mean thickness in PRL and inferior hemisphere in INL were found in early GPAA group. Otherwise, heatmaps representing cell-to-cell comparisons showed thinning patterns in inner retinal layers (except for INL) and thickening patterns in outer retinal layers in GPAA group. We found that 8 \u00d7 8 PPA not only allows the detection of significant thinning patterns in inner retinal layers, but also thickening patterns in outer retinal layers when comparing early POAG eyes to OHT eyes.<\/jats:p>","DOI":"10.3390\/jcm9051503","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T11:34:14Z","timestamp":1589801654000},"page":"1503","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 \u00d7 8 Posterior Pole Algorithm of SD-OCT"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-7271","authenticated-orcid":false,"given":"Jose","family":"Garcia-Medina","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, General University Hospital Morales Meseguer, 30007 Murcia, Spain"},{"name":"Department of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain"},{"name":"Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain"},{"name":"Ophthalmic Research Unit Santiago Grisolia\/FISABIO, 46017 Valencia, Spain"},{"name":"Cellular and Molecular Ophthalmolobiology Group, Surgery Department of the University of Valencia, 46010 Valencia, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Patolog\u00eda Ocular (OFTARED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"del-Rio-Vellosillo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Palazon-Cabanes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-7837","authenticated-orcid":false,"given":"Maria","family":"Pinazo-Duran","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Unit Santiago Grisolia\/FISABIO, 46017 Valencia, Spain"},{"name":"Cellular and Molecular Ophthalmolobiology Group, Surgery Department of the University of Valencia, 46010 Valencia, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Patolog\u00eda Ocular (OFTARED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-1592","authenticated-orcid":false,"given":"Vicente","family":"Zanon-Moreno","sequence":"additional","affiliation":[{"name":"Area of Health Sciences, Valencian International University, 46002 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-482X","authenticated-orcid":false,"given":"Maria","family":"Villegas-Perez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain"},{"name":"Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Patolog\u00eda Ocular (OFTARED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. 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