{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:29:26Z","timestamp":1791336566394,"version":"4.3.1"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["OFTARED (RD16\/0008\/0005)"],"award-info":[{"award-number":["OFTARED (RD16\/0008\/0005)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RETIBRAIN (RED2018-102499-T)"],"award-info":[{"award-number":["RETIBRAIN (RED2018-102499-T)"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["CT42\/18-CT43\/18"],"award-info":[{"award-number":["CT42\/18-CT43\/18"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["FPU17\/01023"],"award-info":[{"award-number":["FPU17\/01023"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer\u2019s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE \u025b4 carriers and 29 age-matched control subjects without a family history of AD (FH\u2212) and ApoE \u025b4 non-carriers were included. Compared to FH\u2212 ApoE \u025b4 non-carriers, in FH+ ApoE \u025b4 carriers, there were statistically significant decreases (p &lt; 0.05) in (i) the foveal area of mRNFL; (ii) the inferior and nasal sectors in the outer and inner macular ring in the inner plexiform layer (IPL); (iii) the foveal area and the inferior sector in the outer macular ring in the inner nuclear layer (INL); and (iv) the inferior sector of the outer macular ring in the outer plexiform layer (OPL). However, no statistically significant differences were found in the peripapillary thickness of RNFL between both study groups. In subjects with cognitive health and high genetic risk for the development of AD, initial changes appeared in the macular area. OCT could be a promising, cost-effective and non-invasive test useful in early AD, before the onset of clinical symptoms.<\/jats:p>","DOI":"10.3390\/jcm9061728","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T04:36:09Z","timestamp":1591245369000},"page":"1728","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer\u2019s Disease: An OCT Study"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-515X","authenticated-orcid":false,"given":"In\u00e9s","family":"L\u00f3pez-Cuenca","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Oftalmol\u00f3gicas Ram\u00f3n Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-7996","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Fern\u00e1ndez-Albarral","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Oftalmol\u00f3gicas Ram\u00f3n Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2383-1563","authenticated-orcid":false,"given":"Ana","family":"Barabash","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Cl\u00ednico Universitario San Carlos and Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas, 28029 Madrid, 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