{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:48:23Z","timestamp":1770839303745,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Andras Guttman","award":["NKFIH-SNN-NN-132999-2019]; [NN-127062]; [2018-2.1.17-T\u00c9T-KR-2018-00010]; [BIONANO_GINOP-2.3.2-15-2016-00017]"],"award-info":[{"award-number":["NKFIH-SNN-NN-132999-2019]; [NN-127062]; [2018-2.1.17-T\u00c9T-KR-2018-00010]; [BIONANO_GINOP-2.3.2-15-2016-00017]"]}]},{"name":"Tibor Hortobagyi","award":["[2017-1.2.1-NKP-2017-00002]"],"award-info":[{"award-number":["[2017-1.2.1-NKP-2017-00002]"]}]},{"name":"Csaba Hegedus","award":["[GINOP-2.3.2.15-2016-0001]"],"award-info":[{"award-number":["[GINOP-2.3.2.15-2016-0001]"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality. Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense. Altered salivary sialoglycoprotein carbohydrates are important in the pathologies in the oral cavity including inflammation, infection and neoplasia. Therefore, we assessed whether changes in the salivary and serum IgA glycosylation correlated with development and severity of oral mucositis. Methods: Using capillary electrophoresis, comparative analysis of serum and salivary IgA total N-glycans was conducted in 8 patients with autologous peripheral stem-cell transplantation (APSCT) at four different stages of transplantation (day \u22123\/\u22127, 0, +7, +14) and in 10 healthy controls. Results: Fourteen out of the 31 structures identified in serum and 6 out of 38 in saliva showed significant changes upon transplantation compared with the control group. Only serum core fucosylated, sialylated bisecting biantennary glycan (FA2BG2S2) showed significant differences between any two stages of transplantation (day \u22123\/\u22127 and day +14; p = 0.0279). Conclusion: Our results suggest that changes in the serum IgA total N-glycan profile could serve as a disease-specific biomarker in patients undergoing APSCT, while analysis of salivary IgA N-glycan reflects the effect of APSCT on local immunity.<\/jats:p>","DOI":"10.3390\/jcm9061747","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T06:34:16Z","timestamp":1591684456000},"page":"1747","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["N-Glycosylation Alteration of Serum and Salivary Immunoglobulin A Is a Possible Biomarker in Oral Mucositis"],"prefix":"10.3390","volume":"9","author":[{"given":"Enik\u0151","family":"Gebri","sequence":"first","affiliation":[{"name":"Department of Dentoalveolar Surgery and Dental Outpatient Care, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-0456","authenticated-orcid":false,"given":"Zsuzsanna","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Horv\u00e1th Csaba Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Doctoral School of Molecular Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"},{"name":"Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u 10., H-8200 Veszpr\u00e9m, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitta","family":"M\u00e9sz\u00e1ros","sequence":"additional","affiliation":[{"name":"Horv\u00e1th Csaba Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Doctoral School of Molecular Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"},{"name":"Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u 10., H-8200 Veszpr\u00e9m, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1170-6274","authenticated-orcid":false,"given":"Ferenc","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-8773","authenticated-orcid":false,"given":"\u00c1d\u00e1m","family":"Simon","sequence":"additional","affiliation":[{"name":"Horv\u00e1th Csaba Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Doctoral School of Molecular Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajnalka","family":"Jankovics","sequence":"additional","affiliation":[{"name":"Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u 10., H-8200 Veszpr\u00e9m, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Vonderviszt","sequence":"additional","affiliation":[{"name":"Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u 10., H-8200 Veszpr\u00e9m, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Transplantation Centre, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Guttman","sequence":"additional","affiliation":[{"name":"Horv\u00e1th Csaba Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Doctoral School of Molecular Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"},{"name":"Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u 10., H-8200 Veszpr\u00e9m, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-7942","authenticated-orcid":false,"given":"Tibor","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Szeged, \u00c1llom\u00e1s utca 1., H-6725 Szeged, Hungary"},{"name":"MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary"},{"name":"Institute of Psychiatry Psychology and Neuroscience, King\u2019s College London, De Crespigny Park, London SE5 8AF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2006.08.019","article-title":"Glycosylation in Cellular Mechanisms of Health and Disease","volume":"126","author":"Ohtsubo","year":"2006","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.molmed.2008.06.002","article-title":"Sialic acids in human health and disease","volume":"14","author":"Varki","year":"2008","journal-title":"Trends Mol. 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