{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:04:16Z","timestamp":1790773456037,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation (NRF) grant funded by the Korea government","award":["NRF-2017R1A2B2009596"],"award-info":[{"award-number":["NRF-2017R1A2B2009596"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Limited studies have examined the intestinal microbiota composition in relation to Crohn\u2019s disease (CD) prognosis. We analyzed the differences in microbial communities and relevant metabolic pathways associated with prognostic variables in patients with CD. We applied 16S rRNA gene sequencing to analyze a cohort of 1110 CD and healthy control (HC) fecal samples. We categorized patients with CD into good (CD-G), intermediate (CD-I) and poor (CD-P) prognosis groups, according to the history of using biologics and intestinal resection. Microbiota \u03b1-diversity decreased more in CD-P than CD-G and CD-I. Microbiota \u00df-diversity in CD-P differed from that in CD-G and CD-I. Thirteen genera and 10 species showed differential abundance between CD-G and CD-P groups. Escherichia coli (p = 0.001) and species Producta (p = 0.01) and genera Lactobacillus (p = 0.003) and Coprococcus (p = 0.01) consistently showed differences between CD-G and CD-P groups after adjusting for confounding variables. Functional profiling suggested that the microbial catabolic pathways and pathways related to enterobacterial common antigen and lipopolysaccharide biosynthesis were better represented in the CD-P group than in the CD-G group, and E. coli were the top contributors to these pathways. CD prognosis is associated with altered microbiota composition and decreased diversity, and E. coli might be causally involved in CD progression, and may have adapted to live in inflammatory environments.<\/jats:p>","DOI":"10.3390\/jcm9061748","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T06:34:16Z","timestamp":1591684456000},"page":"1748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Differentially Abundant Bacterial Taxa Associated with Prognostic Variables of Crohn\u2019s Disease: Results from the IMPACT Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Soo-kyung","family":"Park","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea"},{"name":"Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea"},{"name":"Inflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-7469","authenticated-orcid":false,"given":"Han-Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea"},{"name":"Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul 03063, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hwan","family":"Choi","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, Korea"},{"name":"Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06973, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, Korea"},{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Myung","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Soo","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Guri Hospital, Guri 11923, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Oh","family":"Kim","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, Korea"},{"name":"Division of Gastroenterology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan 48108, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1946-7896","authenticated-orcid":false,"given":"Sang-Bum","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal medicine, Daejeon St. Mary\u2019s Hospital, The Catholic University of Korea, Daejeon 34943, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Bae","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dankook University College of Medicine, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul 04401, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunho","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan 31151, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk","family":"Yoon","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, Korea"},{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Soo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Guri Hospital, Guri 11923, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chil-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsung","family":"Ahn","sequence":"additional","affiliation":[{"name":"Functional Genome Institute, PDXen Biosystems Inc., Daejeon 34129, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-8884","authenticated-orcid":false,"given":"Hyung-Lae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul 07804, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea"},{"name":"Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea"},{"name":"Inflammatory Bowel Disease Study Group of the Korean Association for the Study of Intestinal Diseases, Seoul 06193, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s 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