{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:06:02Z","timestamp":1790838362067,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004168","name":"University of L\u00fcbeck","doi-asserted-by":"publisher","award":["J01-2020"],"award-info":[{"award-number":["J01-2020"]}],"id":[{"id":"10.13039\/501100004168","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Idiopathic epiretinal membrane (iERM) is a common eye disease, which can be treated by surgical removal of the fibrotic tissue. Morphological outcome is generally evaluated by optical coherence tomography (OCT). Here, we investigate the impact of surgery on hemodynamics of the posterior pole, using OCT angiography (OCTA). Methods: Patients with unilateral iERM and indication for treatment were included. OCT and OCTA images of the posterior pole were obtained preoperatively and 3-months after 23G vitrectomy with membrane peeling. Parameters of interest included full retinal perfusion, choriocapillaris perfusion (CCP), Sattler\u2019s layer perfusion (SLP), and Haller\u2019s layer perfusion, which were evaluated longitudinally and also compared to unaffected fellow eyes. Using these parameters, multiple regression analyses were used to predict visual outcomes. Results: Sixty-three iERM eyes were recruited, which initially showed a significant bigger central retinal thickness (p &lt; 0.001) and total macular volume (TMV) (p &lt; 0.001) compared to fellow eyes, while perfusion parameters were alike. Three months later, treated eyes had a statistically significant thicker subfoveal choroid (p = 0.006) and showed an increase of CCP (p = 0.003), while SLP decreased (p = 0.014). Lower preoperative TMV and higher SLP were associated with better postoperative visual outcome. Conclusion: In this OCTA study, iERM itself does not affect the choroidal circulation. However, preoperative choroidal circulation will be a biomarker to know the influence on the choroidal circulation after ERM surgery and may be considered as a predictor for visual outcome.<\/jats:p>","DOI":"10.3390\/jcm9061768","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T06:34:16Z","timestamp":1591684456000},"page":"1768","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ocular Blood Flow Changes Impact Visual Acuity Gain after Surgical Treatment for Idiopathic Epiretinal Membrane"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-0607","authenticated-orcid":false,"given":"Felix","family":"Rommel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"},{"name":"Laboratory for Angiogenesis &amp; Ocular Cell Transplantation, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max P.","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Laboratory for Angiogenesis &amp; Ocular Cell Transplantation, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A. M.","family":"Sochurek","sequence":"additional","affiliation":[{"name":"Laboratory for Angiogenesis &amp; Ocular Cell Transplantation, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Prasuhn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"},{"name":"Laboratory for Angiogenesis &amp; Ocular Cell Transplantation, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Grisanti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdy","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"},{"name":"Laboratory for Angiogenesis &amp; Ocular Cell Transplantation, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ajo.2015.05.010","article-title":"Lamellar Hole-Associated Epiretinal Proliferation in Comparison to Epiretinal Membranes of Macular Pseudoholes","volume":"160","author":"Compera","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1167\/iovs.13-12817","article-title":"Influence of retinal vessel printings on metamorphopsia and retinal architectural abnormalities in eyes with idiopathic macular epiretinal membrane","volume":"54","author":"Cifariello","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_3","first-page":"36","article-title":"The surgical removal of epiretinal macular membranes (macular puckers)","volume":"173","author":"Machemer","year":"1978","journal-title":"Klin. Monatsbl. Augenheilkd."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/IAE.0000000000001263","article-title":"The Effect of Internal Limiting Membrane Peeling on Idiopathic Epiretinal Membrane Surgery, with a Review of the Literature","volume":"37","author":"Schechet","year":"2017","journal-title":"Retina Phila. Pa"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/aos.12537","article-title":"Predictive factors for postoperative visual acuity in idiopathic epiretinal membrane: A systematic review","volume":"93","author":"Scheerlinck","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.joco.2018.02.001","article-title":"Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults","volume":"30","author":"Rommel","year":"2018","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e1062","DOI":"10.1111\/aos.14140","article-title":"Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography","volume":"97","author":"Siegfried","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s10792-017-0608-1","article-title":"Microvascular changes after vitrectomy with internal limiting membrane peeling: An optical coherence tomography angiography study","volume":"38","author":"Mastropasqua","year":"2018","journal-title":"Int. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/bjophthalmol-2017-311188","article-title":"Macular capillary plexuses after epiretinal membrane surgery: An optical coherence tomography angiography study","volume":"102","author":"Kim","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chen, H., Chi, W., Cai, X., Deng, Y., Jiang, X., Wei, Y., and Zhang, S. (2018). Macular microvasculature features before and after vitrectomy in idiopathic macular epiretinal membrane: An OCT angiography analysis. Eye Lond. Engl.","DOI":"10.1038\/s41433-018-0272-3"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mastropasqua, R., D\u2019Aloisio, R., Viggiano, P., Borrelli, E., Iafigliola, C., Di Nicola, M., Aharrh-Gnama, A., Di Marzio, G., Toto, L., and Mariotti, C. (2019). Early retinal flow changes after vitreoretinal surgery in idiopathic epiretinal membrane using swept source optical coherence tomography angiography. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122067"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Okawa, Y., Maruko, I., Kawai, M., Hasegawa, T., Arakawa, H., and Iida, T. (2019). Foveal structure and vasculature in eyes with idiopathic epiretinal membrane. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214881"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3928\/23258160-20171030-06","article-title":"Quantitative Choriocapillaris Perfusion Before and After Vitrectomy in Idiopathic Epiretinal Membrane by Optical Coherence Tomography Angiography","volume":"48","author":"Yu","year":"2017","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40942-019-0162-2","article-title":"Mapping diurnal variations in choroidal sublayer perfusion in patients with idiopathic epiretinal membrane: An optical coherence tomography angiography study","volume":"5","author":"Rommel","year":"2019","journal-title":"Int. J. Retina Vitr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41598-020-57656-w","article-title":"Choroidoscleral Interface Irregularity Index: A novel optical coherence tomography-based parameter in patients with epiretinal membrane","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00417-018-4053-2","article-title":"Prevalences of segmentation errors and motion artifacts in OCT-angiography differ among retinal diseases","volume":"256","author":"Lauermann","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Early Treatment Diabetic Retinopathy Study Research Group (1991). Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Ophthalmology, 98, 786\u2013806.","DOI":"10.1016\/S0161-6420(13)38012-9"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ajo.2016.12.006","article-title":"Insights Into Epiretinal Membranes: Presence of Ectopic Inner Foveal Layers and a New Optical Coherence Tomography Staging Scheme","volume":"175","author":"Govetto","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajo.2017.10.011","article-title":"Tractional Abnormalities of the Central Foveal Bouquet in Epiretinal Membranes: Clinical Spectrum and Pathophysiological Perspectives","volume":"184","author":"Govetto","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00417-017-3723-9","article-title":"Mapping diurnal changes in choroidal, Haller\u2019s and Sattler\u2019s layer thickness using 3-dimensional 1060-nm optical coherence tomography","volume":"255","author":"Gabriel","year":"2017","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Esmaeelpour, M., Kajic, V., Zabihian, B., Othara, R., Ansari-Shahrezaei, S., Kellner, L., Krebs, I., Nemetz, S., Kraus, M.F., and Hornegger, J. (2014). Choroidal Haller\u2019s and Sattler\u2019s layer thickness measurement using 3-dimensional 1060-nm optical coherence tomography. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099690"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"A Threshold Selection Method from Gray-Level Histograms","volume":"9","author":"Otsu","year":"1979","journal-title":"IEEE Trans. Syst. Man Cybern."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1167\/iovs.17-21417","article-title":"Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography","volume":"58","author":"Rosa","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s41687-017-0023-4","article-title":"Exploring the quality of life issues in people with retinal diseases: A qualitative study","volume":"1","author":"Khadka","year":"2017","journal-title":"J. Patient-Rep. Outcomes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.ajo.2013.01.021","article-title":"Displacement of the retina and its recovery after vitrectomy in idiopathic epiretinal membrane","volume":"155","author":"Nitta","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/IAE.0000000000000768","article-title":"Measurement of Retinal Displacement and Metamorphopsia after Epiretinal Membrane or Macular Hole Surgery","volume":"36","author":"Rodrigues","year":"2016","journal-title":"Retina Phila. Pa"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/IAE.0000000000001972","article-title":"Foveal Avascular Zone Area Analysis Using Optical Coherence Tomography Angiography Before and After Idiopathic Epiretinal Membrane Surgery","volume":"39","author":"Kitagawa","year":"2019","journal-title":"Retina Phila. Pa"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3928\/23258160-20160419-02","article-title":"Focal Nonperfusion of Deep Retinal Capillary Plexus in Eyes With Epiretinal Membranes Revealed by Optical Coherence Tomography Angiography","volume":"47","author":"Lin","year":"2016","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bontzos, G., Kabanarou, S.A., Garnavou-Xirou, C., Gkizis, I., Kontou, E., Triantafyllou, D., and Xirou, T. (2020). Segmentation errors and motion artifacts in OCT-A associated with epiretinal membranes. Can. J. Ophthalmol. J. Can. Ophtalmol.","DOI":"10.1016\/j.jcjo.2019.12.007"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ajo.2010.05.037","article-title":"Long-term temporal changes of macular thickness and visual outcome after vitrectomy for idiopathic epiretinal membrane","volume":"150","author":"Kim","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/IAE.0000000000000350","article-title":"Choroidal thickness measured with swept source optical coherence tomography before and after vitrectomy with internal limiting membrane peeling for idiopathic epiretinal membranes","volume":"35","author":"Michalewska","year":"2015","journal-title":"Retina Phila. Pa"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.1111\/aos.13097","article-title":"Changes in choroidal thickness after vitrectomy for epiretinal membrane combined with vitreomacular traction","volume":"95","author":"Kang","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1167\/iovs.12-10464","article-title":"Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: Enhanced depth imaging optical coherence tomography study","volume":"53","author":"Kim","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00417-008-0980-7","article-title":"Physiology of vitreous surgery","volume":"247","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1167\/iovs.13-13839","article-title":"Cyclic stretch and hypertension increase retinal succinate: Potential mechanisms for exacerbation of ocular neovascularization by mechanical stress","volume":"55","author":"Kinoshita","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/6\/1768\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:36:26Z","timestamp":1760175386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/6\/1768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,7]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["jcm9061768"],"URL":"https:\/\/doi.org\/10.3390\/jcm9061768","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,7]]}}}