{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:42:27Z","timestamp":1780418547448,"version":"3.54.1"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["NIHR-CS-012-009"],"award-info":[{"award-number":["NIHR-CS-012-009"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["IS-BRC-1215-20007"],"award-info":[{"award-number":["IS-BRC-1215-20007"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["NF-SI-0513-10076"],"award-info":[{"award-number":["NF-SI-0513-10076"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M018431\/1"],"award-info":[{"award-number":["MR\/M018431\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A barrier to Lynch syndrome testing is the need for prior genetic counselling, a resource demanding process for both patients and healthcare services. We explored the impact of gynaecologist led Lynch syndrome testing in women with endometrial cancer. Women were approached before surgery, on the day of surgery or during routine follow up. Lynch syndrome testing was offered irrespective of age, family history or tumour characteristics. Women\u2019s reasons for being tested were explored using the Motivations and Concerns for GeNEtic Testing (MACGNET) instrument. The short form State-Trait Anxiety Inventory (STAI-6) was used to measure anxiety levels. Only 3\/305 women declined Lynch syndrome testing. In total, 175\/220 completed MACGNET and STAI-6 psychological instruments. The consent process took an average of 7 min 36 s (SD 5 min 16 s) to complete. The point of care at which consent was taken (before, day of surgery, during follow up) did not influence motivation for Lynch syndrome testing. Anxiety levels were significantly lower when women were consented during follow up (mean reversed STAI-6 score 32 vs. 42, p = 0.001). Anxiety levels were not affected by familial cancer history (p = 0.41). Gynaecologist led Lynch syndrome testing is feasible and may even be desirable in endometrial cancer, especially when offered during routine follow up.<\/jats:p>","DOI":"10.3390\/jcm9061842","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:50:49Z","timestamp":1592268649000},"page":"1842","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Feasibility of Gynaecologist Led Lynch Syndrome Testing in Women with Endometrial Cancer"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-3257","authenticated-orcid":false,"given":"Neil A. J.","family":"Ryan","sequence":"first","affiliation":[{"name":"Division of Evolution and Genomic Medicine, University of Manchester, St Mary\u2019s Hospital, Manchester M13 9WL, UK"},{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary\u2019s Hospital, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-7272","authenticated-orcid":false,"given":"Louise","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Nightingale and Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"NIHR Greater Manchester Patient Safety Translational Research Centre, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4966-2414","authenticated-orcid":false,"given":"Katie","family":"Stocking","sequence":"additional","affiliation":[{"name":"Centre for Biostatistics, Faculty of Biology, Medicine and Health, University of Manchester, St Mary\u2019s Hospital, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-5784","authenticated-orcid":false,"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"Division of Evolution and Genomic Medicine, University of Manchester, St Mary\u2019s Hospital, Manchester M13 9WL, UK"},{"name":"Nightingale and Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-8630","authenticated-orcid":false,"given":"Emma J.","family":"Crosbie","sequence":"additional","affiliation":[{"name":"Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary\u2019s Hospital, Manchester M13 9WL, UK"},{"name":"Division of Gynaecology, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(15)00130-0","article-title":"Endometrial cancer","volume":"387","author":"Morice","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1001\/jamaoncol.2017.0619","article-title":"Association of Mismatch Repair Mutation with Age at Cancer Onset in Lynch Syndrome: Implications for Stratified Surveillance Strategies","volume":"3","author":"Ryan","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/gutjnl-2015-309675","article-title":"Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: First report from the prospective Lynch syndrome database","volume":"66","author":"Moller","year":"2017","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/01.AOG.0000154885.44002.ae","article-title":"Gynecologic Cancer as a \u201cSentinel Cancer\u201d for Women with Hereditary Nonpolyposis Colorectal Cancer Syndrome","volume":"105","author":"Lu","year":"2005","journal-title":"Obs. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fimmu.2019.03023","article-title":"Distinct Immunological Landscapes Characterize Inherited and Sporadic Mismatch Repair Deficient Endometrial Cancer","volume":"10","author":"Ramchander","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0140-6736(11)61049-0","article-title":"Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial","volume":"378","author":"Burn","year":"2011","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10689-016-9893-5","article-title":"Genetic counseling and cascade genetic testing in Lynch syndrome","volume":"15","author":"Hampel","year":"2016","journal-title":"Fam. Cancer"},{"key":"ref_8","first-page":"1","article-title":"The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome","volume":"76","author":"Crosbie","year":"2019","journal-title":"Genet. Med."},{"key":"ref_9","first-page":"181","article-title":"The proportion of endometrial cancers associated with Lynch syndrome: A systematic review of the literature and meta-analysis","volume":"15","author":"Ryan","year":"2019","journal-title":"Genet. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Snowsill, T.M., Ryan, N.A.J., Crosbie, E.J., Frayling, I.M., Evans, D.G., and Hyde, C.J. (2019). Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221419"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1399-0004.2007.00779.x","article-title":"Genetic counselling and consent for tumour testing in HNPCC","volume":"71","author":"Gaff","year":"2007","journal-title":"Clin. Genet."},{"key":"ref_12","first-page":"2167","article-title":"The Proportion of Endometrial Tumours Associated with Lynch Syndrome: A prospective cross-sectional study of unselected screening of endometrial cancer for Lynch syndrome (PETALS study)","volume":"21","author":"Ryan","year":"2000","journal-title":"PLoS Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1136\/jmg.2003.012526","article-title":"Comparison of motivations and concerns for genetic testing in hereditary colorectal and breast cancer syndromes","volume":"41","author":"Stoffel","year":"2004","journal-title":"J. Med. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.2044-8260.1992.tb00997.x","article-title":"The development of a six-item short-form of the state scale of the Spielberger State\u2014Trait Anxiety Inventory (STAI)","volume":"31","author":"Marteau","year":"1992","journal-title":"Br. J. Clin. Psychol."},{"key":"ref_15","first-page":"1","article-title":"Methods for Computing Missing Item Response in Psychometric Scale Construction","volume":"5","author":"Siddiqui","year":"2015","journal-title":"Am. J. Biostat."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Motulsky, H.J., and Brown, R.E. (2006). Detecting outliers when fitting data with nonlinear regression\u2014A new method based on robust nonlinear regression and the false discovery rate. BMC Bioinform., 7.","DOI":"10.1186\/1471-2105-7-123"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1200\/JCO.2015.63.9518","article-title":"Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers from GOG210: An NRG Oncology and Gynecologic Oncology Group Study","volume":"33","author":"Goodfellow","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1200\/JCO.2013.51.2129","article-title":"Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients with Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for Population-Level Germline Mismatch Repair Gene Mutation Testing","volume":"32","author":"Buchanan","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/jmg.38.7.461","article-title":"Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinoma","volume":"38","author":"Chadwick","year":"2001","journal-title":"J. Med. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Scollon, S., Bergstrom, K., Kerstein, R.A., Wang, T., Hilsenbeck, S.G., Ramamurthy, U., Gibbs, R.A., Eng, C.M., Chintagumpala, M.M., and Berg, S.L. (2014). Obtaining informed consent for clinical tumor and germline exome sequencing of newly diagnosed childhood cancer patients. Genome Med., 6.","DOI":"10.1186\/s13073-014-0069-3"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ygyno.2014.06.009","article-title":"Consequences of universal MSI\/IHC in screening ENDOMETRIAL cancer patients for Lynch syndrome","volume":"134","author":"Batte","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1007\/s10620-014-3234-z","article-title":"Selective Versus Universal Screening for Lynch Syndrome: A Six-Year Clinical Experience","volume":"60","author":"Kidambi","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1136\/bmj.320.7244.1252","article-title":"Multicentre randomised control trial comparing real time teledermatology with conventional outpatient dermatological care: Societal cost-benefit analysis","volume":"320","author":"Wootton","year":"2000","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Snowsill, T.M., Ryan, N.A.J., and Crosbie, E.J. (2020). Cost-Effectiveness of the Manchester Approach to Identifying Lynch Syndrome in Women with Endometrial Cancer. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061664"},{"key":"ref_25","first-page":"881","article-title":"BRCA1\/2 testing in newly diagnosed breast and ovarian cancer patients without prior genetic counselling: The DNA-BONus study","volume":"24","author":"Bjorvatn","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0277-9536(01)00133-2","article-title":"What is the impact of genetic counselling in women at increased risk of developing hereditary breast cancer? A meta-analytic review","volume":"54","author":"Meiser","year":"2002","journal-title":"Soc. Sci. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/sj.bjc.6690078","article-title":"The impact of genetic counselling about breast cancer risk on women\u2019s risk perceptions and levels of distress","volume":"79","author":"Cull","year":"1999","journal-title":"BR. J. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/jnci\/92.16.1345","article-title":"Randomized Trial of a Specialist Genetic Assessment Service for Familial Breast Cancer","volume":"92","author":"Brain","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/sj.bjc.6690139","article-title":"The impact of genetic counselling on risk perception and mental health in women with a family history of breast cancer","volume":"79","author":"Watson","year":"1999","journal-title":"Br. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/jnci\/87.4.286","article-title":"Effects of Individualized Breast Cancer Risk Counseling: A Randomized Trial","volume":"87","author":"Lerman","year":"1995","journal-title":"J. Natl. 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