{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:52:01Z","timestamp":1791089521442,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","award":["Friends For Life"],"award-info":[{"award-number":["Friends For Life"]}],"id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>People with cancer who undergo allogeneic hematological stem cell transplant (allo-HSCT) experience significant deconditioning that can compromise quality of life. Exercise has shown to be beneficial before or after allo-HSCT; however, little is known about exercise therapy delivered across the continuum of care. We conducted a feasibility randomized controlled trial of exercise delivered prior to admission, during the inpatient stay, and after discharge versus control in people with planned allo-HSCT. Feasibility was assessed via recruitment and retention rates, the incidence of adverse events, and adherence to the exercise prescription. Estimates of efficacy were measured at baseline, one week prior to hospital admission, and 100 days and one year after transplant. The recruitment and retention rates were 20% and 33%, respectively. One serious adverse event occurred during the baseline six-minute walk test that precluded participation in the study and no adverse events were associated with the intervention. From baseline to pre-transplant, the intervention group improved six-minute walk test distances by 45 m (95% CI: \u221218.0 to 108.7)\u2014a finding that warrants further investigation with an adequately powered trial. Our study contributes important feasibility considerations and pilot data for future exercise intervention research in allo-HSCT recipients.<\/jats:p>","DOI":"10.3390\/jcm9061854","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:50:49Z","timestamp":1592268649000},"page":"1854","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial"],"prefix":"10.3390","volume":"9","author":[{"given":"Daniel","family":"Santa Mina","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada"},{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"},{"name":"Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne B.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"},{"name":"Toronto Rehabilitation Institute, University Health Network, Toronto, ON M5G 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada"},{"name":"Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Au","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada"},{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarna","family":"Camacho P\u00e9rez","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada"},{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Franzese","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabbir M. H.","family":"Alibhai","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"},{"name":"Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8514","authenticated-orcid":false,"given":"Jennifer M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"},{"name":"Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada"},{"name":"Toronto Rehabilitation Institute, University Health Network, Toronto, ON M5G 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada"},{"name":"Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,14]]},"reference":[{"key":"ref_1","unstructured":"Canadian Cancer Statistics Advisory Committee (2019). 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