{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:39:01Z","timestamp":1792240741992,"version":"4.4.0"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (\u226415-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (\u00b12.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3\u201344.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0\u201332), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood.<\/jats:p>","DOI":"10.3390\/jcm9072097","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:49:11Z","timestamp":1594028951000},"page":"2097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Child\u2013Adult Transition in Sarcoidosis: A Series of 52 Patients"],"prefix":"10.3390","volume":"9","author":[{"given":"Simon","family":"Chauveau","sequence":"first","affiliation":[{"name":"AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France"},{"name":"Inserm UMR_1272, Laboratory of Hypoxia &amp; Lung Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-5569","authenticated-orcid":false,"given":"Florence","family":"Jeny","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France"},{"name":"Inserm UMR_1272, Laboratory of Hypoxia &amp; Lung Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Emeline","family":"Montagne","sequence":"additional","affiliation":[{"name":"AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Armand Trousseau Hospital, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Abou Taam","sequence":"additional","affiliation":[{"name":"AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Necker Enfants Malades Hospital, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Houdouin","sequence":"additional","affiliation":[{"name":"AP-HP Pediatric Pulmonology Department, Robert Debr\u00e9 Hospital, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Meinzer","sequence":"additional","affiliation":[{"name":"AP-HP Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, National Referee Center for Rare Pediatric Inflammatory Rheumatisms and Systemic Auto-Immune Diseases RAISE, Robert Debr\u00e9 University Hospital, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Delacourt","sequence":"additional","affiliation":[{"name":"AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Necker Enfants Malades Hospital, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-1039","authenticated-orcid":false,"given":"Ralph","family":"Epaud","sequence":"additional","affiliation":[{"name":"Pediatric Department and Reference Center for Rare Lung Diseases (RespiRare), Centre Hospitalier Intercommunal de Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"University Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Cohen Aubart","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Interne 2, French National Reference Center for rare Systemic diseases, 75013-Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chapelon-Abric","sequence":"additional","affiliation":[{"name":"AP-HP Department of Internal Medicine and Clinical Immunology, La Piti\u00e9 Salp\u00e9tri\u00e8re Hospital, AP-HP, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Isra\u00ebl-Biet","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, HEGP Hospital, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Juvin","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, HEGP Hospital, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Dossier","sequence":"additional","affiliation":[{"name":"AP-HP Department of Internal Medicine, Bichat Hospital, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Bodaghi","sequence":"additional","affiliation":[{"name":"AP-HP Department of Ophtalmology, La Piti\u00e9 Salp\u00e9tri\u00e8re Hospital, IHU FOReSIGHT, Sorbonne Universit\u00e9, 75013 Paris, France"},{"name":"AP-HP Department of Ophtalmology, Avicenne Hospital, IHU FOReSIGHT, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Pr\u00e9vot","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Larrey University Hospital, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Naccache","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, Tenon Hospital, 75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-6947","authenticated-orcid":false,"given":"Sarah","family":"Mattioni","sequence":"additional","affiliation":[{"name":"AP-HP Department of Internal Medicine, Tenon Hospital, 75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Deschildre","sequence":"additional","affiliation":[{"name":"Paediatric Pulmonology and Allergy Unit, CHU Lille, Universit\u00e9 de lille, H\u00f4pital Jeanne de Flandre, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Brouard","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Department, Caen University Hospital, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellatif","family":"Tazi","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, Saint Louis Hospital, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderich","family":"Meckenstock","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Diseases Department, Versailles Hospital, 78150 Le Chesnay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Didier","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France"},{"name":"Inserm UMR_1272, Laboratory of Hypoxia &amp; Lung Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Haroche","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital de la Piti\u00e9-Salp\u00eatri\u00e8re, Service de M\u00e9decine Interne 2, French National Reference Center for rare Systemic diseases, 75013-Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Clement","sequence":"additional","affiliation":[{"name":"AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Armand Trousseau Hospital, 75012 Paris, France"},{"name":"Inserm UMR-S933, Childhood Genetic Disorders, Sorbonne Universit\u00e9, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Bernaudin","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France"},{"name":"Inserm UMR_1272, Laboratory of Hypoxia &amp; Lung Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilario","family":"Nunes","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France"},{"name":"Inserm UMR_1272, Laboratory of Hypoxia &amp; Lung Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valeyre","sequence":"additional","affiliation":[{"name":"AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France"},{"name":"Inserm UMR_1272, Laboratory of Hypoxia &amp; Lung Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-7975","authenticated-orcid":false,"given":"Nadia","family":"Nathan","sequence":"additional","affiliation":[{"name":"AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Armand Trousseau Hospital, 75012 Paris, France"},{"name":"Inserm UMR-S933, Childhood Genetic Disorders, Sorbonne Universit\u00e9, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the French Sarcoidosis Group (GSF)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1034\/j.1399-3003.1999.14d02.x","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for Sarcoidosis and Other Granulomatous Disorders","volume":"14","author":"Costabel","year":"1999","journal-title":"Eur. Respir. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1056\/NEJMra071714","article-title":"Sarcoidosis","volume":"357","author":"Iannuzzi","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_3","first-page":"1052","article-title":"Autoimmune Big Data Study Group Geoepidemiological big data approach to sarcoidosis: Geographical and ethnic determinants","volume":"37","author":"Kostov","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.rmed.2014.12.012","article-title":"Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan","volume":"109","author":"Sawahata","year":"2015","journal-title":"Respir. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Duchemann, B., Annesi-Maesano, I., de Naurois, C.J., Sanyal, S., Brillet, P.-Y., Brauner, M., Kambouchner, M., Huynh, S., Naccache, J.M., and Borie, R. (2017). Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris. Eur. Respir. J., 50.","DOI":"10.1183\/13993003.02419-2016"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/thoraxjnl-2015-206825","article-title":"Lung sarcoidosis in children: Update on disease expression and management","volume":"70","author":"Nathan","year":"2015","journal-title":"Thorax"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1164\/ajrccm.164.10.2104046","article-title":"Clinical characteristics of patients in a case control study of sarcoidosis","volume":"164","author":"Baughman","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_8","first-page":"149","article-title":"Sarcoidosis in children","volume":"30","author":"Shetty","year":"2000","journal-title":"Curr. Probl. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1546-0096-6-16","article-title":"Childhood sarcoidosis: A rare but fascinating disorder","volume":"6","author":"Shetty","year":"2008","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1651-2227.2004.tb00670.x","article-title":"Childhood sarcoidosis in Denmark 1979-1994: Incidence, clinical features and laboratory results at presentation in 48 children","volume":"93","author":"Hoffmann","year":"2004","journal-title":"Acta Paediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.rmed.2008.12.007","article-title":"Health-related quality of life in adult survivors of childhood sarcoidosis","volume":"103","author":"Milman","year":"2009","journal-title":"Respir. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s10067-015-2870-9","article-title":"Childhood sarcoidosis: Louisiana experience","volume":"35","author":"Gedalia","year":"2016","journal-title":"Clin. Rheumatol."},{"key":"ref_13","first-page":"53","article-title":"Paediatric sarcoidosis","volume":"29","author":"Nathan","year":"2019","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-7-40","article-title":"A national internet-linked based database for pediatric interstitial lung diseases: The French network","volume":"7","author":"Nathan","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S2213-2600(13)70276-5","article-title":"An integrated clinicoradiological staging system for pulmonary sarcoidosis: A case-cohort study","volume":"2","author":"Walsh","year":"2014","journal-title":"Lancet Respir. Med."},{"key":"ref_16","first-page":"257","article-title":"Reliability of bronchoalveolar lavage in the routine clinical assessment of patients with sarcoidosis. A retrospective analysis","volume":"44","author":"Marruchella","year":"2002","journal-title":"Panminerva Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e7595","DOI":"10.1097\/MD.0000000000007595","article-title":"Multidisciplinary approach and long-term follow-up in a series of 640 consecutive patients with sarcoidosis: Cohort study of a 40-year clinical experience at a tertiary referral center in Barcelona, Spain","volume":"96","author":"Villalba","year":"2017","journal-title":"Medicine"},{"key":"ref_18","first-page":"52","article-title":"The late follow-up of chronic sarcoid patients previously treated with corticosteroids","volume":"15","author":"Rizzato","year":"1998","journal-title":"Sarcoidosis Vasc. Diffus. Lung Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1164\/rccm.201305-0923ST","article-title":"An Official American Thoracic Society Clinical Practice Guideline: Classification, Evaluation, and Management of Childhood Interstitial Lung Disease in Infancy","volume":"188","author":"Kurland","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nathan, N., Borensztajn, K., and Clement, A. (2018). Genetic causes and clinical management of pediatric interstitial lung diseases. Curr. Opin. Pulm. Med.","DOI":"10.1097\/MCP.0000000000000471"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/thoraxjnl-2015-207349","article-title":"European protocols for the diagnosis and initial treatment of interstitial lung disease in children","volume":"70","author":"Bush","year":"2015","journal-title":"Thorax"},{"key":"ref_22","first-page":"56","article-title":"Defining the clinical outcome status (COS) in sarcoidosis: Results of WASOG Task Force","volume":"28","author":"Baughman","year":"2011","journal-title":"Sarcoidosis Vasc. Diffus. Lung Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.rmed.2017.09.003","article-title":"Toxicity risk from glucocorticoids in sarcoidosis patients","volume":"132","author":"Khan","year":"2017","journal-title":"Respir. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S2213-2600(18)30064-X","article-title":"Pulmonary sarcoidosis","volume":"6","author":"Spagnolo","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00467-018-4149-2","article-title":"Five-year outcome of children with idiopathic nephrotic syndrome: The NEPHROVIR population-based cohort study","volume":"34","author":"Dossier","year":"2019","journal-title":"Pediatr. Nephrol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-0034-1387817","article-title":"Efficacy and tolerability of methylprednisolone pulse therapy in childhood epilepsies other than infantile spasms","volume":"45","author":"Bast","year":"2014","journal-title":"Neuropediatrics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.rmed.2015.01.019","article-title":"The effect of corticosteroids on quality of life in a sarcoidosis clinic: The results of a propensity analysis","volume":"109","author":"Judson","year":"2015","journal-title":"Respir. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1164\/rccm.200703-393OC","article-title":"Diffuse lung disease in young children: Application of a novel classification scheme","volume":"176","author":"Deutsch","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/his.12185","article-title":"Diffuse lung disease in infancy and childhood: Expanding the chILD classification","volume":"63","author":"Rice","year":"2013","journal-title":"Histopathology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.prrv.2011.01.002","article-title":"Paediatric interstitial lung disease: Classification and definitions","volume":"12","author":"Dishop","year":"2011","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/ppul.22956","article-title":"Sarcoidosis in children: HRCT findings and correlation with pulmonary function tests","volume":"49","author":"Sileo","year":"2014","journal-title":"Pediatr. Pulmonol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0002-9343(85)90463-2","article-title":"Course and prognosis of sarcoidosis in a nonreferral setting. Analysis of 86 patients observed for 10 years","volume":"78","author":"Reich","year":"1985","journal-title":"Am. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1183\/09031936.00187410","article-title":"Stage IV sarcoidosis: Comparison of survival with the general population and causes of death","volume":"38","author":"Nardi","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chest.2017.07.008","article-title":"Predictors of Mortality in Pulmonary Sarcoidosis","volume":"153","author":"Kirkil","year":"2018","journal-title":"Chest"},{"key":"ref_35","unstructured":"(2020, May 20). Anthropom\u00e9trie, Adultes: Tableaux de Distribution ENNS. Available online: https:\/\/www.santepubliquefrance.fr\/determinants-de-sante\/nutrition-et-activite-physique\/articles\/enns-etude-nationale-nutrition-sante\/anthropometrie-adultes-tableaux-de-distribution-enns."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/7\/2097\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:47:02Z","timestamp":1760176022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/7\/2097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,3]]},"references-count":35,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["jcm9072097"],"URL":"https:\/\/doi.org\/10.3390\/jcm9072097","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,3]]}}}