{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:20:13Z","timestamp":1767842413574,"version":"3.49.0"},"reference-count":61,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Binge drinking and other forms of ethanol abuse are, when present, a serious problem in preteens and adolescents worldwide. Aim: The present study has analyzed the trend in alcohol-related intoxications requiring the hospitalization of children, adolescents and young adults aged less than 21 years in Slovenia in the 1999\u20132018 period. Methods: We performed a retrospective study on patients discharged after hospitalizations due to mental and behavioral disorders due to acute alcohol intoxication (MBDAAI) or hospitalizations due to the toxic effects of alcohol (TEA We considered three groups: children (aged 10\u201314), adolescents (aged 15\u201319) and young adults (20\u201321 years old). Hospitalization rates and time trends were analyzed using joinpoint regression to obtain the annually calculated age- and sex-specific rates and the annual percentage of change (APC). Results: Considering a total of 2912 MBDAAI-hospitalizations, 15\u201319-year-old subjects showed a significantly higher hospitalization rate compared to the immediately younger and older age groups and a significant increase in hospitalization rates in the period 1999\u20132011, followed by a significant decrease. Considering 1143 TEA-hospitalizations, we observed a continuous decrease in the hospitalization rates for children and young adults and, conversely, a continuous even if less than significant increase for adolescents aged 15\u201319. Conclusions: Alcohol consumption in Slovenian children and adolescents is a highly important health concern. Special attention to public health problem of severe alcohol abuse requiring hospitalization in children and adolescents is needed, especially with possible crisis of SARS-CoV-2\/Covid-19 situation.<\/jats:p>","DOI":"10.3390\/jcm9072122","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:49:11Z","timestamp":1594028951000},"page":"2122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Trends of Hospitalization for Acute Alcohol Intoxication in Slovenian Children and Adolescents with and without Dual Disorder. Implications for a Correct Intervention"],"prefix":"10.3390","volume":"9","author":[{"given":"Mercedes","family":"Lovrecic","sequence":"first","affiliation":[{"name":"National Institute of Public Health, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Lovrecic","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateja","family":"Rok Simon","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ales","family":"Korosec","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-3524","authenticated-orcid":false,"given":"Filippo","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"School of Psychiatry, University of Pisa, 56100 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Maremmani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, North-Western Tuscany Local Health Unit, Tuscany NHS, Versilia Zone, 55049 Viareggio, Italy"},{"name":"Association for the Application of Neuroscientific Knowledge to Social Aims (AU-CNS), 55045 Pietrasanta, Italy"},{"name":"PISA-School of Experimental and Clinical Psychiatry, 56100 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-0576","authenticated-orcid":false,"given":"Icro","family":"Maremmani","sequence":"additional","affiliation":[{"name":"Association for the Application of Neuroscientific Knowledge to Social Aims (AU-CNS), 55045 Pietrasanta, Italy"},{"name":"Vincent P. Dole Dual Disorder Unit, 2nd Psychiatric Unit, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, Italy"},{"name":"G. De Lisio Institute of Behavioral Sciences, 56100 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/add.13757","article-title":"The relationship between different dimensions of alcohol use and the burden of disease-an update","volume":"112","author":"Rehm","year":"2017","journal-title":"Addiction"},{"key":"ref_2","unstructured":"WHO (2007). International Classification of Diseases and Related Health Problems, 10th Revision, WHO."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/09687630600902477","article-title":"Alcohol in Europe\u2014Public Health Perspective: Report summary","volume":"13","author":"Anderson","year":"2006","journal-title":"Drugs Educ. Prev. Policy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/bjc.2014.579","article-title":"Alcohol consumption and site-specific cancer risk: A comprehensive dose-response meta-analysis","volume":"112","author":"Bagnardi","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_5","unstructured":"WHO (2018). Global status report on alcohol and health, WHO."},{"key":"ref_6","unstructured":"EC. WHO Regional Office for Europe (2018). Alcohol Consumption, Harm and Policy Response Fact Sheets for 30 European Countries, WHO."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rehm, J., Cr\u00e9pault, J.-F., Hasan, O.S.M., Lachenmeier, D.W., Room, R., and Sornpaisarn, B. (2019). Regulatory Policies for Alcohol, other Psychoactive Substances and Addictive Behaviours: The Role of Level of Use and Potency. A Systematic Review. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16193749"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11065-007-9038-6","article-title":"Alcohol: Effects on neurobehavioral functions and the brain","volume":"17","year":"2007","journal-title":"Neuropsychol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e20191357","DOI":"10.1542\/peds.2019-1357","article-title":"Alcohol Use by Youth","volume":"144","author":"Ryan","year":"2019","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tics.2004.12.005","article-title":"Cognitive and affective development in adolescence","volume":"9","author":"Steinberg","year":"2005","journal-title":"Trends Cogn. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1196\/annals.1440.010","article-title":"The adolescent brain","volume":"1124","author":"Casey","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/add.13785","article-title":"Modifiable parenting factors associated with adolescent alcohol misuse: A systematic review and meta-analysis of longitudinal studies","volume":"112","author":"Yap","year":"2017","journal-title":"Addiction"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1037\/a0027892","article-title":"Abnormal affective decision making revealed in adolescent binge drinkers using a functional magnetic resonance imaging study","volume":"27","author":"Xiao","year":"2013","journal-title":"Psychol. Addict. Behav."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/j.1360-0443.2004.00918.x","article-title":"Drinking patterns in mid-adolescence and psychosocial outcomes in late adolescence and early adulthood","volume":"99","author":"Wells","year":"2004","journal-title":"Addiction"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1136\/jech.2005.038117","article-title":"Adult outcomes of binge drinking in adolescence: Findings from a UK national birth cohort","volume":"61","author":"Viner","year":"2007","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1530-0277.2007.00602.x","article-title":"Prefrontal cortex volumes in adolescents with alcohol use disorders: Unique gender effects","volume":"32","author":"Medina","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.15288\/jsad.2019.80.594","article-title":"Sex Differences in the Effect of Nucleus Accumbens Volume on Adolescent Drinking: The Mediating Role of Sensation Seeking in the NCANDA Sample","volume":"80","author":"Morales","year":"2019","journal-title":"J. Stud. Alcohol. Drugs"},{"key":"ref_18","unstructured":"WHO (2020, January 06). Total Alcohol per Capita Consumption (15+ Years, in Litres of Pure Alcohol). Available online: https:\/\/www.who.int\/gho\/alcohol\/alcohol_011.png?ua=011."},{"key":"ref_19","unstructured":"WHO (2020, January 06). Age-Standardized Death Rates (15+) for Liver Cirrhosis per 100,000 Population. Available online: https:\/\/www.who.int\/data\/gho\/data\/indicators\/indicator-details\/GHO\/liver-cirrhosis-age-standardized-death-rates-(15-)-per-100-000-populatio."},{"key":"ref_20","first-page":"51","article-title":"Epidemiolo\u0161ki pogled na porabo alkohola in odvisnost od alkohola v Sloveniji","volume":"2","author":"Lovrecic","year":"2018","journal-title":"Javno Zdr."},{"key":"ref_21","unstructured":"Kraus, L., Guttormsson, U., Leifman, H., Arpa, S., Molinaro, S., Monshouwer, K., Vicente, J., Arnarsson, \u00c1.M., Balakireva, O., and Bye, E.K. (2015). ESPAD Report 2015: Results from the European School Survey Project on Alcohol and Other Drugs, Publications Office of the European Union. Available online: http:\/\/www.espad.org\/report\/home."},{"key":"ref_22","unstructured":"Inchley, J., Currie, D., Young, T., Samdal, O., Torsheim, T., Augustson, L., Mathison, F., Aleman-Diaz, A., Molcho, M., and Weber, M. (2016). Growing up Unequal. HBSC 2016 Study (2013\/2014 Survey), WHO Regional Office for Europe."},{"key":"ref_23","unstructured":"Currie, D., Zanotti, C., Morgan, A., Currie, D., de Looze, M., Roberts, C., Samdal, O., Smith, O.R.F., and Barnekow, V. (2012). Social Determinants of Health and Well-Being among Young People. Health Behaviour in School-Aged Children (HBSC) Study: International Report from the 2009\/2010 Survey, WHO Regional Office for Europe."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s00103-010-1114-z","article-title":"Alkoholintoxikierte Kinder und Jugendliche in der Notfallversorgung Hamburger Krankenh\u00e4user (Acute ethanol intoxication among children and adolescents in Hamburg, Germany)","volume":"53","author":"Stolle","year":"2010","journal-title":"Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00431-011-1394-9","article-title":"Adolescent alcohol intoxication in Dutch hospital centers of pediatrics: Characteristics and gender differences","volume":"170","author":"Bouthoorn","year":"2011","journal-title":"Eur. J. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3325\/cmj.2009.50.151","article-title":"Alcohol intoxication in pediatric age: Ten-year retrospective study","volume":"50","author":"Bitunjac","year":"2009","journal-title":"Croat. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/14659891.2019.1664665","article-title":"Visits of adolescents for acute alcohol intoxication to emergency departments in Northern Italy: Natives and non-natives","volume":"25","author":"Pavarin","year":"2020","journal-title":"J. Subst. Use"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3109\/10826081003682859","article-title":"Contributing Factors in Self-Poisoning Leading to Hospital Admission in Adolescents in Northern Finland","volume":"45","author":"Liisanantti","year":"2010","journal-title":"Subst. Use Misuse"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1515\/IJAMH.2005.17.3.259","article-title":"Suicide attempts among adolescents in northeastern Slovenia: A 25 year report","volume":"17","author":"Turcin","year":"2005","journal-title":"Int. J. Adolesc. Med. Health"},{"key":"ref_30","unstructured":"Donaldson, L. (2020, June 10). Guidance on the Consumption of Alcohol by Children and Young People, Available online: https:\/\/webarchive.nationalarchives.gov.uk\/20130104153257\/http:\/\/www.dh.gov.uk\/prod_consum_dh\/groups\/dh_digitalassets\/documents\/digitalasset\/dh_110256.pdf."},{"key":"ref_31","unstructured":"Slovenia Government (2003). Restrictions on the Use of Alcohol, Act. Zakon o omejevanju porabe alkohola (ZOPA). Uradni list RS, \u0161t; 15\/03 in 27\/17."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/S2215-0366(17)30327-9","article-title":"Architecture and functioning of child and adolescent mental health services: A reply from Slovenia","volume":"4","author":"Radobuljac","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"ref_33","unstructured":"Slovenia Government (2018). Mental Health Act. Zakon o du\u0161evnem zdravju (ZDZdr), Uradni list RS, \u0161t. 77\/08, 46\/15- odl. US in 44\/19 odl. US."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/0009922810388509","article-title":"Alcohol intoxication among Dutch adolescents: Acute medical complications in the years 2000-2010","volume":"50","author":"Bouthoorn","year":"2011","journal-title":"Clin. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pmedr.2015.12.009","article-title":"Effectiveness of a drinking-motive-tailored emergency-room intervention among adolescents admitted to hospital due to acute alcohol intoxication\u2014A randomized controlled trial","volume":"3","author":"Wurdak","year":"2016","journal-title":"Prev. Med. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1753-2000-3-18","article-title":"Alcohol intoxication and mental health among adolescents\u2014A population review of 8983 young people, 13\u201319 years in North-Trondelag, Norway: The Young-HUNT Study","volume":"3","author":"Strandheim","year":"2009","journal-title":"Child Adolesc. Psychiatry Ment Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"366","DOI":"10.15288\/jsad.2010.71.366","article-title":"Adolescent alcohol intoxication in the Dutch hospital Departments of Pediatrics","volume":"71","author":"Lely","year":"2010","journal-title":"J. Stud. Alcohol. Drugs"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jadohealth.2010.06.001","article-title":"Adolescent alcohol intoxication in the Dutch hospital departments of pediatrics: A 2-year comparison study","volume":"48","author":"Bouthoorn","year":"2011","journal-title":"J. Adolesc. Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/alcalc\/agv072","article-title":"Prediction of Long-Term Outcomes in Young Adults with a History of Adolescent Alcohol-Related Hospitalization","volume":"51","author":"Gross","year":"2016","journal-title":"Alcohol. Alcohol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.drugalcdep.2016.02.037","article-title":"Long-term outcomes after adolescent in-patient treatment due to alcohol intoxication: A control group study","volume":"162","author":"Gross","year":"2016","journal-title":"Drug Alcohol. Depend."},{"key":"ref_41","unstructured":"WHO (2019). Alcohol Consumption, Harm and Policy Responses in 30 European Countries in 2016, WHO."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00006565-200010000-00003","article-title":"Alcohol and injury in adolescents","volume":"16","author":"Porter","year":"2000","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"29S","DOI":"10.1097\/01.ALC.0000127412.69258.EE","article-title":"Suicidal Behaviors and Alcohol Use Among Adolescents: A Developmental Psychopathology Perspective","volume":"28","author":"Windle","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_44","unstructured":"IARC (2010). Alcohol consumption and ethyl carbamate. IARC Monogr. Eval. Carcinog. Risks Hum., 96, 1\u20131383."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/add.13627","article-title":"Alcohol\u2019s contribution to cancer is underestimated for exactly the same reason that its contribution to cardioprotection is overestimated","volume":"112","author":"Stockwell","year":"2016","journal-title":"Addiction"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1054-139X(00)00169-5","article-title":"Adolescent substance use and sexual risk-taking behavior","volume":"28","author":"Tapert","year":"2001","journal-title":"J. Adolesc. Health"},{"key":"ref_47","first-page":"27","article-title":"Unreported double frequency of heroin addicts visiting psychiatric services and addiction treatment services","volume":"6","author":"Lovrecic","year":"2004","journal-title":"Heroin Addict. Relat. Clin. Probl."},{"key":"ref_48","unstructured":"Galanter, M. (1993). Network Terapy for Alcohol and Drug Abuse: A New Approach in Practice, Basic Books."},{"key":"ref_49","first-page":"557","article-title":"Expectations and satisfaction of social-psychiatric services regarding their collaboraton with the psychiatric hospital","volume":"68","author":"Spiessl","year":"2000","journal-title":"Neurol. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/002076406300900105","article-title":"A survey of unmet needs for psychiatric, psychological and social services in an urban community","volume":"9","author":"Shapiro","year":"1963","journal-title":"Int. J. Soc. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00127-003-0604-9","article-title":"Predictors of improvement in quality of life of severely mentally ill substance abusers during 18 months of co-operation between psychiatric and social services","volume":"38","author":"Schaar","year":"2003","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_52","first-page":"103","article-title":"Need for social psychiatric services\u2014A management model in scientific evaluation","volume":"27","author":"Rossler","year":"1988","journal-title":"Die Rehabil."},{"key":"ref_53","first-page":"2205","article-title":"Drug addicts with severe mental disorders can be helped by programs using moderate means. Good results when psychiatric, social and drug abuse services cooperate","volume":"97","author":"Palmstierna","year":"2000","journal-title":"Lakartidningen"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3109\/00048679509064947","article-title":"The relationship between social factors and frequent use of psychiatric services","volume":"29","author":"Kent","year":"1995","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_55","first-page":"13","article-title":"Psychiatric social services: Caring for the whole person","volume":"4","author":"Anthony","year":"1977","journal-title":"Concern Care Aging"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1300\/J465v26n03_06","article-title":"Community-Based Substance Abuse Training","volume":"26","author":"Bonder","year":"2006","journal-title":"Subst. Abus."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Michaud, P.-A., B\u00e9langer, R., Mazur, A., Hadjipanayis, A., and Ambresin, A.-E. (2020). How can primary care practitioners address substance use by adolescents? A position paper of the EUROPEAN academy of PAEDIATRICS. Eur. J. Pediatr.","DOI":"10.1007\/s00384-020-03572-4"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1542\/peds.2004-2841","article-title":"Tobacco, Alcohol, and Other Drugs: The Role of the Pediatrician in Prevention, Identification, and Management of Substance Abuse","volume":"115","author":"Kulig","year":"2005","journal-title":"Pediatrics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/archpedi.156.6.607","article-title":"Validity of the CRAFFT substance abuse screening test among adolescent clinic patients","volume":"156","author":"Knight","year":"2002","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-227X-14-13","article-title":"Brief motivational intervention for adolescents treated in emergency departments for acute alcohol intoxication\u2014A randomized-controlled trial","volume":"14","author":"Diestelkamp","year":"2014","journal-title":"BMC Emerg. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/1742-6723.12488","article-title":"Adolescent presentations with alcohol intoxication to the emergency department at Joondalup Health Campus in 2013","volume":"27","author":"Lovegrove","year":"2015","journal-title":"Emerg. Med. Australas."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/7\/2122\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:47:53Z","timestamp":1760176073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/7\/2122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":61,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["jcm9072122"],"URL":"https:\/\/doi.org\/10.3390\/jcm9072122","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]}}}