{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:09:41Z","timestamp":1790456981873,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-02470"],"award-info":[{"award-number":["2018-02470"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"County Council of \u00d6sterg\u00f6tland","award":["LIO-624191"],"award-info":[{"award-number":["LIO-624191"]}]},{"name":"County Council of \u00d6sterg\u00f6tland","award":["LIO-926131"],"award-info":[{"award-number":["LIO-926131"]}]},{"name":"County Council of \u00d6sterg\u00f6tland","award":["LIO-700931 (research-ALF)"],"award-info":[{"award-number":["LIO-700931 (research-ALF)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Although chronic pain is common in patients with Ehlers\u2013Danlos syndrome (EDS) and hypermobility syndromes (HMS), little is known about the clinical characteristics of these groups. The main aim was to compare EDS\/HMS with common local and generalized pain conditions with respect to Patient Reported Outcome Measures (PROMs). Data from the Swedish Quality Register for Chronic Pain (SQRP) from 2007 to 2016 (n = 40,518) were used, including patients with EDS\/HMS (n = 795), fibromyalgia (n = 5791), spinal pain (n = 6693), and whiplash associated disorders (WAD) (n = 1229). No important differences in the PROMs were found between EDS and HMS. Women were represented in &gt; 90% of EDS\/HMS cases and fibromyalgia cases, and in about 64% of the other groups. The EDS\/HMS group was significantly younger than the others but had a longer pain duration. The pain intensity in EDS\/HMS was like those found in spinal pain and WAD; fibromyalgia had the highest pain intensity. Depressive and anxiety symptoms were very similar in the four groups. Vitality\u2014a proxy for fatigue\u2014was low both in EDS\/HMS and fibromyalgia. The physical health was lower in EDS\/HMS and fibromyalgia than in the two other groups. Patients with EDS\/HMS were younger, more often female, and suffered from pain for the longest time compared with patients who had localized\/regional pain conditions. Health-care clinicians must be aware of these issues related to EDS\/HMS both when assessing the clinical presentations and planning treatment and rehabilitation interventions.<\/jats:p>","DOI":"10.3390\/jcm9072143","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T10:41:09Z","timestamp":1594118469000},"page":"2143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ehlers\u2013Danlos Syndrome and Hypermobility Syndrome Compared with Other Common Chronic Pain Diagnoses\u2014A Study from the Swedish Quality Registry for Pain Rehabilitation"],"prefix":"10.3390","volume":"9","author":[{"given":"Peter","family":"Molander","sequence":"first","affiliation":[{"name":"Pain and Rehabilitation Centre and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, 581 83 Link\u00f6ping, Sweden"},{"name":"Department of Behavioural Sciences and Learning, Link\u00f6ping University, 581 83 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-9299","authenticated-orcid":false,"given":"Mehmed","family":"Novo","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Rehabilitation, Rehabilitation Medicine, Ume\u00e5 University, SE-905 87 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-7251","authenticated-orcid":false,"given":"Andrea","family":"H\u00e5llstam","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, SE-182 88 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8701-0206","authenticated-orcid":false,"given":"Monika","family":"L\u00f6fgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, SE-182 88 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt-Marie","family":"St\u00e5lnacke","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Rehabilitation, Rehabilitation Medicine, Ume\u00e5 University, SE-905 87 Ume\u00e5, Sweden"},{"name":"Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, SE-182 88 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4316-1264","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Gerdle","sequence":"additional","affiliation":[{"name":"Pain and Rehabilitation Centre and Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, 581 83 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ajmg.c.31552","article-title":"The 2017 international classification of the Ehlers\u2013Danlos syndromes","volume":"175","author":"Malfait","year":"2017","journal-title":"Am. 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