{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:17:45Z","timestamp":1790759865122,"version":"4.1.0"},"reference-count":99,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Through a recent upsurge of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, the clinical assessment of most of the coronavirus disease 19 (COVID-19) patients clearly presents a health condition with the loss of oro-naso-sensory (ONS) perception, responsible for the detection of flavor and savor. These changes include anosmia and dysgeusia. In some cases, these clinical manifestations appear even before the general flu-like symptoms, e.g., sore throat, thoracic oppression and fever. There is no direct report available on the loss of these chemical senses in obese COVID-19 patients. Interestingly, obesity has been shown to be associated with low ONS cues. These alterations in obese subjects are due to obesity-induced altered expression of olfacto-taste receptors. Besides, obesity may further aggravate the SARS-CoV-2 infection, as this pathology is associated with a high degree of inflammation\/immunosuppression and reduced protection against viral infections. Hence, obesity represents a great risk factor for SARS-CoV-2 infection, as it may hide the viral-associated altered ONS symptoms, thus leading to a high mortality rate in these subjects.<\/jats:p>","DOI":"10.3390\/jcm9072158","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:45:31Z","timestamp":1594374331000},"page":"2158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Obesity and COVID-19: Oro-Naso-Sensory Perception"],"prefix":"10.3390","volume":"9","author":[{"given":"Amira Sayed","family":"Khan","sequence":"first","affiliation":[{"name":"Centre de Recherche Inserm, U1231 INSERM\/UB\/AgroSup, Team\u2014Physiologie de la Nutrition &amp; Toxicologie, Universit\u00e9 de Bourgogne Franche-Comt\u00e9 (UBFC), Facult\u00e9 des Sciences de la Vie, 6 Boulevard Gabriel, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-5152","authenticated-orcid":false,"given":"Aziz","family":"Hichami","sequence":"additional","affiliation":[{"name":"Centre de Recherche Inserm, U1231 INSERM\/UB\/AgroSup, Team\u2014Physiologie de la Nutrition &amp; Toxicologie, Universit\u00e9 de Bourgogne Franche-Comt\u00e9 (UBFC), Facult\u00e9 des Sciences de la Vie, 6 Boulevard Gabriel, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-9332","authenticated-orcid":false,"given":"Naim Akhtar","family":"Khan","sequence":"additional","affiliation":[{"name":"Centre de Recherche Inserm, U1231 INSERM\/UB\/AgroSup, Team\u2014Physiologie de la Nutrition &amp; Toxicologie, Universit\u00e9 de Bourgogne Franche-Comt\u00e9 (UBFC), Facult\u00e9 des Sciences de la Vie, 6 Boulevard Gabriel, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijid.2020.01.009","article-title":"The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health\u2014The latest 2019 novel coronavirus outbreak in Wuhan, China","volume":"91","author":"Hui","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalized with COVID-19 in the New York City Area","volume":"323","author":"Richardson","year":"2020","journal-title":"Jama"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The Epidemiology of Obesity: A Big Picture","volume":"33","author":"Hruby","year":"2015","journal-title":"Pharmacoeconomics"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Van Kerkhove, M.D., Vandemaele, K.A., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C.A., Carlino, L.O., Owen, R., Paterson, B., and Pelletier, L. (2011). Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: A global pooled analysis. PLoS Med., 8.","DOI":"10.1371\/journal.pmed.1001053"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fphar.2020.00056","article-title":"Contrasting effects of adipokines on the cytokine production by primary human bronchial epithelial cells: Inhibitory effects of adiponectin","volume":"11","author":"Salvator","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1093\/cid\/civ060","article-title":"Adiposity and influenza-associated respiratory mortality: A cohort study","volume":"60","author":"Zhou","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"19309","DOI":"10.2807\/ese.14.33.19309-en","article-title":"Epidemic intelligence team at In VS Epidemiology of fatal cases associated with pandemic H1N1 influenza 2009","volume":"14","author":"Vaillant","year":"2009","journal-title":"Eurosurveillance"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5858\/134.2.235","article-title":"Pulmonary pathologic findings of fatal 2009 pandemic influenza A\/H1N1 viral infections","volume":"134","author":"Gill","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","article-title":"The pathology of influenza virus infections","volume":"3","author":"Taubenberger","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3389\/fimmu.2019.01071","article-title":"Impact of obesity on influenza a virus pathogenesis, immune response, and evolution","volume":"10","author":"Honce","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S1473-3099(06)70523-0","article-title":"Obesity and infection","volume":"6","author":"Falagas","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., Labreuche, J., Mathieu, D., Pattou, F., and Jourdain, M. (2020). High Prevalence of Obesity in Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity.","DOI":"10.1002\/oby.22831"},{"key":"ref_14","first-page":"343","article-title":"Inflammation & Immunity: Implications in obesity and type-2 diabetes","volume":"13","author":"Khan","year":"2006","journal-title":"Oilseeds Fats Crop. Lipids"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1473-3099(10)70103-1","article-title":"Obesity and the outcome of infection","volume":"10","author":"Huttunen","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1473-3099(10)70304-2","article-title":"Obesity-related immunodeficiency in patients with pandemic influenza H1N1","volume":"11","author":"Nave","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ijo.2011.208","article-title":"Obesity is associated with impaired immune response to influenza vaccination in humans","volume":"36","author":"Sheridan","year":"2011","journal-title":"Int. J. Obes."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tan, M., Liu, Y., Zhou, R., Deng, X., Li, F., Liang, K., and Shi, Y. (2020). Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China. Immunology.","DOI":"10.1111\/imm.13223"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1099\/0022-1317-80-4-823","article-title":"Virus interactions with dendritic cells","volume":"80","author":"Klagge","year":"1999","journal-title":"J. Gen. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/ijo.2013.16","article-title":"Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection","volume":"37","author":"Corrigan","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27158","DOI":"10.1074\/jbc.M115.682708","article-title":"Interleukin 10 (IL-10)-mediated Immunosuppression march-i induction regulates antigen presentation by macrophages but not dendritic cells","volume":"290","author":"Mittal","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.4049\/jimmunol.174.11.6820","article-title":"Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming","volume":"174","author":"Mattioli","year":"2005","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI117899","article-title":"The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase","volume":"95","author":"Kern","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: The link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"Trends Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1039\/c0fo00113a","article-title":"Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: A tool to study inflammation modulating effects of food-derived compounds","volume":"1","author":"Chanput","year":"2010","journal-title":"Food Funct."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1210\/jc.2018-01833","article-title":"Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis","volume":"104","author":"Biobaku","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.semcancer.2012.02.008","article-title":"New Insights into Chronic Inflammation-Induced Immunosuppression","volume":"22","author":"Kanterman","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1017\/S0029665112000158","article-title":"The impact of obesity on the immune response to infection","volume":"71","author":"Milner","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00592-020-01522-8","article-title":"Influenza and obesity: Its odd relationship and the lessons for COVID-19 pandemic","volume":"57","author":"Luzi","year":"2020","journal-title":"Acta Diabetol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bello-Chavolla, O.Y., Bahena-L\u00f3pez, J.P., Antonio-Villa, N.E., Vargas-V\u00e1zquez, A., Gonz\u00e1lez-D\u00edaz, A., M\u00e1rquez-Salinas, A., Ferm\u00edn-Mart\u00ednez, C.A., Naveja, J.J., and Aguilar-Salinas, C.A. (2020). Predicting mortality due to SARS-CoV-2: A mechanistic score relating obesity and diabetes to COVID-19 outcomes in Mexico. J. Clin. Endocrinol. Metab.","DOI":"10.1101\/2020.04.20.20072223"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Berbudi, A., Rahmadika, N., Cahyadi, A.I., and Ruslami, R. (2019). Type 2 diabetes and its impact on the immune system. Curr. Diabetes Rev.","DOI":"10.2174\/1573399815666191024085838"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41574-020-0353-9","article-title":"Endocrine and metabolic link to coronavirus infection","volume":"16","author":"Bornstein","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Cariou, B., Hadjadj, S., Wargny, M., Pichelin, M., Al-Salameh, A., Allix, I., Amadou, C., Arnault, G., Baudoux, F., and Bauduceau, B. (2020). Phenotypic characteristics and prognosis of in-patients with COVID-19 and diabetes: The CORONADO study. Diabetologia.","DOI":"10.1007\/s00125-020-05180-x"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Scheen, A.J., Marre, M., and Thivolet, C. (2020). Prognostic factors in patients with diabetes hospitalized for COVID-19: Findings from the CORONADO study and other recent reports. Diabetes Metab., in press, corrected proof.","DOI":"10.1016\/j.diabet.2020.05.008"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3892\/mmr.2020.11127","article-title":"Obesity\u2014A risk factor for increased COVID-19 prevalence, severity and lethality (Review)","volume":"2","author":"Petrakis","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1515\/dx-2020-0046","article-title":"Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): Early report from the United States","volume":"7","author":"Aggarwal","year":"2020","journal-title":"Diagnosis"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Xydakis, M.S., Dehgani-Mobaraki, P., Holbrook, E.H., Geisthoff, U.W., Bauer, C., Hautefort, C., Herman, P., Manley, G.T., Lyon, D.M., and Hopkins, C. (2020). Smell and taste dysfunction in patients with COVID-19. Lancet Infect. Dis.","DOI":"10.1016\/S1473-3099(20)30293-0"},{"key":"ref_38","first-page":"e35","article-title":"Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis","volume":"24","author":"Emami","year":"2020","journal-title":"Arch. Acad. Emerg. Med."},{"key":"ref_39","first-page":"1","article-title":"Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study","volume":"6","author":"Lechien","year":"2020","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tong, J.Y., Wong, A., Zhu, D., Fastenberg, J.H., and Tham, T. (2020). The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: A systematic review and meta-analysis. Otolaryngol.-Head Neck Surg.","DOI":"10.1177\/0194599820926473"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/oby.22809","article-title":"A New Symptom of COVID-19: Loss of Taste and Smell","volume":"28","author":"Gautierr","year":"2020","journal-title":"Obesity"},{"key":"ref_42","unstructured":"Stone, J. (Forbes, 2020). There\u2019s an Unexpected Loss of Smell and Taste in Coronavirus Patients, Forbes."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Coelho, D.H., Kons, Z.A., Costanzo, R.M., and Reiter, E.R. (2020). Subjective Changes in Smell and Taste during the COVID-19 Pandemic: A National Survey-Preliminary Results. Otolaryngol.-Head Neck Surg., 19.","DOI":"10.1177\/0194599820929957"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Paderno, A., Schreiber, A., Grammatica, A., Raffetti, E., Tomasoni, M., Gualtieri, T., Taboni, S., Zorzi, S., Lombardi, D., and Deganello, A. Smell and taste alterations in Covid-19: A cross-sectional analysis of different cohorts. Int. Forum Allergy Rhinol., 2020.","DOI":"10.1002\/alr.22610"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mao, L., Wang, M., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., Miao, X., and Hu, Y. (2020). Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: A retrospective case series study. SSRN.","DOI":"10.2139\/ssrn.3544840"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, Y., Bai, W., and Hashikawa, T. (2020). The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J. Med. Virol.","DOI":"10.1002\/jmv.25728"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/infdis\/jiv499","article-title":"Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4","volume":"213","author":"Li","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1021\/acschemneuro.0c00210","article-title":"Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age","volume":"11","author":"Bilinska","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1749-6632.2009.04364.x","article-title":"Analysis of the olfactory mucosa in chronic rhinosinusitis","volume":"1170","author":"Yee","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Tian, J., Pinto, J.M., Cui, X., Zhang, H., Li, L., Liu, Y., Wu, C., and Wei, Y. (2016). Sendai virus induces persistent olfactory dysfunction in a murine model of PVOD via effects on apoptosis, cell proliferation, and response to odorants. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0159033"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/194589240501900302","article-title":"Development of transgenic mouse models for the study of human olfactory dysfunction","volume":"19","author":"Lane","year":"2005","journal-title":"Am. J. Rhinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/jnr.10432","article-title":"Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: Involvement of macrophage inflammatory proterin-alpha and monocyte chemoattractant protein-1","volume":"70","author":"Getchell","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41368-020-0074-x","article-title":"High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa","volume":"12","author":"Xu","year":"2020","journal-title":"Int. J. Oral. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1749-6632.2009.04480.x","article-title":"Inflammation and taste disorders: Mechanisms in taste buds","volume":"1170","author":"Hong","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/sj.ejcn.1601858","article-title":"Detection and recognition thresholds to the 4 basic tastes in Mexican patients with primary Sj\u00f6gren\u2019s syndrome","volume":"58","author":"Gomez","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0196-0709(83)80042-8","article-title":"Head and neck manifestations of autoimmune disease","volume":"4","author":"Campbell","year":"1983","journal-title":"Am. J. Otolaryngol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0361-9230(97)00107-X","article-title":"Reduced preference for sucrose in autoimmune mice: A possible role of interleukin-6","volume":"44","author":"Szechtman","year":"1997","journal-title":"Brain Res. Bull."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1523\/JNEUROSCI.3102-07.2007","article-title":"Inflammation activates the interferon signaling pathways in taste bud cells","volume":"27","author":"Wang","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chigr, F., Merzouki, M., and Najimi, M. (2020). Autonomic Brain Centers and Pathophysiology of COVID-19. ACS Chem. Neurosci.","DOI":"10.1021\/acschemneuro.0c00265"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Chigr, F., Merzouki, M., and Najimi, M. (2020). Comment on \u201cThe neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients\u201d. J. Med. Virol.","DOI":"10.1002\/jmv.25960"},{"key":"ref_62","first-page":"3440","article-title":"Defining the burden of olfactory dysfunction in COVID-19 patients","volume":"24","author":"Ralli","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11481-020-09924-9","article-title":"SARS-CoV-2 Infection Leads to Neurological Dysfunction","volume":"15","author":"Acharya","year":"2020","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1128\/JVI.00737-08","article-title":"Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2","volume":"82","author":"Netland","year":"2008","journal-title":"J. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Eliezer, M., Hautefort, C., Hamel, A.L., Verillaud, B., Herman, P., Houdart, E., and Eloit, C. (2020). Sudden and complete olfactory loss function as a possible symptom of COVID-19. JAMA Otolaryngol.-Head Neck Surg.","DOI":"10.1001\/jamaoto.2020.0832"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/path.1570","article-title":"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus: A first step in understanding SARS pathogenesis","volume":"203","author":"Hamming","year":"2004","journal-title":"J. Pathol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1098\/rstb.2006.1853","article-title":"Psychophysics of sweet and fat perception in obesity: Problems, solutions and new perspectives","volume":"361","author":"Bartoshuk","year":"2006","journal-title":"Philos Trans. R Soc. Lond B Biol. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ejcn.2014.139","article-title":"Associations between weight status and liking scores for sweet, salt and fat according to the gender in adults (The Nutrinet-Sante study)","volume":"69","author":"Deglaire","year":"2015","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1467-789X.2012.01031.x","article-title":"Obesity and addiction: Neurobiological overlaps","volume":"14","author":"Volkow","year":"2013","journal-title":"Obes. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Kochhar, K.P., and Khan, N.A. (2019). Fat Addiction: Psychological and Physiological Trajectory. Nutrients, 15.","DOI":"10.3390\/nu11112785"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4239\/wjd.v5.i5.717","article-title":"Taste sensitivity, nutritional status and metabolic syndrome: Implication in weight loss dietary interventions","volume":"5","author":"Bertoli","year":"2014","journal-title":"World J. Diabetes"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Maliphol, A.B., Garth, D.J., and Medler, K.F. (2013). Diet-induced obesity reduces the responsiveness of the peripheral taste receptor cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079403"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.appet.2011.05.107","article-title":"Taste perception and implicit attitude toward sweet related to body mass index and soft drink supplementation","volume":"57","author":"Sartor","year":"2011","journal-title":"Appetite"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physrev.00002.2015","article-title":"Taste of Fat: A Sixth Taste Modality?","volume":"96","author":"Besnard","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"101032","DOI":"10.1016\/j.plipres.2020.101032","article-title":"Preference for dietary fat: From detection to disease","volume":"78","author":"Khan","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1053\/j.gastro.2014.01.006","article-title":"CD36- and GPR120-Mediated Ca2+ Signaling in Human Taste Bud Cells Mediates Differential Responses to Fatty Acids and Is Altered in Obese Mice","volume":"146","author":"Ozdener","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3945\/ajcn.2010.29836","article-title":"Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations","volume":"92","author":"Eny","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_78","first-page":"300","article-title":"Genetic variation in CD36 is associated with decreased fat and sugar intake in obese childrenand adolescents","volume":"9","author":"Pioltine","year":"2016","journal-title":"J. Nutrigenet. Nutrigenom."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/MCO.0000000000000492","article-title":"Taste perception and its effects on oral nutritional supplements in younger life phases","volume":"21","author":"Khan","year":"2018","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/nutrit\/nuu009","article-title":"Taste perception, associated hormonal modulation, and nutrient intake","volume":"73","author":"Loper","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kindleysides, S., Beck, K.L., Walsh, D.C.I., Henderson, L., Jayasinghe, S.N., Golding, M., and Breier, B.H. (2017). Fat Sensation: Fatty Acid Taste and Olfaction Sensitivity and the Link with Disinhibited Eating Behaviour. Nutrients, 9.","DOI":"10.3390\/nu9080879"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbr.2017.05.015","article-title":"Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people","volume":"329","author":"Tomassini","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physbeh.2015.01.024","article-title":"Olfactory and gustatory functions and its relation to body weight","volume":"142","author":"Skrandies","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"675635","DOI":"10.1155\/2015\/675635","article-title":"Higher body mass index is associated with subjective olfactory dysfunction","volume":"2015","author":"Patel","year":"2015","journal-title":"Behav. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Pastor, A., Fern\u00e1ndez-Aranda, F., Fit\u00f3, M., Jim\u00e9nez-Murcia, S., Botella, C., Fern\u00e1ndez-Real, J.M., Fr\u00fchbeck, G., Tinahones, F.J., Fagundo, A.B., and Rodriguez, J. (2016). A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148734"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/hmg\/ddq518","article-title":"Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis","volume":"20","author":"Jarick","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s12263-015-0465-3","article-title":"Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity","volume":"10","author":"Mariman","year":"2015","journal-title":"Genes Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12263-019-0635-9","article-title":"Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes","volume":"14","author":"Milagro","year":"2019","journal-title":"Genes Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrn2883","article-title":"Central mechanisms of odour object perception","volume":"11","author":"Gottfried","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1523\/JNEUROSCI.3074-13.2014","article-title":"Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds","volume":"34","author":"Feng","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Kaufman, A., Choo, E., Koh, A., and Dando, R. (2018). Inflammation arising from obesity reduces taste bud abundance and inhibits renewal. PLoS Biol., 16.","DOI":"10.1371\/journal.pbio.2001959"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Cohn, Z.J., Kim, A., Huang, L., Brand, J., and Wang, H. (2010). Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells. BMC Neurosci., 11.","DOI":"10.1186\/1471-2202-11-72"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"6970","DOI":"10.1523\/JNEUROSCI.3366-13.2014","article-title":"Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimi-nation, and disrupts odor-reversal learning","volume":"34","author":"Thiebaud","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/exnr.2000.7465","article-title":"Tumor necrosis factor-alpha-induced apoptosis in olfactory epithelium in vitro: Possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32)","volume":"165","author":"Suzuki","year":"2000","journal-title":"Exp. Neurol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1001\/jamaoto.2013.3392","article-title":"Interleukin 6 in Hyposmia","volume":"139","author":"Henkin","year":"2013","journal-title":"JAMA Otolaryngol.-Head Neck Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1152\/jn.00050.2004","article-title":"Experience-dependent neural integration of taste and smell in the human brain","volume":"92","author":"Small","year":"2004","journal-title":"J. Neurophysiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"612","DOI":"10.5483\/BMBRep.2012.45.11.232","article-title":"Olfactory receptors in non-chemosensory tissues","volume":"45","author":"Kang","year":"2012","journal-title":"BMB Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/chemse\/bjs059","article-title":"Olfaction Under Metabolic Influences","volume":"37","author":"Lacroix","year":"2012","journal-title":"Chemical. Senses"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zuo, T., Zhang, F., Lui, G.C., Yeoh, Y.K., Li, A.Y., Zhan, H., Wan, Y., Chung, A., Cheung, C.P., and Chen, N. (2020). Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. 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