{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:12:40Z","timestamp":1790035960613,"version":"4.0.1"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The presence of a cardiovascular implantable electronic device (CIED) can be burdened by complications such as late infections that are associated with significant morbidity and mortality and require immediate and effective treatment. The aim of this study was to evaluate the role of 18F-fluorodeoxyglucose positron-emission tomography\/computed tomography (18F-FDG PET\/CT) in patients with suspected CIED infection. Fifteen patients who performed a 18F-FDG PET\/CT for suspicion of CIED infection were retrospectively analyzed; 15 patients, with CIED, that underwent 18F-FDG PET\/CT for oncological reasons, were also evaluated. Visual qualitative analysis and semi-quantitative analysis were performed. All patients underwent standard clinical management regardless 18F-FDG PET\/CT results. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) resulted as 90.91%, 75%, 86.67%, 90.91% and 75% respectively. Maximum standardized uptake values (SUVmax) and semi-quantitative ratio (SQR) were collected and showed differences statistically significant between CIED infected patients and those who were not. Exploratory cut-off values were derived from receiver operating characteristic (ROC) curves for SUVmax (2.56) and SQR (4.15). This study suggests the clinical usefulness of 18F-FDG PET\/CT in patients with CIED infection due to its high sensitivity, repeatability and non-invasiveness. It can help the clinicians in decision making, especially in patients with doubtful clinical presentation. Future large-scale and multicentric studies should be conducted to establish precise protocols about 18F-FDG PET\/CT performance.<\/jats:p>","DOI":"10.3390\/jcm9072246","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T03:23:16Z","timestamp":1595388196000},"page":"2246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Usefulness of 18F-FDG PET\/CT in Patients with Cardiac Implantable Electronic Device Suspected of Late Infection"],"prefix":"10.3390","volume":"9","author":[{"given":"Giuseppe","family":"Rubini","sequence":"first","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-8551","authenticated-orcid":false,"given":"Cristina","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Carretta","sequence":"additional","affiliation":[{"name":"CardioThoracic Department \u2013 Policlinic of Bari, Piazza Giulio Cesare, 11, 70124, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-8124","authenticated-orcid":false,"given":"Luigi","family":"Santacroce","sequence":"additional","affiliation":[{"name":"Ionian Department, Microbiology and Virology Lab \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Ruta","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5567-6171","authenticated-orcid":false,"given":"Francesca","family":"Iuele","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lavelli","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Merenda","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"CardioThoracic Department \u2013 Policlinic of Bari, Piazza Giulio Cesare, 11, 70124, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sardaro","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit, Interdisciplinary Department of Medicine \u2013 University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare, 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artor","family":"Niccoli Asabella","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, A. O. Policlinic \u201cA. Perrino\u201d, Strada Statale 7 per Mesagne, 72100 Brindisi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"ref_1","first-page":"597","article-title":"Infectious complications in patients with cardiac implantable electronic devices: Risk factors, prevention, and prognosis","volume":"127","author":"Polewczyk","year":"2017","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCEP.117.006101","article-title":"Cardiac Implantable Electronic Device Infections and Lead Extraction: Are Patients with Renal Insufficiency Special?","volume":"11","author":"Chrispin","year":"2018","journal-title":"Circ. 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