{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:05:36Z","timestamp":1790352336334,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Pediatrics at East Carolina University and the Brody School of Medicine","award":["Institutional funding"],"award-info":[{"award-number":["Institutional funding"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>There is no evidence-based definition for diagnosing crescentic glomerulonephritis. The prognostic implications of crescentic lesions on kidney biopsy have not been quantified. Our objective was to determine risk factors for end-stage kidney disease (ESKD) in patients with glomerulonephritis and crescents on kidney biopsy. A query of the Pediatric Nephrology Research Consortium\u2019s Pediatric Glomerulonephritis with Crescents registry identified 305 patients from 15 centers. A retrospective cohort study was performed with ESKD as the primary outcome. Median age at biopsy was 11 years (range 1\u201321). The percentage of crescents was 3\u2013100% (median 20%). Etiologies included IgA nephropathy (23%), lupus (21%), IgA vasculitis (19%) and ANCA-associated GN (13%), post-infectious GN (5%), and anti-glomerular basement membrane disease (3%). The prevalence of ESKD was 12% at one year and 16% at last follow-up (median = 3 years, range 1\u201311). Median time to ESKD was 100 days. Risk factors for ESKD included %crescents, presence of fibrous crescents, estimated GFR, and hypertension at biopsy. For each 1% increase in %crescents, there was a 3% decrease in log odds of 1-year renal survival (p = 0.003) and a 2% decrease in log odds of renal survival at last follow-up (p &lt; 0.001). These findings provide an evidence base for enrollment criteria for crescentic glomerulonephritis in future clinical trials.<\/jats:p>","DOI":"10.3390\/jcm9082385","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T09:24:49Z","timestamp":1595841889000},"page":"2385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Renal Survival in Children with Glomerulonephritis with Crescents: A Pediatric Nephrology Research Consortium Cohort Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Joseph G.","family":"Maliakkal","sequence":"first","affiliation":[{"name":"Pediatric Nephrology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX 77030, USA"},{"name":"Pediatric Nephrology, Saint Louis University, St. Louis, MO 63103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. John","family":"Hicks","sequence":"additional","affiliation":[{"name":"Pathology, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mini","family":"Michael","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Selewski","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Twombley","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-3970","authenticated-orcid":false,"given":"Michelle N.","family":"Rheault","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Seamon","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, The University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6800-7650","authenticated-orcid":false,"given":"Jason M.","family":"Misurac","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Tran","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-714X","authenticated-orcid":false,"given":"Loretta","family":"Reyes","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, University of Washington, Seattle, WA 98115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M.","family":"Onder","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, University of West Virginia, Morgantown, WV 26506, USA"},{"name":"Pediatric Nephrology, University of Mississippi, Jackson, MS 38677, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru R.","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Joe DiMaggio Children\u2019s Hospital, Hollywood, FL 33021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Singh","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Pan","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun","family":"Omoloja","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Wright State University, Dayton, OH 45435, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Biostatistics, East Carolina University, Greenville, NC 27858, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Smoyer","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, The Ohio State University and Nationwide Children\u2019s Hospital, Columbus, OH 43205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, East Carolina University, Greenville, NC 27858, USA"},{"name":"Pediatric Nephrology, Hackensack Meridian Health, Neptune, NJ 07753, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-8277","authenticated-orcid":false,"given":"Scott E.","family":"Wenderfer","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Baylor College of Medicine and Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1046\/j.1523-1755.1999.07005.x","article-title":"Management of idiopathic crescentic and diffuse proliferative glomerulonephritis: Evidence\u2014Based recommendations","volume":"70","author":"Jindal","year":"1999","journal-title":"Kidney Int. 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