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The pathogenesis of sarcoidosis is not yet completely understood, although in recent years, considerable efforts were put to develop novel experimental research models of sarcoidosis. In particular, sarcoidosis patient cells were used within in vitro 3D models to study their characteristics compared to control patients. Likewise, a series of transgenic mouse models were developed to highlight the role of particular signaling pathways in granuloma formation and persistence. The purpose of this review is to put in perspective the contributions of the most recent models in the understanding of sarcoidosis.<\/jats:p>","DOI":"10.3390\/jcm9082445","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T04:15:31Z","timestamp":1596168931000},"page":"2445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Models Contribution to the Understanding of Sarcoidosis Pathogenesis: \u201cAre There Good Models of Sarcoidosis?\u201d"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-629X","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Besnard","sequence":"first","affiliation":[{"name":"UMR 1272, Hypoxie &amp; Poumon, Universit\u00e9 Sorbonne Paris Nord, 1 rue de Chablis, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-5569","authenticated-orcid":false,"given":"Florence","family":"Jeny","sequence":"additional","affiliation":[{"name":"UMR 1272, Hypoxie &amp; Poumon, Universit\u00e9 Sorbonne Paris Nord, 1 rue de Chablis, 93017 Bobigny, France"},{"name":"AP-HP, H\u00f4pital Avicenne, Service de Pneumologie, 93017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(13)60680-7","article-title":"Sarcoidosis","volume":"383","author":"Valeyre","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","article-title":"Diagnosis and Detection of Sarcoidosis. 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