{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:52:12Z","timestamp":1792288332084,"version":"4.4.0"},"reference-count":189,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Venous thromboembolism (VTE) is the third most common cause of vascular mortality worldwide and comprises deep-vein thrombosis (DVT) and pulmonary embolism (PE). In this review, we discuss how an understanding of VTE epidemiology and the results of thromboprophylaxis trials have shaped the current approach to VTE prevention. We will discuss modern thromboprophylaxis as it pertains to genetic risk factors, exogenous hormonal therapies, pregnancy, surgery, medical hospitalization, cancer, and what is known thus far about VTE in COVID-19 infection.<\/jats:p>","DOI":"10.3390\/jcm9082467","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T07:45:57Z","timestamp":1596440757000},"page":"2467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Prevention of Venous Thromboembolism in 2020 and Beyond"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8158-3628","authenticated-orcid":false,"given":"Matthew","family":"Nicholson","sequence":"first","affiliation":[{"name":"Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinai","family":"Bhagirath","sequence":"additional","affiliation":[{"name":"Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.115.306841","article-title":"Global Burden of Thrombosis: Epidemiologic Aspects","volume":"118","author":"Wendelboe","year":"2016","journal-title":"Circ. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1001\/archinte.1991.00400050081016","article-title":"A Population-Based Perspective of the Hospital Incidence and Case-Fatality Rates of Deep Vein Thrombosis and Pulmonary Embolism: The Worcester DVT Study","volume":"151","author":"Anderson","year":"1991","journal-title":"Arch. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1055\/s-0037-1613887","article-title":"Incidence of venous thromboembolism: A community-based study in western France","volume":"83","author":"Oger","year":"2000","journal-title":"Thromb. Haemost."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Riva, N. (2020). Cerebral and Splanchnic Vein Thrombosis: Advances, Challenges, and Unanswered Questions. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030743"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0888-6296(88)90128-7","article-title":"Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin","volume":"2","author":"Collins","year":"1988","journal-title":"J. Cardiothorac. Anesth."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1378\/chest.13-2160","article-title":"Thrombosis prophylaxis and mortality risk among critically Ill adults","volume":"146","author":"Lilly","year":"2014","journal-title":"Chest"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4066\/AMJ.2015.2447","article-title":"Effect of medical thromboprophylaxis on mortality from pulmonary embolus and major bleeding","volume":"8","author":"Millar","year":"2015","journal-title":"Australas. Med. J."},{"key":"ref_8","first-page":"1","article-title":"Compliance with current VTE prophylaxis guidelines and risk factors linked to complications of VTE prophylaxis in medical inpatients: A prospective cohort study in a Spanish internal medicine department","volume":"8","year":"2018","journal-title":"BMJ Open"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1182\/bloodadvances.2018022954","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: Prophylaxis for hospitalized and nonhospitalized medical patients","volume":"2","author":"Cushman","year":"2018","journal-title":"Blood Adv."},{"key":"ref_10","unstructured":"Maynard, G. (2016). Preventing Hospital-Associated Venous Thromboembolism: A Guide for Effective Quality Improvement."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Siegal, D.M., Eikelboom, J.W., Lee, S.F., Rangarajan, S., Bosch, J., Zhu, J., and Yusuf, S. (2020). Variations in incidence of venous thromboembolism in low-, middle-, and high-income countries. Cardiovasc. Res., 1\u20139.","DOI":"10.1093\/cvr\/cvaa044"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjmed.2004.01.018","article-title":"Deep vein thrombosis and pulmonary embolism in two cohorts: The longitudinal investigation of thromboembolism etiology","volume":"117","author":"Cushman","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1001\/archinte.1997.00440360079008","article-title":"Deep vein thrombosis and pulmonary embolism in the general population. \u201cThe Study of Men Born in 1913\u201d","volume":"157","author":"Hansson","year":"1997","journal-title":"Arch. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2007.02450.x","article-title":"Incidence and mortality of venous thrombosis: A population-based study","volume":"5","author":"Christiansen","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archinte.158.6.585","article-title":"Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study","volume":"158","author":"Silverstein","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"832.e13","DOI":"10.1016\/j.amjmed.2013.02.024","article-title":"Incidence of and mortality from venous thromboembolism in a real-world population: The Q-VTE study cohort","volume":"126","author":"Tagalakis","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.thromres.2015.11.033","article-title":"The economic burden of incident venous thromboembolism in the United States: A review of estimated attributable healthcare costs","volume":"137","author":"Grosse","year":"2016","journal-title":"Thromb. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1160\/TH17-02-0134","article-title":"Incidence of Venous Thromboembolism in Asian Populations: A Systematic Review","volume":"117","author":"Lee","year":"2017","journal-title":"Thromb. Haemost."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1161\/CIRCULATIONAHA.109.921460","article-title":"Risk factors for venous thromboembolism: Results from the copenhagen city heart study","volume":"121","author":"Holst","year":"2010","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1160\/TH04-08-0506","article-title":"Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996","volume":"93","author":"White","year":"2005","journal-title":"Thromb. Haemost."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.afjem.2017.08.006","article-title":"A one year audit of patients with venous thromboembolism presenting to a tertiary hospital in Johannesburg, South Africa","volume":"8","author":"Goldstein","year":"2018","journal-title":"Afr. J. Emerg. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1468-1293.2010.00869.x","article-title":"HIV and risk of venous thromboembolism: A Danish nationwide population-based cohort study","volume":"12","author":"Rasmussen","year":"2011","journal-title":"HIV Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/acem.12471","article-title":"Systematic review and meta-analysis of pregnant patients investigated for suspected pulmonary embolism in the emergency department","volume":"21","author":"Kline","year":"2014","journal-title":"Acad. Emerg. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1001\/archinte.162.14.1631","article-title":"Use of a clinical decision rule in combination with D-dimer concentration in diagnostic workup of patients with suspected pulmonary embolism: A prospective management study","volume":"162","author":"Kruip","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa1813865","article-title":"Pregnancy-adapted YEARS algorithm for diagnosis of suspected pulmonary embolism","volume":"380","author":"Tromeur","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e351S","DOI":"10.1378\/chest.11-2299","article-title":"Diagnosis of DVT: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Bates","year":"2012","journal-title":"Chest"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1111\/jth.12918","article-title":"Fibrinogen, red blood cells, and factor XIII in venous thrombosis","volume":"13","author":"Walton","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1111\/j.1538-7836.2009.03629.x","article-title":"Comparison of the clinical history of symptomatic isolated distal deep-vein thrombosis vs. proximal deep vein thrombosis in 11086 patients","volume":"7","author":"Galanaud","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(69)90002-6","article-title":"Natural History Of Postoperative Deep-Vein Thrombosis","volume":"294","author":"Kakkar","year":"1969","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/01.CIR.0000078464.82671.78","article-title":"Natural history of venous thromboembolism","volume":"107","author":"Kearon","year":"2003","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/j.1538-7836.2007.02571.x","article-title":"Association between asymptomatic deep vein thrombosis detected by venography and symptomatic venous thromboembolism in patients undergoing elective hip or knee surgery","volume":"5","author":"Quinlan","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11239-014-1153-7","article-title":"A systematic review of contemporary trials of anticoagulants in orthopaedic thromboprophylaxis: Suggestions for a radical reappraisal","volume":"40","author":"Chan","year":"2015","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1055\/s-0039-1683374","article-title":"Recurrence Risk after First Symptomatic Distal versus Proximal Deep Vein Thrombosis According to Baseline Risk Factors","volume":"3","author":"Valerio","year":"2019","journal-title":"TH Open"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e419S","DOI":"10.1378\/chest.11-2301","article-title":"Antithrombotic therapy for VTE disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Kearon","year":"2012","journal-title":"Chest"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.thromres.2010.03.016","article-title":"Prevalence and Clinical History of Incidental, Asymptomatic Pulmonary Embolism: A Meta-Analysis","volume":"125","author":"Dentali","year":"2010","journal-title":"Thromb. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chest.2015.11.026","article-title":"Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report","volume":"149","author":"Kearon","year":"2016","journal-title":"Chest"},{"key":"ref_37","first-page":"1","article-title":"Emergency department visits by patients with venous thromboembolism, 1998\u20132009","volume":"1","author":"Yusuf","year":"2012","journal-title":"J. Hosp. Adm."},{"key":"ref_38","first-page":"CD010222","article-title":"Anticoagulant treatment for subsegmental pulmonary embolism","volume":"2","author":"Yoo","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_39","unstructured":"Carrier, M. (2020, May 24). A Study to Evaluate the Safety of Withholding Anticoagulation in Patients With Subsegmental PE Who Have a Negative Serial Bilateral Lower Extremity Ultrasound (SSPE). U.S National Library of Medicine Clinical Trials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01455818."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1200\/JCO.19.01461","article-title":"Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO clinical practice guideline update","volume":"38","author":"Key","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1160\/TH07-03-0212","article-title":"Venous Thromboembolism (VTE) in Europe","volume":"98","author":"Cohen","year":"2007","journal-title":"Thromb. Haemost."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11239-015-1311-6","article-title":"The epidemiology of venous thromboembolism","volume":"41","author":"Heit","year":"2016","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archinte.159.5.445","article-title":"Predictors of survival after deep vein thrombosis and pulmonary embolism: A population-based, cohort study","volume":"159","author":"Heit","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.thromres.2019.03.003","article-title":"Post-thrombotic syndrome: Short and long-term incidence and risk factors","volume":"177","author":"Tick","year":"2019","journal-title":"Thromb. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1538-7836.2005.01216.x","article-title":"Predictors of the post-thrombotic syndrome during long-term treatment of proximal deep vein thrombosis","volume":"3","author":"Kahn","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ende-Verhaar, Y.M., Cannegieter, S.C., Noordegraaf, A.V., Delcroix, M., Pruszczyk, P., Mairuhu, A.T.A., Huisman, M.V., and Klok, F.A. (2017). Incidence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: A contemporary view of the published literature. Eur. Respir. J., 49.","DOI":"10.1183\/13993003.01792-2016"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1056\/NEJMoa032274","article-title":"Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism","volume":"350","author":"Pengo","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_48","first-page":"1","article-title":"Quality of initial anticoagulant treatment and risk of CTEPH after acute pulmonary embolism","volume":"15","author":"Boon","year":"2020","journal-title":"PLoS ONE"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.thromres.2017.07.025","article-title":"Late consequences of venous thromboembolism: Measuring quality of life after deep vein thrombosis and pulmonary embolism","volume":"164","author":"Ghanima","year":"2018","journal-title":"Thromb. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.thromres.2017.06.017","article-title":"Late outcomes of pulmonary embolism: The post-PE syndrome","volume":"164","author":"Sista","year":"2018","journal-title":"Thromb. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jama.2010.43","article-title":"Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: A systematic review and meta-analysis","volume":"303","author":"Johnson","year":"2010","journal-title":"JAMA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1160\/TH13-07-0562","article-title":"Mandatory contrast-enhanced venography to detect deep-vein thrombosis (DVT) in studies of DVT prophylaxis: Upsides and downsides","volume":"111","author":"Hirsh","year":"2013","journal-title":"Thromb. Haemost."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s11239-019-01808-x","article-title":"Thromboembolism in children with cancer: A retrospective multicenter study in Korea","volume":"47","author":"Choi","year":"2019","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1182\/blood.V83.5.1251.1251","article-title":"Venous thromboembolic complications (VTE) in children: First analyses of the Canadian registry of VTE","volume":"83","author":"Andrew","year":"1994","journal-title":"Blood"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1365-2141.2008.07243.x","article-title":"Clinical features and outcome of pulmonary embolism in children","volume":"142","author":"Biss","year":"2008","journal-title":"Br. J. Haematol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.chest.2016.10.056","article-title":"Clinical Prognosis of Nonmassive Central and Noncentral Pulmonary Embolism: A Registry-Based Cohort Study","volume":"151","author":"Gouin","year":"2017","journal-title":"Chest"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4933-5-12","article-title":"Hemostasis and ageing","volume":"5","author":"Mari","year":"2008","journal-title":"Immun. Ageing"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-2141.2008.07339.x","article-title":"Does thrombophilia testing help in the clinical management of patients?","volume":"143","author":"Middeldorp","year":"2008","journal-title":"Br. J. Haematol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1160\/TH09-01-0013","article-title":"The genetics of venous thromboembolism: A meta-analysis involving ~120,000 cases and 180,000 controls","volume":"102","author":"Gohil","year":"2009","journal-title":"Thromb. Haemost."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1399-0004.2011.01746.x","article-title":"Management of inherited thrombophilia: Guide for genetics professionals","volume":"81","author":"Varga","year":"2012","journal-title":"Clin. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","article-title":"World distribution of factor V Leiden","volume":"346","author":"Rees","year":"1995","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/MBC.0000000000000562","article-title":"Global prevalence of prothrombin gene mutation G20210A and implications in women\u2019s health: A systematic review","volume":"27","author":"Dziadosz","year":"2016","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1046\/j.1365-2141.2001.02813.x","article-title":"A study of Protein S antigen levels in 3788 healthy volunteers: Influence of age, sex and hormone use, and estimate for prevalence of deficiency state","volume":"113","author":"Dykes","year":"2001","journal-title":"Br. J. Haematol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0038-1653730","article-title":"Prevalence of protein C deficiency in the healthy population","volume":"73","author":"Tait","year":"1995","journal-title":"Thromb. Haemost."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1055\/s-0038-1625983","article-title":"Risk of Venous Thrombosis in Antithrombin Deficiency: A Systematic Review and Bayesian Meta-analysis","volume":"44","author":"Croles","year":"2018","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1001\/archinte.160.22.3415","article-title":"An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: The sirius study","volume":"160","author":"Samama","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10654-013-9825-8","article-title":"Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: A meta-analysis involving over 11,000 cases and 21,000 controls","volume":"28","author":"Simone","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.crvasa.2013.01.007","article-title":"Homocysteine and venous thromboembolism-is there any link?","volume":"55","year":"2013","journal-title":"Cor Vasa"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/01.ATV.21.2.289","article-title":"Familial clustering of high factor VIII levels in patients with venous thromboembolism","volume":"21","author":"Schambeck","year":"2001","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archinte.166.7.729","article-title":"Risk of recurrent venous thromboembolism in patients with common thrombophilia: A systematic review","volume":"166","author":"Ho","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e419S","DOI":"10.1378\/chest.11-2301","article-title":"Antithrombotic Therapy for VTE Disease","volume":"141","author":"Kearon","year":"2012","journal-title":"Chest J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.thromres.2019.07.030","article-title":"High risk of thrombosis recurrence in patients with homozygous and compound heterozygous factor V R506Q (Factor V Leiden) and prothrombin G20210A","volume":"182","author":"Federici","year":"2019","journal-title":"Thromb. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1001\/jama.2009.853","article-title":"Predictive Value of Factor V Leiden and Prothrombin G20210A in Adults With Venous Thromboembolism and in Family Members of Those With a Mutation","volume":"301","author":"Segal","year":"2009","journal-title":"JAMA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/CIRCULATIONAHA.109.906347","article-title":"Risk of recurrent venous thrombosis in homozygous carriers and double heterozygous carriers of factor v leiden and prothrombin G20210A","volume":"121","author":"Lijfering","year":"2010","journal-title":"Circulation"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1161\/ATVBAHA.110.211482","article-title":"The risk of deep venous thrombosis associated with injectable depot-medroxyprogesterone acetate contraceptives or a levonorgestrel intrauterine device","volume":"30","author":"Helmerhorst","year":"2010","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"h2921","DOI":"10.1136\/bmj.b2921","article-title":"The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: Results of the MEGA case-control study","volume":"339","author":"Vlieg","year":"2001","journal-title":"Br. Med. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.thromres.2018.03.005","article-title":"Systematic review and meta-analysis of the association of combined oral contraceptives on the risk of venous thromboembolism: The role of the progestogen type and estrogen dose","volume":"165","author":"Oedingen","year":"2018","journal-title":"Thromb. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.e2990","article-title":"Venous thrombosis in users of non-oral hormonal contraception: Follow-up study, Denmark 2001\u201310","volume":"344","author":"Lidegaard","year":"2012","journal-title":"BMJ"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0010-7824(01)00307-9","article-title":"Oral contraceptives and venous thromboembolism: A five-year national case-control study","volume":"65","author":"Lidegaard","year":"2002","journal-title":"Contraception"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/S0140-6736(95)91928-7","article-title":"Risk of idiopathic cardiovascular death and rionfatal venous thromboembolism in women using oral contraceptives with differing progestagen components","volume":"346","author":"Jick","year":"1995","journal-title":"Lancet"},{"key":"ref_81","first-page":"1","article-title":"The Risk of Venous Thromboembolism with Different Generation of Oral Contraceptives; a Systematic Review and Meta-Analysis","volume":"2","author":"Baratloo","year":"2014","journal-title":"Emergency"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/bmj.39555.441944.BE","article-title":"Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: Systematic review and meta-analysis","volume":"336","author":"Canonico","year":"2008","journal-title":"BMJ"},{"key":"ref_83","first-page":"1","article-title":"Use of hormone replacement therapy and risk of venous thromboembolism: Nested case-control studies using the QResearch and CPRD databases","volume":"364","author":"Vinogradova","year":"2019","journal-title":"BMJ"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archinte.160.6.809","article-title":"Risk factors for deep vein thrombosis and pulmonary embolism: A population-based case-control study","volume":"160","author":"Heit","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Cannegieter, S.C., Doggen, C.J.M., Van Houwelingen, H.C., and Rosendaal, F.R. (2006). Travel-Related Venous Thrombosis: Results from a Large Population-Based Case Control Study (MEGA Study). PLoS Med., 3.","DOI":"10.1371\/journal.pmed.0030307"},{"key":"ref_86","first-page":"1","article-title":"Association of Testosterone Therapy with Risk of Venous Thromboembolism among Men with and without Hypogonadism","volume":"55413","author":"Walker","year":"2019","journal-title":"JAMA Intern. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1258\/jrsm.2008.070366","article-title":"A case-control study of seated immobility at work as a risk factor for venous thromboembolism","volume":"101","author":"West","year":"2008","journal-title":"J. R. Soc. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.3324\/haematol.2015.134882","article-title":"Le Risk of recurrent venous thromboembolism on progestin-only contraception: A cohort study","volume":"101","author":"Moigne","year":"2016","journal-title":"Haematologica"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.contraception.2016.04.014","article-title":"Progestin-only contraception and thromboembolism: A systematic review","volume":"94","author":"Tepper","year":"2016","journal-title":"Contraception"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1053\/j.semperi.2019.03.004","article-title":"Venous thromboembolism as a cause of severe maternal morbidity and mortality in the United States","volume":"43","author":"Abe","year":"2019","journal-title":"Semin. Perinatol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00006254-199904000-00023","article-title":"Deep vein thrombosis during pregnancy and the puerperium: A meta- analysis of the period of risk and the leg of presentation","volume":"54","author":"Ray","year":"1999","journal-title":"Obs. Gynecol. Surv."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood-2005-02-0626","article-title":"Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: A systematic review of safety and efficacy","volume":"106","author":"Greer","year":"2005","journal-title":"Blood"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1182\/bloodadvances.2018024802","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: Venous thromboembolism in the context of pregnancy","volume":"2","author":"Bates","year":"2018","journal-title":"Blood Adv."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijgo.2015.06.054","article-title":"A systematic review and meta-analysis of the epidemiology and burden of venous thromboembolism among pregnant women","volume":"132","author":"Kourlaba","year":"2016","journal-title":"Int. J. Gynecol. Obs."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e320","DOI":"10.1016\/S2352-3026(20)30007-7","article-title":"Risk of pregnancy-related venous thromboembolism and obstetrical complications in women with inherited type I antithrombin deficiency: A retrospective, single-centre, cohort study","volume":"7","author":"Abbattista","year":"2020","journal-title":"Lancet Haematol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1182\/blood-2016-03-703728","article-title":"Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium","volume":"128","author":"Gerhardt","year":"2016","journal-title":"Blood"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1016\/S2352-3026(20)30038-7","article-title":"Antithrombin deficiency in pregnancy\u2014The unresolved issues","volume":"7","author":"Kovac","year":"2020","journal-title":"Lancet Haematol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/9261351","article-title":"Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature","volume":"2017","author":"Refaei","year":"2017","journal-title":"Case Rep. Hematol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.thromres.2007.12.020","article-title":"Feasibility of an easy-to-use risk score in the prevention of venous thromboembolism and placental vascular complications in pregnant women: A prospective cohort of 2736 women","volume":"122","author":"Chauleur","year":"2008","journal-title":"Thromb. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/jth.13660","article-title":"Personalized thromboprophylaxis using a risk score for the management of pregnancies with high risk of thrombosis: A prospective clinical study","volume":"15","author":"Dargaud","year":"2017","journal-title":"J. Thromb. Haemost."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Sultan, A.A., West, J., Grainge, M.J., Riley, R.D., Tata, L.J., Stephansson, O., Fleming, K.M., Nelson-Piercy, C., and Ludvigsson, J.F. (2016). Development and validation of risk prediction model for venous thromboembolism in postpartum women: Multinational cohort study. BMJ, 355.","DOI":"10.1136\/bmj.i6253"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11739-014-1111-6","article-title":"The \u201cPregnancy Health-care Program\u201d for the prevention of venous thromboembolism in pregnancy","volume":"10","author":"Testa","year":"2015","journal-title":"Intern. Emerg. Med."},{"key":"ref_103","unstructured":"(2018). Reducing the risk of thrombosis and embolism during pregnancy and the puerperium. Green-top Guideline No. 37a. J. Matern. Neonatal Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/bmj.b4583","article-title":"Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: Prospective cohort study","volume":"339","author":"Sweetland","year":"2009","journal-title":"BMJ"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1007\/s00198-017-4213-y","article-title":"Excess risk of venous thromboembolism in hip fracture patients and the prognostic impact of comorbidity","volume":"28","author":"Pedersen","year":"2017","journal-title":"Osteoporos. Int."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1001\/jama.2011.2029","article-title":"IMECCHI Group, for the Symptomatic In-Hospital Deep Vein Thrombosis and Pulmonary Embolism Following Hip and Knee Arthroplasty Among Patients Receiving Recommended Prophylaxis","volume":"307","author":"Januel","year":"2012","journal-title":"JAMA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5792\/ksrr.2013.25.2.43","article-title":"Thromboprophylaxis for Deep Vein Thrombosis and Pulmonary Embolism after Total Joint Arthroplasty in a Low Incidence Population","volume":"25","author":"Kim","year":"2013","journal-title":"Knee Surg. Relat. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0145759","article-title":"Risk of post-discharge venous thromboembolism and associated mortality in general surgery: A population-based cohort study using linked hospital and primary care data in England","volume":"10","author":"Bouras","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1712746","article-title":"Aspirin or rivaroxaban for VTE prophylaxis after hip or knee arthroplasty","volume":"378","author":"Anderson","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1097\/AOG.0000000000002918","article-title":"Incidence of Venous Thromboembolism After Different Modes of Gynecologic Surgery","volume":"132","author":"Jorgensen","year":"2018","journal-title":"Obs. Gynecol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1182\/bloodadvances.2019000975","article-title":"American Society of Hematology 2019 guidelines for management of venous thromboembolism: Prevention of venous thromboembolism in surgical hospitalized patients","volume":"3","author":"Anderson","year":"2019","journal-title":"Blood Adv."},{"key":"ref_112","first-page":"304","article-title":"Clinical assessment of venous thromboembolic risk in surgical patients","volume":"17","author":"Caprini","year":"1991","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.disamonth.2005.02.003","article-title":"Thrombosis Risk Assessment as a Guide to Quality Patient Care","volume":"51","author":"Caprini","year":"2005","journal-title":"Disease-a-Month"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1001\/jamasurg.2015.1841","article-title":"Validation of the caprini venous thromboembolism risk assessment model in critically ill surgical patients","volume":"150","author":"Obi","year":"2015","journal-title":"Jama Surg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jamcollsurg.2010.08.018","article-title":"Validation of the Caprini Risk Assessment Model in Plastic and Reconstructive Surgery Patients","volume":"212","author":"Pannucci","year":"2011","journal-title":"J. Am. Coll. Surg."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/SLA.0000000000002126","article-title":"Individualized venous thromboembolism risk stratification using the 2005 caprini score to identify the benefits and harms of chemoprophylaxis in surgical patients: A meta-analysis","volume":"265","author":"Pannucci","year":"2017","journal-title":"Ann. Surg."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fas.2013.11.002","article-title":"The impact of risk assessment on the implementation of venous thromboembolism prophylaxis in foot and ankle surgery","volume":"20","author":"Saragas","year":"2014","journal-title":"Foot Ankle Surg."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jhm.1002","article-title":"Duration of venous thromboembolism risk across a continuum in medically ill hospitalized patients","volume":"7","author":"Amin","year":"2012","journal-title":"J. Hosp. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1378\/chest.10-1944","article-title":"Predictive and associative models to identify hospitalized medical patients at risk for VTE","volume":"140","author":"Spyropoulos","year":"2011","journal-title":"Chest"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1182\/blood.2019003603","article-title":"Prognostic factors for VTE and Bleeding in Hospitalized Medical Patients: A systematic review and and meta-analysis","volume":"135","author":"Darzi","year":"2020","journal-title":"Blood"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/jth.13942","article-title":"Addressing the burden of hospital-related venous thromboembolism: The role of extended anticoagulant prophylaxis","volume":"16","author":"Chan","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.CIR.0000138928.83266.24","article-title":"Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients","volume":"110","author":"Leizorovicz","year":"2004","journal-title":"Circulation"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJM199909093411103","article-title":"A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients","volume":"341","author":"Samama","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1111\/j.1538-7836.2010.04044.x","article-title":"A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: The Padua Prediction Score","volume":"8","author":"Barbar","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Vardi, M., Ghanem-Zoubi, N.O., Zidan, R., Yurin, V., and Bitterman, H. (2013). Venous thromboembolism and the utility of the Padua Prediction Score in patients with sepsis admitted to internal medicine departments. J. Thromb. Haemost., 467\u2013473.","DOI":"10.1111\/jth.12108"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1055\/s-0037-1603929","article-title":"The IMPROVEDD VTE Risk Score: Incorporation of D-Dimer into the IMPROVE Score to Improve Venous Thromboembolism Risk Stratification","volume":"1","author":"Gibson","year":"2017","journal-title":"TH Open"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1182\/blood.V118.21.4218.4218","article-title":"Venous Thromboembolism Validation Study of the IMPROVE Risk Assessment Models in the Medical Patient (VTE-VALOURR)","volume":"118","author":"Mahan","year":"2011","journal-title":"Blood"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.114.001152","article-title":"External validation of the risk assessment model of the international medical prevention registry on venous thromboembolism (IMPROVE) for medical patients in a tertiary health system","volume":"3","author":"Rosenberg","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1055\/s-0040-1705137","article-title":"Modified IMPROVE VTE Risk Score and Elevated D-Dimer Identify a High Venous Thromboembolism Risk in Acutely Ill Medical Population for Extended Thromboprophylaxis","volume":"4","author":"Spyropoulos","year":"2020","journal-title":"TH Open"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/archsurg.2012.2024","article-title":"Improved Prophylaxis and Decreased Rates of Preventable Harm With the Use of a Mandatory Computerized Clinical Decision Support Tool for Prophylaxis for Venous Thromboembolism in Trauma","volume":"147","author":"Haut","year":"2012","journal-title":"Arch. Surg."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jss.2018.01.013","article-title":"Fewer thromboembolic events after implementation of a venous thromboembolism risk stratification tool","volume":"225","author":"Turrentine","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e914","DOI":"10.1161\/CIR.0000000000000769","article-title":"Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement From the American Heart Association","volume":"141","author":"Henke","year":"2020","journal-title":"Circulation"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa1111096","article-title":"Rivaroxaban for thromboprophylaxis in acutely ill medical patients","volume":"368","author":"Cohen","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1056\/NEJMoa1601747","article-title":"Extended thromboprophylaxis with betrixaban in acutely ill medical patients","volume":"375","author":"Cohen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"MacDougall, K., and Spyropoulos, A.C. (2020). New Paradigms of Extended Thromboprophylaxis in Medically Ill Patients. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041002"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0008-6363(02)00857-X","article-title":"Infection and inflammation and the coagulation system","volume":"60","author":"Levi","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-015-1003-9","article-title":"Venous thromboembolism in the ICU: Main characteristics, diagnosis and thromboprophylaxis","volume":"19","author":"Minet","year":"2015","journal-title":"Crit. Care"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"key":"ref_139","first-page":"114","article-title":"Fibrinolysis Shutdown Correlation with Thromboembolic Events in Severe COVID-19 Infection","volume":"142","author":"Wright","year":"2020","journal-title":"J. Am. Coll. Surg."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Panigada, M., Bottino, N., Tagliabue, P., Grasselli, G., Novembrino, C., Chantarangkul, V., Pesenti, A., Peyvandi, F., and Tripodi, A. (2020). Hypercoagulability of COVID-19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis. J. Thromb. Haemost., 1738\u20131742.","DOI":"10.1111\/jth.14850"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Maatman, T.K., Jalali, F., Feizpour, C., Douglas, A., McGuire, S.P., Kinnaman, G., Hartwell, J.L., Maatman, B.T., Kreutz, R.P., and Kapoor, R. (2020). Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease 2019. Crit. Care Med., 1\u20138.","DOI":"10.1097\/CCM.0000000000004466"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Klok, F.A., Kruip, M.J.H.A., van der Meer, N.J.M., Arbous, M.S., Gommers, D., Kant, K.M., Kaptein, F.H.J., van Paassen, J., Stals, M.A.M., and Huisman, M.V. (2020). Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb. Res.","DOI":"10.1016\/j.thromres.2020.04.041"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S2213-2600(20)30243-5","article-title":"Pulmonary and cardiac pathology in African American patients with COVID-19: An autopsy series from New Orleans","volume":"8","author":"Fox","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.thromres.2020.04.024","article-title":"Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy","volume":"191","author":"Lodigiani","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.thromres.2020.05.018","article-title":"Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels","volume":"192","author":"Ji","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Cui, S., Chen, S., Li, X., Liu, S., and Wang, F. (2020). Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J. Thromb. Haemost.","DOI":"10.1111\/jth.14830"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Tavazzi, G., Civardi, L., Caneva, L., Mongodi, S., and Mojoli, F. (2020). Thrombotic events in SARS-CoV-2 patients: An urgent call for ultrasound screening. Intensive Care Med., 3\u20135.","DOI":"10.1007\/s00134-020-06040-3"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Poissy, J., Goutay, J., Caplan, M., Parmentier, E., Duburcq, T., Lassalle, F., Jeanpierre, E., Rauch, A., Labreuche, J., and Susen, S. (2020). Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence. Circulation, 1\u20136.","DOI":"10.1161\/CIRCULATIONAHA.120.047430"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Llitjos, J.-F., Leclerc, M., Chochois, C., Monsallier, J.-M., Ramakers, M., Auvray, M., and Merouani, K. (2020). High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J. Thromb. Haemost.","DOI":"10.1111\/jth.14869"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00134-020-06062-x","article-title":"High risk of thrombosis in patients with severe SARS-CoV-2 infection: A multicenter prospective cohort study","volume":"46","author":"Helms","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Middeldorp, S., Coppens, M., van Haaps, T.F., Foppen, M., Vlaar, A.P., M\u00fcller, M.C.A., Bouman, C.C.S., Beenen, L.F.M., Kootte, R.S., and Heijmans, J. (2020). Incidence of venous thromboembolism in hospitalized patients with COVID-19. J. Thromb. Haemost.","DOI":"10.20944\/preprints202004.0345.v1"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Zhang, L., Feng, X., Zhang, D., Jiang, C., Mei, H., Wang, J., Zhang, C., Li, H., Xia, X., and Kong, S. (2020). Deep Vein Thrombosis in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: Prevalence, Risk Factors, and Outcome. Circulation, 114\u2013128.","DOI":"10.1161\/CIRCULATIONAHA.120.046702"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.thromres.2020.04.028","article-title":"Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom","volume":"191","author":"Thomas","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jacc.2020.05.001","article-title":"Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19","volume":"76","author":"Paranjpe","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pmed.1001275","article-title":"Risk of venous thromboembolism in patients with cancer: A systematic review and meta-analysis","volume":"9","author":"Horsted","year":"2012","journal-title":"PLoS Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1200\/JCO.2012.42.4358","article-title":"Risk of venous thromboembolism in patients with cancer treated with cisplatin: A systematic review and meta-analysis","volume":"30","author":"Seng","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_157","first-page":"1","article-title":"Evaluation of risk factors and assessment models for predicting venous thromboembolism in lung cancer patients","volume":"35","author":"Lembicz","year":"2018","journal-title":"Med. Oncol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.thromres.2017.09.002","article-title":"Epidemiology of venous thromboembolism in hematological cancers: The Scandinavian Thrombosis and Cancer (STAC) cohort","volume":"158","author":"Gade","year":"2017","journal-title":"Thromb. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1053\/j.gastro.2019.12.009","article-title":"Incidence of Venous Thromboembolism in Patients With Newly diagnosed pancreatic Ca and factors associated with outcomes","volume":"158","author":"Frere","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1634\/theoncologist.2019-0510","article-title":"ONKOTEV Score as a Predictive Tool for Thromboembolic Events in Pancreatic Cancer\u2014A Retrospective Analysis","volume":"25","author":"Godinho","year":"2020","journal-title":"Oncologist"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1160\/TH05-10-0694","article-title":"Trousseau\u2019s syndrome\u2014What is the evidence? A population-based autopsy study","volume":"95","author":"Bergqvist","year":"2006","journal-title":"Thromb. Haemost."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1182\/blood-2007-10-116327","article-title":"Development and validation of a predictive model for chemotherapy-associated thrombosis","volume":"111","author":"Khorana","year":"2008","journal-title":"Blood"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1182\/blood-2010-02-270116","article-title":"Prediction of venous thromboembolism in cancer patients","volume":"116","author":"Ay","year":"2010","journal-title":"Blood"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1160\/TH15-09-0758","article-title":"Hypercoagulabilty, venous thromboembolism, and death in patients with cancer: A multi-state model","volume":"115","author":"Posch","year":"2016","journal-title":"Thromb. Haemost."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/jth.14139","article-title":"Risk stratification for the development of venous thromboembolism in hospitalized patients with cancer","volume":"16","author":"Parker","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ajh.24700","article-title":"Predicting risk of venous thromboembolism in hospitalized cancer patients: Utility of a risk assessment tool","volume":"92","author":"Patell","year":"2017","journal-title":"Am. J. Hematol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/1076029617699088","article-title":"Performance of Khorana Risk Score for Prediction of Venous Thromboembolism in Patients With Hepatocellular Carcinoma","volume":"24","author":"Wang","year":"2018","journal-title":"Clin. Appl. Thromb."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12959-019-0202-z","article-title":"Validation of the Khorana score in acute myeloid leukemia patients: A single-institution experience","volume":"17","author":"Mirza","year":"2019","journal-title":"Thromb. J."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1111\/jth.13378","article-title":"Predictors of active cancer thromboembolic outcomes: Validation of the Khorana score among patients with lung cancer","volume":"14","author":"Mansfield","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_170","first-page":"1","article-title":"Prediction of venous thromboembolism in newly diagnosed patients treated for lymphoid malignancies: Validation of the Khorana Risk Score","volume":"35","author":"Gil","year":"2018","journal-title":"Med. Oncol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1814468","article-title":"Apixaban to prevent venous thromboembolism in patients with cancer","volume":"380","author":"Carrier","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1056\/NEJMoa1814630","article-title":"Rivaroxaban for thromboprophylaxis in high-risk ambulatory patients with cancer","volume":"380","author":"Khorana","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1056\/NEJMoa1915103","article-title":"Apixaban for the treatment of venous thromboembolism associated with cancer","volume":"382","author":"Agnelli","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1056\/NEJMoa1711948","article-title":"Edoxaban for the treatment of cancer-associated venous thromboembolism","volume":"378","author":"Raskob","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1200\/JCO.2018.78.8034","article-title":"Comparison of an oral factor xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism: Results of a randomized trial (SELECT-D)","volume":"36","author":"Young","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Li, A., Carlson, J.J., Kuderer, N.M., Schaefer, J.K., Li, S., Garcia, D.A., Khorana, A.A., Carrier, M., and Lyman, G.H. (2020). Cost-effectiveness analysis of low-dose direct oral anticoagulant (DOAC) for the prevention of cancer-associated thrombosis in the United States. Cancer.","DOI":"10.1002\/cncr.32724"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e19000","DOI":"10.1097\/MD.0000000000019000","article-title":"Prevention of venous thromboembolism in patients with cancer with direct oral anticoagulants: A systematic review and meta-analysis","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1016\/S2352-3026(18)30063-2","article-title":"A clinical prediction model for cancer-associated venous thromboembolism: A development and validation study in two independent prospective cohorts","volume":"5","author":"Pabinger","year":"2018","journal-title":"Lancet Haematol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00520-018-4602-6","article-title":"Predictive factors for cancer-associated thrombosis in a large retrospective single-center study","volume":"27","author":"Haltout","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/jth.14662","article-title":"Apixaban and Dalteparin in Active Malignancy Associated Venous Thromboembolism: The ADAM VTE Trial","volume":"18","author":"McBane","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1056\/NEJMoa1405760","article-title":"Factor XI antisense oligonucleotide for prevention of venous thrombosis","volume":"372","author":"Bethune","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Bradley, M., Shi, A., Khatri, V., Schobel, S., Silvius, E., Kirk, A., Buchman, T., Oh, J., and Elster, E. (2020). Prediction of venous thromboembolism using clinical and serum biomarker data from a military cohort of trauma patients. BMJ Mil. Heal.","DOI":"10.1136\/bmjmilitary-2019-001393"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1158\/1078-0432.CCR-14-3358","article-title":"Soluble vascular endothelial growth factor (sVEGF) and the risk of venous thromboembolism in patients with cancer: Results from the Vienna cancer and Thrombosis Study (CATS)","volume":"22","author":"Posch","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/jth.13951","article-title":"Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients","volume":"16","author":"Mauracher","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.amjmed.2018.04.042","article-title":"Risk of Recurrent Venous Thromboembolism: A Danish Nationwide Cohort Study","volume":"131","author":"Albertsen","year":"2018","journal-title":"Am. J. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41512-019-0060-y","article-title":"Methodological standards for the development and evaluation of clinical prediction rules: A review of the literature","volume":"3","author":"Cowley","year":"2019","journal-title":"Diagn. Progn. Res."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Taha, H., Govindraj, E., Jaber, F., Shehadeh, G., Kelly, B., Krishnan, S., and Hamed, W.K. (2020). Improving venous thromboembolism prophylaxis through critical thinking and health informatics. BMJ Open Qual., 9.","DOI":"10.1136\/bmjoq-2019-000885"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s11739-018-1808-z","article-title":"Clinical impact of application of risk assessment models (Padua Prediction Score and Improve Bleeding Score) on venous thromboembolism, major hemorrhage and health expenditure associated with pharmacologic VTE prophylaxis: A \u201creal life\u201d prospective and re","volume":"13","author":"Depietri","year":"2018","journal-title":"Intern. Emerg. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/rth2.12292","article-title":"Machine learning to predict venous thrombosis in acutely ill medical patients","volume":"4","author":"Nafee","year":"2020","journal-title":"Res. Pr. Thromb. Haemost."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/8\/2467\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:53:32Z","timestamp":1760176412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/9\/8\/2467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":189,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["jcm9082467"],"URL":"https:\/\/doi.org\/10.3390\/jcm9082467","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}