{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:42:44Z","timestamp":1788486164998,"version":"build-2803163510"},"reference-count":75,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66\u20131.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.<\/jats:p>","DOI":"10.3390\/jcm9082478","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T07:45:57Z","timestamp":1596440757000},"page":"2478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality"],"prefix":"10.3390","volume":"9","author":[{"given":"Lisa","family":"Boucret","sequence":"first","affiliation":[{"name":"Reproductive Biology Unit, Angers University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Emmanuel","family":"Bouet","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Angers University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-9257","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Riou","sequence":"additional","affiliation":[{"name":"MINT, Angers University, INSERM 1066, CNRS 6021, IBS\u2013CHU, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Legendre","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Angers University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Delbos","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Angers University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hady El","family":"Hachem","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Saint Joseph Fertility Center, 1100 Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Descamps","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Angers University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-4608","authenticated-orcid":false,"given":"Pascal","family":"Reynier","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, Angers University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-7265","authenticated-orcid":false,"given":"Pascale","family":"May-Panloup","sequence":"additional","affiliation":[{"name":"Reproductive Biology Unit, Angers University Hospital, 49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"key":"ref_1","first-page":"68","article-title":"Quality of life in women with endometriosis: A narrative overview","volume":"111","author":"Barra","year":"2020","journal-title":"Minerva Med."},{"key":"ref_2","first-page":"79","article-title":"Sexuality in women with endometriosis: A critical narrative review","volume":"111","author":"Barra","year":"2020","journal-title":"Minerva Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Santoro, A., Angelico, G., Inzani, F., Spadola, S., Arciuolo, D., Valente, M., Fiorentino, V., Mul\u00e8, A., Scambia, G., and Zannoni, G.F. 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