{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:22:30Z","timestamp":1781493750429,"version":"3.54.1"},"reference-count":86,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Endothelial dysfunction is an early abnormality in the process of atherosclerosis and cardiovascular disease and has been associated with worse clinical outcome. Cardiac rehabilitation (CR) has been reported to be helpful to reduce cardiovascular events in various types of cardiac disease, but the mechanisms of its beneficial effects remain only partially known. In this article, we review the studies that assessed the effect of CR on endothelial function in patients with various cardiac conditions. Available data show that CR significantly improves impaired endothelial function in these patients, which may contribute to the beneficial effects of CR on clinical outcome.<\/jats:p>","DOI":"10.3390\/jcm9082487","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T07:45:57Z","timestamp":1596440757000},"page":"2487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cardiac Rehabilitation and Endothelial Function"],"prefix":"10.3390","volume":"9","author":[{"given":"Gaetano Antonio","family":"Lanza","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Department of Cardiovascular Medicine, Universit\u00e0 Cattolica del S. Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-0127","authenticated-orcid":false,"given":"Michele","family":"Golino","sequence":"additional","affiliation":[{"name":"Department of Heart and Vessels, Ospedale di Circolo, University of Insubria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Villano","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste","family":"Lanza","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine and Psychology, Universit\u00e0 La Sapienza, 00189 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Lamendola","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Fusco","sequence":"additional","affiliation":[{"name":"Fondazione Don Carlo Gnocchi IRCCS, 20147 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Cardiology Operative Unit, San Filippo Neri Hospital, 00135 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2015.10.044","article-title":"Exercise-based rehabilitation for coronary heart disease (Review)","volume":"67","author":"Anderson","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.tcm.2017.02.005","article-title":"The role of cardiac rehabilitation in patients with heart disease","volume":"27","author":"McMahon","year":"2017","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ambrosetti, M., Abreu, A., Corr\u00e0, U., Davos, C.H., Hansen, D., Frederix, I., Iliou, M.C., Pedretti, R.F., Schmid, J.P., and Vigorito, C. (2020). Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Eur. J. Prev. Cardiol, (in press).","DOI":"10.1177\/2047487320913379"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1177\/2047487319839819","article-title":"Cardiac rehabilitation in the elderly patient in eight rehabilitation units in Western Europe: Baseline data from the EU-CaRE multicentre observational study","volume":"26","author":"Prescott","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijcard.2016.12.125","article-title":"Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis","volume":"232","author":"Deckers","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ahj.2011.07.017","article-title":"Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: A systematic review and meta-analysis of randomized controlled trials","volume":"162","author":"Lawler","year":"2011","journal-title":"Am. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S349","DOI":"10.1016\/j.cjca.2016.07.507","article-title":"Comprehensive cardiovascular risk reduction and cardiac rehabilitation in diabetes and the metabolic syndrome","volume":"32","author":"Heinl","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1177\/2047487318781359","article-title":"Determinants of participation and risk factor control according to attendance in cardiac rehabilitation programmes in coronary patients in Europe: EUROSPIRE IV survey","volume":"25","author":"Kotseva","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S365","DOI":"10.1016\/j.cjca.2016.07.508","article-title":"Impact of cardiac rehabilitation and exercise training on psychological risk factors and subsequent prognosis in patients with cardiovascular disease","volume":"31","author":"Lavie","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.CIR.0000151788.08740.5C","article-title":"Cardiac rehabilitation and secondary prevention of coronary heart disease: An American Heart Association Scientific Statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in Collaboration With the American Association of Cardiovascular and Pulmonary Rehabilitation","volume":"111","author":"Leon","year":"2005","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1161\/CIR.0b013e31823b21e2","article-title":"Referral, enrollment and delivery of cardiac rehabilitation\/secondary prevention programs at clinical centers and beyond: A presidential advisory from the American Heart Association","volume":"124","author":"Balady","year":"2011","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"ESC guidelines for the management of acute myocardial infarction in patients presenting with ST segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"ESC Guidelines for diagnosis and treatment of acute and chronic heart failure","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"European Guidelines on cardiovascular disease prevention in clinical practice","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1161\/ATVBAHA.117.309813","article-title":"Endothelial functions","volume":"37","author":"Godo","year":"2017","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: Testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/5584_2016_90","article-title":"Endothelial dysfunction and hypertension","volume":"956","author":"Konukoglu","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/1753-0407.12521","article-title":"Macro and microvascular endothelial dysfunction in diabetes","volume":"9","author":"Shi","year":"2017","journal-title":"J. Diabetes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.113.300156","article-title":"Smoking and cardiovascular disease: Mechanisms of endothelial dysfunction and early atherogenesis","volume":"34","author":"Messner","year":"2014","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1055\/s-2000-13209","article-title":"Endothelial dysfunction in hypercholesterolemia: Mechanisms, pathophysiological importance, and therapeutic interventions","volume":"26","author":"Landmesser","year":"2000","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijcard.2008.01.021","article-title":"Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease","volume":"134","author":"Shechter","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijcard.2012.09.047","article-title":"Flow-mediated dilation and cardiovascular risk prediction: A systematic review with meta-analysis","volume":"168","author":"Ras","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e002270","DOI":"10.1161\/JAHA.115.002270","article-title":"Prognostic value of flow-mediated vasodilation in brachial artery and fingertip artery for cardiovascular events: A systematic review and metaanalysis","volume":"4","author":"Matsuzawa","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.CIR.0000012543.55874.47","article-title":"Risk stratification for postoperative cardiovascular events via non invasive assessment of endothelial function: A prospective study","volume":"105","author":"Gokce","year":"2002","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","article-title":"Prognostic impact of coronary vasodilator dysfunction and adverse long-term outcome of coronary heart disease","volume":"101","author":"Britten","year":"2000","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/01.CIR.0000025404.78001.D8","article-title":"Prognostic value of coronary vascular endothelial function","volume":"106","author":"Halcox","year":"2002","journal-title":"Circulation"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1161\/hc4601.099485","article-title":"Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease","volume":"104","author":"Heitzer","year":"2001","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0002-9149(00)00857-2","article-title":"Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain","volume":"86","author":"Neunteufl","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Silva, I.V.G., de Figueiredo, R.C., and Rios, D.R.A. (2019). Effect of Different Classes of Antihypertensive Drugs on Endothelial Function and Inflammation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143458"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM199502233320802","article-title":"The effect of cholesterol-lowering and antioxidant therapy on endothelium dependent coronary vasomotion","volume":"332","author":"Anderson","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2004.068197","article-title":"Effect of exercise training on endothelium-derived nitric oxide function in humans","volume":"561","author":"Green","year":"2004","journal-title":"J. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.pcad.2014.12.005","article-title":"Exercise interventions and peripheral arterial function: Implications for cardiac metabolic disease","volume":"57","author":"Phillips","year":"2015","journal-title":"Progr. Cardiovasc. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S1734-1140(10)70305-4","article-title":"Endurance training increases exercise-induced prostacyclin release in young, healthy men-relationship with VO2max","volume":"62","author":"Zoladz","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00014.2016","article-title":"Vascular adaptation to exercise in humans: Role of hemodynamic stimuli","volume":"97","author":"Green","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.jacc.2004.08.062","article-title":"Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia","volume":"44","author":"Bonetti","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0002-9149(98)00702-4","article-title":"Endothelium-dependent flow mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease","volume":"82","author":"Takase","year":"1998","journal-title":"Am. J. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The Assessment of Endothelial Function. From Research Into Clinical Practice","volume":"126","author":"Flammer","year":"2012","journal-title":"Circulation"},{"key":"ref_39","first-page":"262","article-title":"Methods of endothelial function assessment: Description and applicaions","volume":"30","author":"Storch","year":"2017","journal-title":"Int. J. Card. Sci."},{"key":"ref_40","first-page":"291","article-title":"Endothelial dysfunction and cardiovascular disease","volume":"3","author":"Widmer","year":"2014","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.atherosclerosis.2015.05.007","article-title":"The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society","volume":"241","author":"Vlachopoulos","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/HJH.0b013e328353f222","article-title":"Assessment of flow-mediated dilation reproducibility: A nationwide multicenter study","volume":"30","author":"Ghiadoni","year":"2012","journal-title":"J. Hyperten."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.numecd.2010.10.004","article-title":"Effect of bariatric surgery on peripheral flow-mediated dilation and coronary microvascular function","volume":"22","author":"Nerla","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1093\/eurheartj\/eht351","article-title":"Endothelial dysfunction over the course of coronary artery disease","volume":"34","author":"Flammer","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.pcad.2014.11.005","article-title":"Assessment and prognosis of peripheral artery measures of vascular function","volume":"57","author":"Anderson","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCULATIONAHA.109.864801","article-title":"Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: The multi-ethnic study of atherosclerosis","volume":"120","author":"Yeboah","year":"2009","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e3215","DOI":"10.1002\/dmrr.3215","article-title":"Endothelial dysfunction and cardiovascular outcome in asymptomatic patients with type 2 diabetes: A pilot study","volume":"36","author":"Villano","year":"2020","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_48","first-page":"904141","article-title":"Evaluation of the EndoPAT as a tool to assess endothelial function","volume":"2012","author":"Moerland","year":"2012","journal-title":"Int. J. Vasc. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/japplphysiol.01285.2005","article-title":"Role of nitric oxide in the regulation of digital pulse volume amplitude in humans","volume":"101","author":"Nohria","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1161\/CIRCULATIONAHA.107.748574","article-title":"Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study","volume":"117","author":"Hamburg","year":"2008","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/1358863X06076227","article-title":"Assessment of peripheral vascular endothelial function in the ambulatory setting","volume":"12","author":"Kuvin","year":"2007","journal-title":"Vasc. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/eurheartj\/ehq010","article-title":"Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events","volume":"31","author":"Rubinshtein","year":"2010","journal-title":"Eur. Heart. J."},{"key":"ref_53","first-page":"2969740","article-title":"A comparison of measures of endothelial function in patients with peripheral arterial disease and age and gender matched controls","volume":"2016","author":"Allan","year":"2016","journal-title":"Int. J. Cardiovasc. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/MCA.0000000000000094","article-title":"Comparison of peripheral arterial tonometry and flow-mediated vasodilation for assessment of the severity and complexity of coronary artery disease","volume":"25","author":"Woo","year":"2014","journal-title":"Coron. Artery Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/1358863X17706752","article-title":"Reliability of peripheral arterial tonometry in patients with heart failure, diabetic nephropathy and arterial hypertension","volume":"22","author":"Weisrock","year":"2017","journal-title":"Vasc. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/eci.12341","article-title":"Reproducibility of peripheral arterial tonometry measurements in male cardiovascular patients","volume":"44","author":"Nil","year":"2014","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1253\/circj.CJ-11-1050","article-title":"Evaluation of circulating endothelial progenitor cells in cardiovascular risk","volume":"75","author":"Fujita","year":"2011","journal-title":"Circ. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-1759(01)00408-2","article-title":"Endothelial cell culture: Protocol to obtain and cultivate human umbilical endothelial cells","volume":"254","author":"Marin","year":"2001","journal-title":"J. Immunol. Methods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0735-1097(96)00472-X","article-title":"Nitric oxide activity in the atherosclerotic human coronary circulation","volume":"29","author":"Quyyumi","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0733-8651(05)70321-0","article-title":"Clinical application of coronary flow reserve using an intracoronary Doppler guide wire","volume":"15","author":"Joye","year":"1997","journal-title":"Cardiol. Clin."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e005361","DOI":"10.1161\/CIRCINTERVENTIONS.117.005361","article-title":"Invasive assessment of the coronary microvasculature. The index of microcirculatory resistance","volume":"10","author":"Fearon","year":"2017","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0002-9149(99)80132-5","article-title":"Comparison of the effects of exercise and cold pressure test on the vasomotor response of normal and atherosclerotic coronary arteries and their relation to the flow-mediated mechanism","volume":"76","author":"Dupouy","year":"1995","journal-title":"Am. J. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1161\/01.CIR.62.5.925","article-title":"Provocation of coronary artery spasm by the cold pressor test. Hemodynamic, arteriographic and quantitative angiographic observations","volume":"62","author":"Raizner","year":"1980","journal-title":"Circulation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/eci.12389","article-title":"Noninvasive study of coronary microcirculation response to a cold pressure test","volume":"45","author":"Pham","year":"2015","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/heartjnl-2017-312832","article-title":"Cardiac rehabilitation and physical activity: Systematic review and meta-analysis","volume":"104","author":"Dibben","year":"2018","journal-title":"Heart"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1177\/2047487316671181","article-title":"The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: A systematic review and meta-analysis of randomized and non-randomized studies\u2014The Cardiac Rehabilitation Outcome Study (CROS)","volume":"23","author":"Rauch","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Salzwedel, A., Jensen, K., Rauch, B., Doherty, P., Metzendorf, M.I., Hackbusch, M., V\u00f6ller, H., Schmid, J.P., and Davos, C.H. (2020). Effectiveness of comprehensive cardiac rehabilitation in coronary artery disease patients treated according to contemporary evidence based medicine: Update of the Cardiac Rehabilitation Outcome Study (CROS-II). Eur. J. Prev. Cardiol, (in press).","DOI":"10.1177\/2047487320905719"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.ahj.2003.12.023","article-title":"Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction","volume":"147","author":"Vona","year":"2004","journal-title":"Am. Heart J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1136\/hrt.2006.092163","article-title":"BRUM Investigators. Plasma haemostatic markers, endothelial function and ambulatory blood pressure changes with home versus hospital cardiac rehabilitation: The Birmingham Rehabilitation Uptake Maximisation Study","volume":"92","author":"Lee","year":"2006","journal-title":"Heart"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5603\/KP.a2015.0177","article-title":"The impact of physical training on endothelial function in myocardial infarction survivors: Pilot study","volume":"74","author":"Peller","year":"2016","journal-title":"Kardiol. Pol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.atherosclerosis.2014.12.057","article-title":"Effect of exercise-based cardiac rehabilitation on arterial stiffness and inflammatory and endothelial dysfunction biomarkers: A randomized controlled trial of myocardial infarction patients","volume":"239","author":"Oliveira","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/2047487312460516","article-title":"Exercise-based cardiac rehabilitation improves endothelial function assessed by flow-mediated dilation but not by pulse amplitude tonometry","volume":"21","author":"Cornelissen","year":"2014","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.amjcard.2003.11.032","article-title":"Effect of Exercise Training on Endothelial Function in Men with Coronary Artery Disease","volume":"93","author":"Edwards","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0002-9149(02)02433-5","article-title":"Effect of Exercise on Upper and Lower Extremity Endothelial Function in Patients with Coronary Artery Disease","volume":"90","author":"Gokce","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.thromres.2015.11.012","article-title":"Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise","volume":"137","author":"Gagliardi","year":"2016","journal-title":"Thromb. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijcard.2014.10.155","article-title":"Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: The SAINTEX-CAD study","volume":"179","author":"Conraads","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"H1876","DOI":"10.1152\/ajpheart.00341.2015","article-title":"Effects of aerobic interval training and continuous training on cellular markers of endothelial integrity in coronary artery disease: A SAINTEX-CAD substudy","volume":"309","author":"Frederix","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJM200002173420702","article-title":"Effect of exercise on coronary endothelial function in patients with coronary artery disease","volume":"342","author":"Hambrecht","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s00380-018-1128-2","article-title":"Heart failure with preserved vs reduced ejection fraction following cardiac rehabilitation: Impact of endothelial function","volume":"33","author":"Tanaka","year":"2018","journal-title":"Heart Vessel."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/2047487314565739","article-title":"Cardiac rehabilitation improves coronary endothelial function in patients with heart failure due to dilated cardiomyopathy: A positron emission tomography study","volume":"23","author":"Legallois","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/01.CIR.88.1.55","article-title":"Impaired acetylcholine mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors","volume":"88","author":"Katz","year":"1993","journal-title":"Circulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1161\/01.CIR.84.4.1589","article-title":"Endothelium-dependent vasodilation is attenuated in patients with heart failure","volume":"84","author":"Kubo","year":"1991","journal-title":"Circulation"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/01.CIR.0000153349.77489.CF","article-title":"Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure","volume":"111","author":"Katz","year":"2005","journal-title":"Circulation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jacc.2005.04.060","article-title":"Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: Comparison with B-type natriuretic peptide","volume":"46","author":"Meyer","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1177\/2047487319854140","article-title":"German Society of Cardiovascular Prevention and Rehabilitation (DGPR). Exercise-based cardiac rehabilitation in patients with reduced left ventricular ejection fraction: The Cardiac Rehabilitation Outcome Study in Heart Failure (CROS-HF): A systematic review and meta-analysis","volume":"27","author":"Nebel","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.mayocp.2017.07.019","article-title":"Effect of cardiac rehabilitation dose on mortality and morbidity: A Systematic Review and Meta-regression Analysis","volume":"92","author":"Marzolini","year":"2017","journal-title":"Mayo Clin. 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