{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:59:17Z","timestamp":1776941957931,"version":"3.51.4"},"reference-count":71,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Little is known about the impact of pathophysiological mechanisms that underlie the enhancement of excitotoxicity and the neuronal consequences of status epilepticus (SE), as well as the clinical consequences of secondary brain insults (SBI) in patients with SE on outcome; (2) Methods: Electronic searches were conducted in May 2020 using Medline via PubMed, Embase, and Google Scholar (#CRD42019139092). Experimental studies of animals or randomized, observational, controlled trials of patients with SE in indexed journals were included. There were no language or date restrictions for the published literature included in this review. Information was extracted on study design, sample size, SBI characteristics, and primary and secondary outcomes, including the timing of evaluation; (3) Results: Among the 2209 articles responding to our inclusion criteria, 56 were included in this systematic review. There are numerous experimental data reporting the deleterious effects associated with each of the SBI in animals exposed to SE. In humans, only the effect of target temperature management in hypothermia (32\u201334 \u00b0C) has been explored. (4) Conclusions: There is little experimental evidence that favors the control of secondary brain insult after SE. Further studies are required to assess the neuroprotective interest of secondary brain insult control after SE in humans.<\/jats:p>","DOI":"10.3390\/jcm9082521","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T06:02:21Z","timestamp":1596607341000},"page":"2521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Secondary Brain Insults in Status Epilepticus: A Systematic Review"],"prefix":"10.3390","volume":"9","author":[{"given":"Candice","family":"Fontaine","sequence":"first","affiliation":[{"name":"Medical-Surgical Intensive Care Unit, Hopital Paris Saint Joseph, 185 Rue Raymond Losserand, 75014 Paris, France"},{"name":"IctalGroup, 177 rue de Versailles, 78150 Le Chesnay CEDEX, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwenaelle","family":"Jacq","sequence":"additional","affiliation":[{"name":"IctalGroup, 177 rue de Versailles, 78150 Le Chesnay CEDEX, France"},{"name":"Intensive Care Department, Centre Hospitalier de Versailles, 177 rue de Versailles, 78150 Le Chesnay CEDEX, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Perier","sequence":"additional","affiliation":[{"name":"IctalGroup, 177 rue de Versailles, 78150 Le Chesnay CEDEX, France"},{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, CHU Henri Mondor, 51 Avenue du Mar\u00e9chal de Lattre de Tassigny, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Holleville","sequence":"additional","affiliation":[{"name":"IctalGroup, 177 rue de Versailles, 78150 Le Chesnay CEDEX, France"},{"name":"Department of Anaesthesiology and Critical Care, H\u00f4pitaux Universitaires Paris Nord Val de Seine, H\u00f4pital Beaujon, 100 Boulevard du G\u00e9n\u00e9ral Leclerc, 92110 Clichy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Legriel","sequence":"additional","affiliation":[{"name":"IctalGroup, 177 rue de Versailles, 78150 Le Chesnay CEDEX, France"},{"name":"Intensive Care Department, Centre Hospitalier de Versailles, 177 rue de Versailles, 78150 Le Chesnay CEDEX, France"},{"name":"UVSQ, INSERM, University Paris-Saclay, CESP, Team \u00abPsyDev\u00bb, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Holleville, M., Jacq, G., Perier, F., Fontaine, C., and Legriel, S. 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