{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:09:28Z","timestamp":1760238568968,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We investigated whether the bone-synthetic activities of vertebral bodies or vertebral corners quantified using 18F-fluoride positron emission tomography (PET) was associated with bone mineral density (BMD) at the corresponding lumbar vertebrae in ankylosing spondylitis (AS) at each vertebra level. We analyzed 48 lumbar vertebrae in 12 AS patients who underwent 18F-fluoride PET and dual energy X-ray absorptiometry (DXA). The mean standardized uptake values (SUVmean) of the vertebral body and corners from L1 to L4 were measured using the spatially separated region of interest (ROI). The L1\u2013L4 BMDs were calculated based on the DXA (\u201cconventional BMD\u201d). The BMD of the internal vertebral bodies was measured by manually drawing ROIs to represent the trabecular BMD (\u201calternative BMD\u201d). After adjusting the within-patient correlation, the 18F-fluoride SUVmean of the vertebral corners but not that of vertebral bodies was significantly related with the conventional BMD of the vertebra. Otherwise, the 18F-fluoride uptake of both the vertebral and vertebral bodies was significantly related with the alternative BMD. The bone-synthetic activities of the vertebral corners may be more closely related with BMD than those of the vertebral bodies, suggesting that the effects of regional bone metabolism at the vertebral corners and bodies on BMD differ in AS.<\/jats:p>","DOI":"10.3390\/jcm9082656","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T06:33:20Z","timestamp":1597646000000},"page":"2656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Regional Bone Synthetic Activities of Vertebral Corners and Vertebral Bodies Quantified Using 18F-Fluoride Positron Emission Tomography with Bone Mineral Density on Dual Energy X-ray Absorptiometry in Patients with Ankylosing Spondylitis"],"prefix":"10.3390","volume":"9","author":[{"given":"Keunyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Pusan National University Hospital, Busan 49241, Korea"},{"name":"Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoungjune","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Pusan National University Hospital, Busan 49241, Korea"},{"name":"Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Pusan National University Hospital, Busan 49241, Korea"},{"name":"Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Jang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-0611","authenticated-orcid":false,"given":"Dong Hyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 50612, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aran","family":"Kim","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"},{"name":"Divsion of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-3978","authenticated-orcid":false,"given":"Seung-Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea"},{"name":"Divsion of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan 49241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.berh.2010.01.005","article-title":"Can we stop progression of ankylosing spondylitis?","volume":"24","author":"Schett","year":"2010","journal-title":"Best Pract. 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