{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:53:40Z","timestamp":1784555620476,"version":"3.55.0"},"reference-count":95,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Retinopathy of prematurity (ROP) is a leading cause of potentially preventable blindness in low birth weight preterm infants. Several perinatal and postnatal factors contribute to the incomplete maturation of retinal vascularization, leading to oxidative stress damage. Literature data suggest that the lack of equilibrium between pro-oxidants and anti-oxidants plays a key role. In the last decade, there has been an increasing interest in identifying the antecedents of ROP and the relevant pathogenic mechanisms involved. In this context, a panel of biomarkers was investigated in order to achieve early detection of oxidative stress occurrence and to prevent retinal damage. Several nutritional elements have been found to play a relevant role in ROP prevention. At this stage, no conclusive data have been shown to support the usefulness of one biomarker over another. Recently, the Food and Drugs Administration, the European Medicine Agency, and the National Institute of Health proposed a series of criteria in order to promote the inclusion of new biomarkers in perinatal clinical guidelines and daily practice. The aim of the present review is to offer an update on a panel of biomarkers, currently investigated as potential predictors of ROP, highlighting their strengths and weaknesses.<\/jats:p>","DOI":"10.3390\/jcm9092711","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T21:28:06Z","timestamp":1598218086000},"page":"2711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Oxidative Stress Markers and the Retinopathy of Prematurity"],"prefix":"10.3390","volume":"9","author":[{"given":"Alessandro","family":"Graziosi","sequence":"first","affiliation":[{"name":"Neonatal Intensive Unit Care, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"},{"name":"Department of Paediatrics, University \u201cG. d\u2019 Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Unit Care, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"},{"name":"Department of Paediatrics, University \u201cG. d\u2019 Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Russo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Unit Care, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"},{"name":"Department of Paediatrics, University \u201cG. d\u2019 Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Gasparroni","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Unit Care, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"},{"name":"Department of Paediatrics, University \u201cG. d\u2019 Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"D\u2019Egidio","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Unit Care, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Italian Academy of Traditional Osteopathy (AIOT), 65100 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Di Marzio","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University \u201cG. 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Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5455\/medarh.2015.69.409-413","article-title":"Risk factors for retinopathy of prematurity in premature born children","volume":"69","author":"Zvizdic","year":"2015","journal-title":"Med. Arch."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e20183061","DOI":"10.1542\/peds.2018-3061","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"142","author":"Fierson","year":"2018","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.siny.2015.06.004","article-title":"Retinopathy of prematurity and neurodevelopmental disabilities in premature infants","volume":"20","author":"Beligere","year":"2015","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.earlhumdev.2007.11.009","article-title":"Retinopathy of prematurity: A global perspective of the epidemics, population of babies at risk and implications for control","volume":"84","author":"Gilbert","year":"2008","journal-title":"Early Hum. Dev."},{"key":"ref_6","first-page":"56","article-title":"Management of retinopathy of prematurity-use of anti-VEGF therapy","volume":"7","author":"Tran","year":"2018","journal-title":"Asia-Pacific J. Ophthalmol."},{"key":"ref_7","first-page":"124","article-title":"Retinopathy of prematurity","volume":"78","author":"Bashinsky","year":"2017","journal-title":"N. C. Med. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","article-title":"Retinopathy of prematurity","volume":"382","author":"Smith","year":"2013","journal-title":"Lancet"},{"key":"ref_9","first-page":"189","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"13","author":"Fierson","year":"2013","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3928\/23258160-20170630-06","article-title":"The epidemiology of retinopathy of prematurity in the United States","volume":"48","author":"Ludwig","year":"2017","journal-title":"Ophthalmic Surg. Lasers Imaging Retin."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1824-7288-39-43","article-title":"Survey on retinopathy of prematurity (ROP) in Italy","volume":"39","author":"Borroni","year":"2013","journal-title":"Ital. J Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ophtha.2014.07.050","article-title":"Pathophysiology and mechanisms of severe retinopathy of prematurity","volume":"122","author":"Hartnett","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/09286586.2019.1606259","article-title":"Perinatal risk factors for the retinopathy of prematurity in postnatal growth and rop study","volume":"26","author":"Ying","year":"2019","journal-title":"Ophthalmic. Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000330174","article-title":"Understanding retinopathy of prematurity: Update on pathogenesis","volume":"100","author":"Rivera","year":"2011","journal-title":"Neonatology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10456-007-9066-0","article-title":"Retinopathy of prematurity","volume":"10","author":"Chen","year":"2007","journal-title":"Angiogenesis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.biocel.2009.10.006","article-title":"Proliferative retinopathies: Angiogenesis that blinds","volume":"42","author":"Sapieha","year":"2010","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and Management of Retinopathy of Prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N. Engl. J Med."},{"key":"ref_18","first-page":"458","article-title":"Pro-oxidants and antioxidants in retinopathy of prematurity","volume":"57","author":"Banjac","year":"2018","journal-title":"Acta Clin. Croat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2741\/4382","article-title":"Retinopathy of prematurity: An oxidative stress neonatal disease","volume":"21","author":"Stone","year":"2016","journal-title":"Front. Biosci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Rivera, J.C., Dabouz, R., Noueihed, B., Omri, S., and Tahiri Chemtob, S. (2017). Ischemic retinopathies: Oxidative stress and inflammation. Oxid. Med. Cell. Longev., 3940241.","DOI":"10.1155\/2017\/3940241"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1203\/00006450-200207000-00010","article-title":"Oxidative stress in preterm neonates at birth and on the seventh day of life","volume":"52","author":"Buonocore","year":"2002","journal-title":"Pediatr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1073\/pnas.101113998","article-title":"Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity","volume":"98","author":"Hellstrom","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/jamaophthalmol.2013.986","article-title":"Signaling Pathways Triggered by Oxidative Stress That Mediate Features of Severe Retinopathy of Prematurity","volume":"131","author":"Wang","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0002-9440(10)63001-5","article-title":"Inhibition of NAD(P)H Oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy","volume":"167","author":"Shabrawey","year":"2005","journal-title":"Am. J. Path."},{"key":"ref_25","first-page":"222","article-title":"Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice","volume":"42","author":"Brooks","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.freeradbiomed.2004.09.008","article-title":"Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy","volume":"37","author":"Beauchamp","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1152\/ajpcell.00424.2002","article-title":"Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite","volume":"285","author":"Gu","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_28","first-page":"939","article-title":"Hypercapnia and Trans-Arachidonic acid-induced retinal microvascular degeneration: Implications in the genesis of retinopathy of prematurity","volume":"23","author":"Leduc","year":"2007","journal-title":"Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0891-5849(98)00095-1","article-title":"Oxidative chemistry of nitric oxide: The roles of superoxide, peroxynitrite, and carbon dioxide","volume":"25","author":"Squadrito","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","first-page":"1341","article-title":"Mechanisms and biological consequences of nitrosative stress","volume":"384","author":"Kroncke","year":"2003","journal-title":"Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1021\/tx980096z","article-title":"Peroxynitrite reactions and diffusion in biology","volume":"11","author":"Radi","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.freeradbiomed.2005.09.016","article-title":"Hypercapnia prevents neovascularization via nitrative stress","volume":"40","author":"Checchin","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0945-053X(03)00005-2","article-title":"Thrombospondins 1 and 2 function as inhibitors of angiogenesis","volume":"22","author":"Armstrong","year":"2003","journal-title":"Matrix. Biol."},{"key":"ref_34","first-page":"1735","article-title":"Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells","volume":"57","author":"Guo","year":"1997","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000025733","article-title":"Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway","volume":"37","author":"Nor","year":"2000","journal-title":"J. Vasc. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.resp.2019.05.006","article-title":"Intermittent hypoxemia and oxidative stress in preterm infants","volume":"266","author":"Vento","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/cclm-2019-0725","article-title":"Early predictors of perinatal brain damage: The role of neurobiomarkers","volume":"58","author":"Bersani","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s12291-011-0180-9","article-title":"Free radical status in retinopathy of prematurity","volume":"27","author":"Garg","year":"2012","journal-title":"Indian J. Clin. Bio Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.numecd.2005.05.003","article-title":"A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress","volume":"15","author":"Stewart","year":"2005","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/112067210901900112","article-title":"Oxidative DNA damage in retinopathy of prematurity","volume":"19","author":"Ates","year":"2009","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/15287399309531806","article-title":"8- Hydroxydeoxyguanosine as a urine biormarker of oxidative DNA damage","volume":"40","author":"Loft","year":"1993","journal-title":"J. Toxicol. Environ. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/carcin\/11.9.1447","article-title":"The role of 8- hydroxyguanine in carcinogenesis","volume":"11","author":"Floyd","year":"1990","journal-title":"Carcionogenesis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/112067210801800116","article-title":"Urine 8-deoxyguanosine levels in diabetic retinopathy patients","volume":"18","author":"Dong","year":"2008","journal-title":"Eur. J. Ophtalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.freeradbiomed.2004.09.017","article-title":"Biomarkers of oxidative stress study II: Are oxidation products of lipids, proteins, and DNA markers of CC14 poisoning?","volume":"15","author":"Kadiiska","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"ref_45","first-page":"413","article-title":"The estimation of selected parameters in antioxidant system in red blood cells in ROP screening of premature infants","volume":"108","author":"Dzienis","year":"2006","journal-title":"Klin. Oczna."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/nm1095-1024","article-title":"Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity","volume":"1","author":"Alon","year":"1995","journal-title":"Nat. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gupta, P., Narag, M., Banerjee, B.D., and Basu, S. (2004). Oxidative stress in term small for gestational age neonates born to undernourished mothers: A case control study. BMC Pediatr., 4.","DOI":"10.1186\/1471-2431-4-14"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1042\/CS20160068","article-title":"A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy","volume":"130","author":"Deliyanti","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.3390\/molecules15107266","article-title":"The Nrf2 system as a potential target for the development of indirect antioxidants","volume":"15","author":"Jung","year":"2010","journal-title":"Molecules"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/toxsci\/kfr183","article-title":"Beneficial role of Nrf2 in regulating NADPH generation and consumption","volume":"123","author":"Wu","year":"2011","journal-title":"Toxicol. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00125-013-3093-8","article-title":"NRF2 plays a protective role in diabetic retinopathy in mice","volume":"57","author":"Xu","year":"2014","journal-title":"Diabetologia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1167\/iovs.13-11598","article-title":"Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy","volume":"54","author":"Zhong","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.exer.2009.12.012","article-title":"Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy","volume":"90","author":"Uno","year":"2010","journal-title":"Exp. Eye. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1124\/pr.111.004846","article-title":"Synthetic oleanane triterpenoids: Multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease","volume":"64","author":"Liby","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1073\/pnas.0500815102","article-title":"Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress","volume":"102","author":"Liby","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/02713683.2019.1645184","article-title":"Stanniocalcin-1 is a modifier of oxygen induced retinopathy severity","volume":"45","author":"Dalvin","year":"2020","journal-title":"Curr. Eye Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.2353\/ajpath.2009.080476","article-title":"Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis","volume":"174","author":"Huang","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.bbrc.2014.09.060","article-title":"Stanniocalcin-1 is induced by hypoxia inducible factor in rat alveolar epithelial cells","volume":"452","author":"Ito","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/FJC.0000000000000146","article-title":"Recombinant adeno-associated virus-delivered hypoxia-inducible stanniocalcin-1 expression effectively inhibits hypoxia-induced cell apoptosis in cardiomyocytes","volume":"64","author":"Shi","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuroscience.2012.10.062","article-title":"Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance","volume":"229","author":"Westberg","year":"2013","journal-title":"Neuroscience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1073\/pnas.97.7.3637","article-title":"Stanniocalcin: A molecular guard of neurons during cerebral ischemia","volume":"97","author":"Zhang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/mt.2011.308","article-title":"Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration","volume":"20","author":"Roddy","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kim, S.J., Ko, J.H., Yun, J.H., Kim, J.A., Kim, T.E., Lee, H.J., Kim, S.H., Park, K.H., and Oh, J.Y. (2013). Stanniocalcin-1 protects retinalganglion cells by inhibiting apoptosis and oxidative damage. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063749"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1167\/iovs.16-21004","article-title":"Stanniocalcin-1 is an ocular hypotensive agent and a downstream effector molecule that is necessary for the intraocular pressure-lowering effects of latanoprost","volume":"58","author":"Roddy","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mce.2009.07.007","article-title":"Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene","volume":"314","author":"Law","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Tsang, J.K.W., Liu, J., and Lo, A.C.Y. (2019). Vascular and neuronal protection in the developing retina: Potential therapeutic targets for retinopathy of prematurity. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174321"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Pehlivan, F.E. (2017). Vitamin C: An Antioxidant Agent, Vitamin C, IntechOpen.","DOI":"10.5772\/intechopen.69660"},{"key":"ref_68","first-page":"233","article-title":"An overview of ascorbic acid biochemistry","volume":"38","year":"2009","journal-title":"J. Fac. Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-4165(01)00235-5","article-title":"Ascorbic acid: Much more than just an antioxidant","volume":"1569","author":"Arrigoni","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.arplant.59.032607.092811","article-title":"The role of glutathione in photosynthetic organisms: Emerging functions for glutaredoxins and glutathionylation","volume":"59","author":"Rouhier","year":"2008","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1542\/peds.2012-0517","article-title":"Meta-analysis of LCPUFA supplementation of infant for- mula and visual acuity","volume":"131","author":"Qawasmi","year":"2013","journal-title":"Pediatrics"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3945\/ajcn.114.099291","article-title":"Dietary v-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose\u2013endoplasmic reticulum stress reduction to increase adiponectin","volume":"101","author":"Fu","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_73","first-page":"3","article-title":"5-Lipoxygenase Metabolite 4-HDHA is a mediator of the antiangiogenic effect of \u03c9-3 Polyunsaturated Fatty Acids","volume":"9","author":"Sapieha","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.bbadis.2016.05.002","article-title":"Adiponectin in retinopathy","volume":"1862","author":"Fu","year":"2016","journal-title":"Biochim. Biophys. Acta."},{"key":"ref_75","first-page":"18","article-title":"The omega-3 and retinopathy of prematurity relationship","volume":"10","author":"Malamas","year":"2017","journal-title":"Int. J. Ophthalmol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1001\/jamaophthalmol.2017.6658","article-title":"Association of retinopathy of prematurity with low levels of arachidonic acid. A secondary analysis of a randomized clinical trial","volume":"136","author":"Najm","year":"2018","journal-title":"JAMA Ophthalmology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/CIRCRESAHA.110.221317","article-title":"Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy","volume":"107","author":"Stahl","year":"2010","journal-title":"Circ. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1167\/iovs.02-0901","article-title":"Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors","volume":"44","author":"Rotstein","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Li, S.Y., Fu, Z.J., and Lo, A.C.Y. (2012). Hypoxia-induced oxidative stress in ischemic retinopathy. Oxi. Med. Cell. Longev.","DOI":"10.1155\/2012\/426769"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/bjo.82.8.907","article-title":"Fruits and vegetables that are sources for lutein and zeaxanthin: The macular pigment in human eyes","volume":"8","author":"Sommerburg","year":"1998","journal-title":"Br. J. Ophthalmol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0002-8223(93)91553-3","article-title":"Carotenoid content of fruits and vegetables: An evaluation of analytic data","volume":"93","author":"Mangels","year":"1993","journal-title":"J Am. Diet. Assoc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.clinbiochem.2012.07.109","article-title":"Arterial cord blood lutein levels in preterm and term healthy newborns are sex and gestational age dependent","volume":"45","author":"Picone","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clinbiochem.2017.11.017","article-title":"Lutein levels in arterial cord blood correlate with neuroprotein activin A in healthy preterm and term newborns: A trophic role for lutein","volume":"52","author":"Picone","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_84","first-page":"25","article-title":"Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: A multicenter randomized controlled trial","volume":"30","author":"Manzoni","year":"2013","journal-title":"Am. J. Perinatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3109\/14767058.2011.629252","article-title":"Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: A randomized controlled study","volume":"25","author":"Dani","year":"2012","journal-title":"J. Matern. Fetal Neonatal. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/14767058.2011.607618","article-title":"A prospective, randomized, double blind study comparing lutein to placebo for reducing occurrence and severity of retinopathy of prematurity","volume":"24","author":"Romagnoli","year":"2011","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.freeradbiomed.2006.06.023","article-title":"Lutein effect on retina and hippocampus of diabetic mice","volume":"6","author":"Muriach","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1017\/S0007114500002324","article-title":"Antioxidative factors in milk","volume":"84","author":"Akesson","year":"2000","journal-title":"Br. J Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/PL00013811","article-title":"Carotenoid supply in breast-fed and formula-fed neonates","volume":"159","author":"Sommerburg","year":"2000","journal-title":"Eur. J. Pediatr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00394-009-0047-5","article-title":"Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein","volume":"49","author":"Bettler","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"VanderVeen, D.K., Martin, C.R., Mehendale, R., Allred, E.N., and Dammann, O. (2013). Early nutrition and weight gain in preterm newborns and the risk of retinopathy of prematurity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064325"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"107855","DOI":"10.1016\/j.exer.2019.107855","article-title":"Metabolomic changes of blood plasma associated with two phases of rat OIR","volume":"190","author":"Lu","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.61.2.12","article-title":"Targeted blood metabolomic study on retinopathy of prematurity","volume":"61","author":"Yang","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/08820530902800322","article-title":"Emerging Treatments for Retinopathy of Prematurity","volume":"24","author":"Mantagos","year":"2009","journal-title":"Semi. Ophthalmol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"59","DOI":"10.17116\/oftalma2016132659-63","article-title":"Melatonin as a new promising agent for the treatment and prevention of retinopathy of prematurity","volume":"132","author":"Katargina","year":"2016","journal-title":"Vestn. 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