{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:14:27Z","timestamp":1781878467118,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The prognostic value of a prolonged QT interval in SARS-Cov2 infection is not well known. Objective: To determine whether the presence of a prolonged QT on admission is an independent factor for mortality in SARS-Cov2 hospitalized patients. Methods: Single-center cohort of 623 consecutive patients with positive polymerase-chain-reaction test (PCR) to SARS Cov2, recruited from 27 February to 7 April 2020. An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval. A prolonged QT interval was defined as a corrected QT (QTc) interval &gt;480 milliseconds. Patients were followed up with until 10 May 2020. Results: Sixty-one patients (9.8%) had prolonged QTc and only 3.2% had a baseline QTc &gt; 500 milliseconds. Patients with prolonged QTc were older, had more comorbidities, and higher levels of immune-inflammatory markers. There were no episodes of ventricular tachycardia or ventricular fibrillation during hospitalization. All-cause death was higher in patients with prolonged QTc (41.0% vs. 8.7%, p &lt; 0.001, multivariable HR 2.68 (1.58\u20134.55), p &lt; 0.001). Conclusions: Almost 10% of patients with COVID-19 infection have a prolonged QTc interval on admission. A prolonged QTc was independently associated with a higher mortality even after adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin. An electrocardiogram should be included on admission to identify high-risk SARS-CoV-2 patients.<\/jats:p>","DOI":"10.3390\/jcm9092712","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T21:28:06Z","timestamp":1598218086000},"page":"2712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prolonged QT Interval in SARS-CoV-2 Infection: Prevalence and Prognosis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-6572","authenticated-orcid":false,"given":"N\u00faria","family":"Farr\u00e9","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Department of Medicine, School of Medicine, Univ Autonoma de Barcelona, 08003 Barcelona, Spain"},{"name":"Heart Diseases Biomedical Research Group (GREC), IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Moj\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Llagostera","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2774-1290","authenticated-orcid":false,"given":"Laia C.","family":"Belarte-Tornero","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Department of Medicine, School of Medicine, Univ Autonoma de Barcelona, 08003 Barcelona, Spain"},{"name":"Heart Diseases Biomedical Research Group (GREC), IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Calvo-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Department of Medicine, School of Medicine, Univ Autonoma de Barcelona, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermengol","family":"Vall\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Department of Medicine, School of Medicine, Univ Autonoma de Barcelona, 08003 Barcelona, Spain"},{"name":"Heart Diseases Biomedical Research Group (GREC), IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Negrete","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Garc\u00eda-Guimaraes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Bartolom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camino","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Garc\u00eda-Duran","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Marrugat","sequence":"additional","affiliation":[{"name":"REGICOR (Registre Giron\u00ed del Cor) Study Group, IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain"},{"name":"CIBER (Centro de Investigaci\u00f3n Biom\u00e9dica en Red) of Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Vaquerizo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Department of Medicine, School of Medicine, Univ Autonoma de Barcelona, 08003 Barcelona, Spain"},{"name":"Heart Diseases Biomedical Research Group (GREC), IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/jce.14479","article-title":"Cardiac and arrhythmic complications in patients with COVID-19","volume":"31","author":"Kochi","year":"2020","journal-title":"J. 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